2-(1-(2-(4-((1-(2-hydroxyphenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)hydrazineylidene)ethyl)phenol | 1185757-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1-(2-(4-((1-(2-hydroxyphenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)hydrazineylidene)ethyl)phenol
• CAS: 1185757-28-1
• 化学式: C₂₄H₂₂N₆O₂
• 分子量: 426.478
• InChiKey: DRFUZNUOZUMYLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.46
• 重原子数：
  32.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  107.92
• 氢给体数：
  3.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2-(1-(2-(4-((1-(2-hydroxyphenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)hydrazineylidene)ethyl)phenol 、 zinc(II) acetate dihydrate 在 NaOAc 作用下， 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis, spectral characterization and biological activity of zinc(II) complexes with 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole Schiff bases

  摘要：

  New Zn(II) complexes have been synthesized by the reactions of zinc(II) acetate with Schiff bases derived from 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole and benzaldehyde, 2-hydroxyacetophenone or indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [ZnL(H(2)O)(2)], [ZnL'(OAc)(2)(H(2)O)(2)] (L=dianionic Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1, 2, 4-triazole and 2-hydroxyacetophenone or indoline-2,3-dione; L'=neutral Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1, 2, 4-triazole and benzaldehyde) and they were characterized by FT-IR, (1)H NMR, (13)C NMR and FAB mass. All these Schiff bases and their complexes have also been screened for their antibacterial activities against Bacillus subtilis, Escherichia coli and antifungal activities against Colletotrichum falcatum, Aspergillus niger, Fusarium oxysporium and Carvularia pallescence by petriplates methods.

  DOI：

  10.1016/j.saa.2011.08.019
• 作为产物：
  描述：

  4-氨基-5-苯基-4H-1,2,4-三唑-3-硫醇 在 盐酸 、 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 生成 2-(1-(2-(4-((1-(2-hydroxyphenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)hydrazineylidene)ethyl)phenol
  参考文献：
  名称：

  Synthesis, spectral characterization and biological activity of zinc(II) complexes with 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole Schiff bases

  摘要：

  New Zn(II) complexes have been synthesized by the reactions of zinc(II) acetate with Schiff bases derived from 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole and benzaldehyde, 2-hydroxyacetophenone or indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [ZnL(H(2)O)(2)], [ZnL'(OAc)(2)(H(2)O)(2)] (L=dianionic Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1, 2, 4-triazole and 2-hydroxyacetophenone or indoline-2,3-dione; L'=neutral Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1, 2, 4-triazole and benzaldehyde) and they were characterized by FT-IR, (1)H NMR, (13)C NMR and FAB mass. All these Schiff bases and their complexes have also been screened for their antibacterial activities against Bacillus subtilis, Escherichia coli and antifungal activities against Colletotrichum falcatum, Aspergillus niger, Fusarium oxysporium and Carvularia pallescence by petriplates methods.

  DOI：

  10.1016/j.saa.2011.08.019

文献信息

• Template synthesis, spectroscopic characterization and preliminary insulin-mimetic activity of oxovanadium(IV) complexes with N2O2 diazadioxa macrocycles
  作者：M.L. Sharma、S.K. Sengupta、O.P. Pandey

  DOI：10.1016/j.saa.2012.04.050

  日期：2012.9

  A new series of diazadioxa oxovanadium(IV) macrocyclic complexes of type [VO(mac)]SO(4) have been synthesized via the condensation reaction of a 3-(phenyl/substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole (H(2)L) with salicylaldehyde/2-hydroxyacetophenone and 1,4-dibromobutane in the presence of oxovanadium(IV) sulfate in ethanol. All the newly synthesized compounds were characterized on the basis

  通过3-（苯基/取代苯基）-4-氨基-5-肼基-1的缩合反应合成了一系列新的[VO（mac）] SO（4）型重氮二氧杂钒（IV）大环配合物。硫酸氧钒（IV）在乙醇中存在的情况下，将2,4-三唑（H（2）L）与水杨醛/ 2-羟基苯乙酮和1,4-二溴丁烷一起使用。根据元素分析，电导测量，磁性能，光谱（UV-Vis，IR，EPR）和XRD研究，对所有新合成的化合物进行了表征。使用Debye-Scherrer公式由XRD光谱计算出了配合物的粒径，发现其在31-32 nm范围内。还在30天的时间里，在链脲佐菌素诱导的糖尿病大鼠中研究了两种大环复合物的功效。