(S)-1-cyano-N--N'--1,5-diaminopentane | 175660-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-cyano-N--N'--1,5-diaminopentane
• 英文别名: (S)-1-cyano-N¹-(benzyloxycarbonyl)-N⁵-(tert-butyloxycarbonyl)-1,5-diaminopentane；(S)-1-cyano-N1-(benzyloxycarbonyl)-N5-(tert-butyloxycarbonyl)-1,5-diaminopentane；(S)-6-(tert-butoxycarbonyl)amino-2-(carbobenzoxy)aminohexanenitrile；benzyl N-[(1S)-1-cyano-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentyl]carbamate
• CAS: 175660-26-1
• 化学式: C₁₉H₂₇N₃O₄
• 分子量: 361.441
• InChiKey: FDPMJOSMVWBUPF-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-1-cyano-N--N'--1,5-diaminopentane 在 氨 、 氢气 、 镍 作用下， 以 甲醇 为溶剂， 50.0 ℃ 、689.05 kPa 条件下， 反应 72.0h， 以72%的产率得到5-氨基戊基氨基甲酸苄酯
  参考文献：
  名称：

  一种用于快速分离可接近 DNA 的 Ni(Salen)-生物素偶联物

  摘要：

  DOI：

  10.1021/ja0018670
• 作为产物：
  描述：

  Nε-Boc-Nα-Cbz-L-赖氨酸 在 1,1,1,4,4,4-六氟-2,3-丁二酮 、 氨 、 氯甲酸乙酯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 (S)-1-cyano-N--N'--1,5-diaminopentane
  参考文献：
  名称：

  一种用于快速分离可接近 DNA 的 Ni(Salen)-生物素偶联物

  摘要：

  DOI：

  10.1021/ja0018670

文献信息

• Acceptor-Controlled Transfer Dehydration of Amides to Nitriles
  作者：Hiroyuki Okabe、Asuka Naraoka、Takahiro Isogawa、Shunsuke Oishi、Hiroshi Naka

  DOI：10.1021/acs.orglett.9b01657

  日期：2019.6.21

  dehydration of primary amides to nitriles efficiently proceeds under mild, aqueous conditions via the use of dichloroacetonitrile as a water acceptor. A key to the design of this transfer dehydration catalysis is the identification of an efficient water acceptor, dichloroacetonitrile, that preferentially reacts with amides over other polar functional groups with the aid of the Pd catalyst and makes the desired

  通过使用二氯乙腈作为水受体，在温和的水性条件下钯催化的伯酰胺脱水有效地进行为腈。设计该转移脱水催化的关键是确定一种有效的水受体二氯乙腈，该水受体在Pd催化剂的帮助下优先于酰胺而不是其他极性官能团反应，并使所需的反应体系趋于能动，从而驱动脱水。
• Salen-anthraquinone Conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity
  作者：Sylvain Routier、Nicole Cotelle、Jean-Pierre Catteau、Jean-Luc Bernier、Michael J. Waring、Jean-François Riou、Christian Bailly

  DOI：10.1016/0968-0896(96)00082-x

  日期：1996.8

  A series of amidoethylamino-anthraquinone derivatives bearing either one or two salen (bis(salicylidene)ethylenediamine) moieties complexed with Cu-II or Ni-II have been synthesized, and their DNA-binding and cleaving properties examined. The effects of the mono- and di-substituted anthracenedione-salen conjugates on DNA cleavage mediated by topoisomerases I and II have also been determined, as well as their cytotoxicity toward human KB cells. The anthraquinone-salen . Ni-II conjugates bind to CC-rich sequences in DNA, but do not cleave the macromolecule. By contrast, the anthraquinone-salen . Cu-II hybrids do not recognize particular nucleotide sequences but efficiently induce single-strand breaks in DNA after activation. The 5,8-dihydroxy-anthraquinone conjugates are more cytotoxic and more potent toward topoisomerase II than the non-hydroxylated analogues, but they are less cytotoxic than the salen-free anthraquinones. The attachment of a salen . Cu-II complex to the anthra quinone chromophore can confer DNA cleaving properties in vitro, but this is at the expense of cytotoxic activity. Anthraquinone-salen . Cu-II complexes may find useful employ as footprinting probes for investigating ligand-DNA interactions. Copyright (C) 1996 Elsevier Science Ltd
• Synthesis of a Functionalized Salen−Copper Complex and Its Interaction with DNA
  作者：Sylvain Routier、Jean-Luc Bernier、Michael J. Waring、Pierre Colson、Claude Houssier、Christian Bailly

  DOI：10.1021/jo951840c

  日期：1996.1.1

  An original procedure for efficient synthesis of a functionalized salen copper complex is reported. The mode of binding to DNA of the salen . Cu-II complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen . Cu-II complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.
• US7371579B1
  申请人：——

  公开号：US7371579B1

  公开（公告）日：2008-05-13
• [EN] BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS<br/>[FR] COMPOSES DE BLOCAGE DE CANAUX SODIQUES ÉPITHÉLIAUX À SUBSTITUTION BIPHÉNYLE
  申请人：[en]PARION SCIENCES, INC.

  公开号：WO2023146892A1

  公开（公告）日：2023-08-03

  The present invention relates to ENaC inhibitors (e.g., compounds of Formula (I), and pharmaceutically acceptable salts, stereoisomers, tautomers, isotopically labeled derivatives, solvates, hydrates, polymorphs, co-crystals, and prodrugs thereof). Also disclosed are compositions, methods of preparation, combination therapies, kits, uses, and methods. Exemplary uses include promoting hydration of mucosal surfaces and treating diseases and disorders including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, idiopathic pulmonary fibrosis, and pneumonia.