Z-Leu-Glu(OtBu)-NH2 | 138848-62-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Leu-Glu(OtBu)-NH2
• CAS: 138848-62-1
• 化学式: C₂₃H₃₅N₃O₆
• 分子量: 449.547
• InChiKey: XUJFEDFSFPDDOK-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  32.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  136.82
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Z-Leu-Glu(OtBu)-NH2 在 palladium on activated charcoal 氢气 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 H-Glu(OtBu)-Leu-Glu(OtBu)-NH2
  参考文献：
  名称：

  Rigid-Rodβ-Barrels as Lipocalin Models: Probing Confined Space by Carotenoid Encapsulation

  摘要：

  Herein, we describe the design, synthesis, structure, and function of synthetic, supramolecular beta-barrel models. Assembly of octi(p-phenylene)s with complementary -Lys-Leu-Lys-NH2 and Glu-Leu-Glu-NH2 side chains yielded water-soluble rigid-rod beta-barrels of precise length and with flexible diameter. A hydrophobic interior was evidenced by guest encapsulation. Host-guest complexes with planarized, monomeric beta-carotene within tetrameric rigid-rod beta-barrels, and disc micellar astaxanthin J-aggregates surrounded by about dodecameric rigid-rod "bicycle tires" were prepared from mixed micelles by dialytic detergent removal. The significance of these findings for future bioorganic chemistry in confined, intratoroidal space is discussed in comparison with pertinent biological examples.

  DOI：

  10.1002/(sici)1521-3765(20000515)6:10<1739::aid-chem1739>3.0.co;2-y
• 作为产物：
  描述：

  N-苄氧羰基-L-亮氨酸 、 (S)-4,5-二氨基-5-氧代戊酸叔丁酯单盐酸盐 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以84%的产率得到Z-Leu-Glu(OtBu)-NH2
  参考文献：
  名称：

  Rigid-Rodβ-Barrels as Lipocalin Models: Probing Confined Space by Carotenoid Encapsulation

  摘要：

  Herein, we describe the design, synthesis, structure, and function of synthetic, supramolecular beta-barrel models. Assembly of octi(p-phenylene)s with complementary -Lys-Leu-Lys-NH2 and Glu-Leu-Glu-NH2 side chains yielded water-soluble rigid-rod beta-barrels of precise length and with flexible diameter. A hydrophobic interior was evidenced by guest encapsulation. Host-guest complexes with planarized, monomeric beta-carotene within tetrameric rigid-rod beta-barrels, and disc micellar astaxanthin J-aggregates surrounded by about dodecameric rigid-rod "bicycle tires" were prepared from mixed micelles by dialytic detergent removal. The significance of these findings for future bioorganic chemistry in confined, intratoroidal space is discussed in comparison with pertinent biological examples.

  DOI：

  10.1002/(sici)1521-3765(20000515)6:10<1739::aid-chem1739>3.0.co;2-y

文献信息

• 2-Amino-4-pyrrolidinothieno[2,3-<i>d</i>]pyrimidine-6-carboxylic Acid as an<i>N</i>-Terminal Surrogate in Amino Acid and Peptide Analogues
  作者：George Varvounis、Paul Cordopatis、Evangelos E. Bissyris、Dimitris Belekos、Vassiliki Magafa、Petros G. Tsoungas

  DOI：10.1055/s-2005-918426

  日期：——

  (ATPC) is an unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics. ATPC was obtained from both 3a and 3b thienopyrimidines by hydrolysis and hydrogenolysis, respectively. The synthesis of eleven ATPC-amino acids and two ATPC-peptides is described. ATPC is incorporated as N-terminal moiety in solution or solid-phase peptide synthesis using Boc or

  2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxy acid (4) (ATPC) 是一种非天然氨基酸，有望作为合成肽模拟物的构件。ATPC 分别通过水解和氢解从 3a 和 3b 噻吩并嘧啶中获得。描述了十一种ATPC-氨基酸和两种ATPC-肽的合成。使用 Boc 或 Fmoc 方法将 ATPC 作为 N 端部分引入溶液或固相肽合成中，而无需保护 ATPC 氨基。