4-amino-2,3-dihydro-1H-pyrrolo<2,3-b>pyridine | 83683-83-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 4-amino-2,3-dihydro-1H-pyrrolo<2,3-b>pyridine
• 英文别名: 2,3-Dihydro-1H-pyrrolo[2,3-B]pyridin-4-amine
• CAS: 83683-83-4
• 化学式: C₇H₉N₃
• mdl: MFCD12912588
• 分子量: 135.169
• InChiKey: AYGUNCLJXAOPHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  304.1±35.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-amino-2,3-dihydro-1H-pyrrolo<2,3-b>pyridine 在 sodium hydroxide 、 sodium methylate 、 对甲苯磺酸 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 、 xylene 为溶剂， 25.0~135.0 ℃ 、3.33 kPa 条件下， 反应 17.67h， 生成 1-(β-D-呋喃核糖基)-1H-吡咯并[2,3-b]吡啶-4-胺
  参考文献：
  名称：

  合成4-氨基-1-β-D-呋喃呋喃核糖基-1H-吡咯并[2,3-b]吡啶（1-去氮杂菊酯）作为潜在的抗肿瘤剂。

  摘要：

  DOI：

  10.1021/jm00352a035
• 作为产物：
  描述：

  7-氮杂吲哚 在 palladium on activated charcoal 氢气 、 硝酸 、 间氯过氧苯甲酸 、 三氟乙酸 、 三氯化磷 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 25.0 ℃ 、379.21 kPa 条件下， 反应 15.0h， 生成 4-amino-2,3-dihydro-1H-pyrrolo<2,3-b>pyridine
  参考文献：
  名称：

  合成4-氨基-1-β-D-呋喃呋喃核糖基-1H-吡咯并[2,3-b]吡啶（1-去氮杂菊酯）作为潜在的抗肿瘤剂。

  摘要：

  DOI：

  10.1021/jm00352a035

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Ibrahim Prabha N.

  公开号：US20100256365A1

  公开（公告）日：2010-10-07

  Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  本文描述了对蛋白激酶活性起作用的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病况的方法。
• HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：US20140303193A9

  公开（公告）日：2014-10-09

  This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

  本发明涉及抑制E1激活酶的化合物，包括含有该化合物的制药组合物，以及使用该化合物的方法。该化合物可用于治疗疾病，特别是细胞增殖障碍，包括癌症、炎症和神经退行性疾病；以及与感染和消瘦相关的炎症。
• HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS
  申请人：eFFECTOR Therapeutics, Inc.

  公开号：US20170145009A1

  公开（公告）日：2017-05-25

  The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. For Formula IA and Formula IB compounds A 1 , A 2 , A 3 , A 4 , W 1 , W 2 , Y, X, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b , R 6 , R 7 , R 8 , R 9 , R 9a , R 9b , R 10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
• DUAL INHIBITORS OF ALK5 AND P38A MAP KINASE
  申请人：INTEGRAL BIOSCIENCES PRIVATE LIMITED

  公开号：US20200171030A1

  公开（公告）日：2020-06-04

  The present disclosure generally relates to the compounds that exhibits protein kinase inhibitory activity. Specifically, the present disclosure provides compounds of formula (I) that exhibits dual inhibitory activity against ALK5 and P38A MAP kinase. The present disclosure also provides process(es) for preparation of such compounds, pharmaceutical compositions containing one or a combination of these compounds, and methods of treatment of conditions associated with excessive activity of any or a combination of transforming growth factor-beta (TGFβ) and p38 mitogen-activated protein kinase (MAPK) utilizing these compounds. An aspect of the present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salt, polymorph, solvate or stereoisomer thereof that exhibit dual inhibitory activity against ALK5 and P38 alpha.
• Synthesis of 4-amino-1-.beta.-D-ribofuranosyl-1H-pyrrolo[2,3-b]pyridine (1-deazatubercidin) as a potential antitumor agent
  作者：Ippolito Antonini、Francesco Claudi、Gloria Cristalli、Palmarisa Franchetti、Mario Grifantini、Sante Martelli

  DOI：10.1021/jm00352a035

  日期：1982.10