N-(8-hydroxyquinolin-5-yl)-N'-(4-nitrophenyl) thiourea | 1096018-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(8-hydroxyquinolin-5-yl)-N'-(4-nitrophenyl) thiourea
• CAS: 1096018-11-9
• 化学式: C₁₆H₁₂N₄O₃S
• 分子量: 340.362
• InChiKey: FVPDOZXWQPOJJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.66
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100.32
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  5-amino-8-hydroxyquinoline dihydrochloride 、 异硫代氰基4-硝基苯酯 以 乙醇 为溶剂， 生成 N-(8-hydroxyquinolin-5-yl)-N'-(4-nitrophenyl) thiourea
  参考文献：
  名称：

  A ditopic colorimetric sensor for fluoride ion based on thiourea mercury complex

  摘要：

  A novel ditopic chromogenic receptor. N-5-(8-hydroxy)quinoline-N'-4'-nitro-phenyl thiourea (1). was synthesized. The metal complex 1-Hg2+ showed sensitive and highly selective responses to F- over other anions such as CH3CO2-, H2PO4-, HSO4- and Cl-, 1-Hg2+-F- complex formed, which promoted the intramolecular charge transfer and led to a dramatic spectral change. The color of 1-Hg2+ solution changed from colorless to red upon addition of F-. Thus, a colorimetric assay of F- was developed in acetonitrile by naked-eye detection. F- behaved linearly in the 8.0 x 10(-6) to 2.0 x 10(-5) mot L-1 concentration range with LOD as 1.4 x 10(-6) mol L-1. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2008.02.024