2,3,4,9-tetrahydro-2-(3-chloropropyl)-1H-pyrido<3,4-b>indole | 107890-30-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3,4,9-tetrahydro-2-(3-chloropropyl)-1H-pyrido<3,4-b>indole
• 英文别名: 2-(3-chloropropyl)-2,3,4,9-tetrahydro-1H-beta-carboline；2,3,4,9-tetrahydro-2-(3-chloropropyl)-1H-pyrido[3,4-b]indole；2-(3-chloropropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole
• CAS: 107890-30-2
• 化学式: C₁₄H₁₇ClN₂
• 分子量: 248.755
• InChiKey: KBZBUKUOHVHIJU-UHFFFAOYSA-N

物化性质

• 沸点：
  407.3±45.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,4,9-tetrahydro-2-(3-chloropropyl)-1H-pyrido<3,4-b>indole 生成 2-[3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]propyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
  参考文献：
  名称：

  ABOU-GHARBIA, MAGID A.

  摘要：

  DOI：
• 作为产物：
  描述：

  色胺 在 potassium carbonate 、 溶剂黄146 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 72.0h， 生成 2,3,4,9-tetrahydro-2-(3-chloropropyl)-1H-pyrido<3,4-b>indole
  参考文献：
  名称：

  [EN] CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  [FR] COMPOSÉS DE CARBOLINE POUVANT ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES

  摘要：

  本发明涉及按照式（A）的化合物或其药学上可接受的盐、溶剂化合物、包合物、水合物或多晶形式，以及其用途。

  公开号：

  WO2014207240A1

文献信息

• 2-(substituted piperazinylalkyl).beta.-carbolines useful in treatment of
  申请人：American Home Products Corporation

  公开号：US04663456A1

  公开（公告）日：1987-05-05

  The .beta.-carbolines N-substituted in 2-position with a piperidinyl alkyl group are antipsychotic agents and anxiolytic agents with minimal extrapyramidal side effects, useful in the treatment of psychological disorders such as paranoia and schizophrania as well as general states of anxiety.

  2-位置上被哌啶基烷基取代的.beta.-咔啉是抗精神病药物和抗焦虑药物，具有最小的锥体外系副作用，在治疗偏执症和精神分裂症等心理障碍以及一般的焦虑状态中有用。
• Carboline Compounds Usable in The Treatment of Neurodegenerative Diseases
  申请人：ALZPROTECT

  公开号：US20160152610A1

  公开（公告）日：2016-06-02

  The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.

  本发明涉及一种具有以下化学式（A）的化合物或其药学上可接受的盐、溶剂化合物、包合物、水合物或多晶形式，以及其用途。
• Psychotropic agents: synthesis and antipsychotic activity of substituted .beta.-carbolines
  作者：Magid Abou-Gharbia、Usha R. Patel、John A. Moyer、Eric A. Muth

  DOI：10.1021/jm00389a022

  日期：1987.6

  A series of novel substituted beta-carbolines was synthesized and tested for potential antipsychotic activity. Several compounds displayed moderate antipsychotic activity in vitro and in vivo as determined by relevant receptor binding assays and behavioral tests. The effect of substituents on antipsychotic activity was examined. The beta-carbolines 10 and 19 containing 2-(2-pyridinyl)ethyl and 2-(2-quinolinyl)ethyl side chains were the most potent analogues, blocking discrete trial conditioned avoidance responding in rats with AB50's of 23 and 10 mg/kg, respectively. Both showed moderate activity at the D2 receptor sites, but they lacked oral activity. In contrast, the beta-carboline 13 containing the 4-(4-pyridinyl)butyl side chain exhibited oral activity in the discrete trial conditioned avoidance screen with an AB50 of 31 mg/kg. Most compounds did not antagonize apomorphine-induced stereotyped behavior, which is indicative of low potential for extrapyramidal side effect (EPS) liability.
• CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Alzprotect

  公开号：EP3013824B1

  公开（公告）日：2018-05-16
• US4663456A
  申请人：——

  公开号：US4663456A

  公开（公告）日：1987-05-05