2-p-tolyl-oxazole-4-carbonitrile | 91135-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-p-tolyl-oxazole-4-carbonitrile
• 英文别名: 2-p-Tolyl-oxazolcarbonsaeure-(4)-nitril；2-(4-Methylphenyl)-1,3-oxazole-4-carbonitrile
• CAS: 91135-46-5
• 化学式: C₁₁H₈N₂O
• mdl: MFCD11587886
• 分子量: 184.197
• InChiKey: XYGXYSUCXLXIPF-UHFFFAOYSA-N

物化性质

• 熔点：
  115-116 °C
• 沸点：
  342.6±44.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-p-tolyl-oxazole-4-carbonitrile 在 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 2-p-Tolyl-oxazol-carbonsaeure-(4)-amidoxim
  参考文献：
  名称：

  Sychewa,T.P. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 3600 - 3603

  摘要：

  DOI：
• 作为产物：
  描述：

  2-对甲苯噁唑-4-羧酸乙酯 在 ammonium hydroxide 、 三氯氧磷 作用下， 生成 2-p-tolyl-oxazole-4-carbonitrile
  参考文献：
  名称：

  Sycheva,T.N. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 1051 - 1055

  摘要：

  DOI：

文献信息

• Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
  申请人：FUJIFILM Corporation

  公开号：US11319347B2

  公开（公告）日：2022-05-03

  An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.

  本发明的目的是提供一种细胞膜渗透性极佳的新型环肽化合物、一种生产该化合物的方法、一种用于筛选的组合物以及一种选择与目标物质结合的环肽化合物的方法。根据本发明，提供了一种由式（1）表示的多肽化合物或其盐。式中的符号具有本申请说明书中定义的含义。
• PEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME, COMPOSITION FOR SCREENING USE, AND METHOD FOR SELECTING PEPTIDE COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20200040039A1

  公开（公告）日：2020-02-06

  An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.
• Sycheva,T.N. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 1051 - 1055
  作者：Sycheva,T.N. et al.

  DOI：——

  日期：——
• Sychewa,T.P. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 3600 - 3603
  作者：Sychewa,T.P. et al.

  DOI：——

  日期：——