(4E)-ethyl 4,6-heptadienyl-diethylphosphonoacetate | 308084-67-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4E)-ethyl 4,6-heptadienyl-diethylphosphonoacetate
• 英文别名: ethyl (6E)-2-diethoxyphosphorylnona-6,8-dienoate
• CAS: 308084-67-5
• 化学式: C₁₅H₂₇O₅P
• 分子量: 318.35
• InChiKey: OHRXHDKQBROMJZ-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  sodium ethanolate 、 (4E)-ethyl 4,6-heptadienyl-diethylphosphonoacetate 以165 mg的产率得到(3aR*,6aS*)-tetrahydro-3a(3H)-diethylphosphono-1H-cyclopentafuran-3-one
  参考文献：
  名称：

  Intramolecular Carbostannation Reaction of Active Methine Compounds with an Unactivated C−C π-Bond Mediated by SnCl₄−Et₃N

  摘要：

  In the presence of SnCl4 and Et3N, intramolecular carbostannation reaction of various active methine compounds having an unactivated alkenyl, alkynyl, or allenyl group proceeds in good yields with complete regioselectivity. The subsequent reaction of the resulting Sn intermediates with-some electrophiles provides functionalized cyclopentane and cyclohexane derivatives.

  DOI：

  10.1021/jo000784z
• 作为产物：
  描述：

  (4E)-hepta-4,6-dien-1-ol 在 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 (4E)-ethyl 4,6-heptadienyl-diethylphosphonoacetate
  参考文献：
  名称：

  Intramolecular Carbostannation Reaction of Active Methine Compounds with an Unactivated C−C π-Bond Mediated by SnCl₄−Et₃N

  摘要：

  In the presence of SnCl4 and Et3N, intramolecular carbostannation reaction of various active methine compounds having an unactivated alkenyl, alkynyl, or allenyl group proceeds in good yields with complete regioselectivity. The subsequent reaction of the resulting Sn intermediates with-some electrophiles provides functionalized cyclopentane and cyclohexane derivatives.

  DOI：

  10.1021/jo000784z

文献信息

• Intramolecular Carbostannation Reaction of Active Methine Compounds with an Unactivated C−C π-Bond Mediated by SnCl₄−Et₃N
  作者：Osamu Kitagawa、Hiroki Fujiwara、Takashi Suzuki、Takeo Taguchi、Motoo Shiro

  DOI：10.1021/jo000784z

  日期：2000.10.1

  In the presence of SnCl4 and Et3N, intramolecular carbostannation reaction of various active methine compounds having an unactivated alkenyl, alkynyl, or allenyl group proceeds in good yields with complete regioselectivity. The subsequent reaction of the resulting Sn intermediates with-some electrophiles provides functionalized cyclopentane and cyclohexane derivatives.