2-(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)cyclohexan-1-one | 140654-22-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)cyclohexan-1-one
• CAS: 140654-22-4
• 化学式: C₁₀H₉ClF₈O
• 分子量: 332.621
• InChiKey: CRXJSAPFCSSDNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)cyclohexan-1-one 在 盐酸羟胺 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以82%的产率得到4,5-(1',4'-Butylene)-3-(3'-chlorohexafluoropropyl)isoxazole
  参考文献：
  名称：

  Synthesis of per(poly)fluoroalkylisoxazoles

  摘要：

  4,5-(1',4'-Butylene)-3-per(poly) fluoroalkylisoxazoles 2 are synthesized by the reaction of the alpha-per(poly) fluoroalkyl cyclohexanones 1 with hydroxylamine hydrochloride in the presence of potassium carbonate under reflux in ethanol. The isomeric 3,4-(1',4'-butylene)-5-per (poly) fluoroalkylisoxazoles 3 can be prepared by a reaction of 1, first with hydroxylamine hydrochloride to give the corresponding oximes 4, followed by the treatment of the resultant reaction mixture with potassium carbonate in a one-pot procedure.

  DOI：

  10.1016/0022-1139(95)03248-c
• 作为产物：
  描述：

  sodium 4-chloro-1,1,2,2,3,3,4,4-octafluorobutanesulfinate 、 环己烯 在 air 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以77%的产率得到2-(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)cyclohexan-1-one
  参考文献：
  名称：

  α-（全氟烷基）酮的新型合成

  摘要：

  在紫外线辐射和氧气气氛下，全卤代氟烷基亚磺酸钠与烯烃的反应以良好的收率提供了α-全卤代氟烷基酮。

  DOI：

  10.1016/s0022-1139(00)80336-x

文献信息

• One Pot Synthesis of Fluoroalkyl Pyrimidines from α-Fluoroalkyl Carbonyl Compounds, Orthoesters and Ammonium Carbonate
  作者：Bing-Hao Luo、Hui-Ping Guan、Chang-Ming Hu

  DOI：10.1055/s-1997-1031

  日期：1997.11

  Fluoroalkyl pyrimidines have been synthesized from one pot reaction of α-fluoroalkyl carbonyl compounds, orthoesters and ammonium carbonate. The possible reaction pathway is suggested.

  氟烷基嘧啶是由δ-氟烷基羰基化合物、原生酯和碳酸铵的一锅反应合成的。提出了可能的反应途径。
• Tang, Xiao-Qing; Hu, Chang-Ming, Journal of the Chemical Society. Perkin transactions I, 1995, # 8, p. 1039 - 1044
  作者：Tang, Xiao-Qing、Hu, Chang-Ming

  DOI：——

  日期：——
• A Novel Synthesis of 2-Fluoroalkyl Quinolines
  作者：Quan-Fu Wang、Yun-Yu Mao、Chao-Yue Qin、Shi-Zheng Zhu、Chang-Ming Hu

  DOI：10.1007/s007060050006

  日期：2000.1.15

  2-Fluoroalkyl quinolines are prepared by reacting aniline with alpha-fluoroalkyl aldehydes or alpha-fluoroalkyl cyclohexanones in the presence of acetic acid. Under the same reaction condition, 2-aminophenol gives the corresponding 2-fluoroalkyl-8-quinolinols; in some cases, 2-fluoroalkyl benzoxazoles are also formed as minor products.
• A novel synthesis of α-(perfluoroalkyl) ketones
  作者：Chang-Ming Hu、Xiao-Qing Tang、Feng-Ling Qing

  DOI：10.1016/s0022-1139(00)80336-x

  日期：1992.12

  Reaction of sodium perhalofluoroalkyl sulfinates with alkenes under UV irradiation and oxygen atmosphere provides α-perhalofluoroalkyl ketones in good yields.

  在紫外线辐射和氧气气氛下，全卤代氟烷基亚磺酸钠与烯烃的反应以良好的收率提供了α-全卤代氟烷基酮。
• Synthesis of per(poly)fluoroalkylisoxazoles
  作者：Xiao-Qing Tang、Chang-Ming Hu

  DOI：10.1016/0022-1139(95)03248-c

  日期：1995.9

  4,5-(1',4'-Butylene)-3-per(poly) fluoroalkylisoxazoles 2 are synthesized by the reaction of the alpha-per(poly) fluoroalkyl cyclohexanones 1 with hydroxylamine hydrochloride in the presence of potassium carbonate under reflux in ethanol. The isomeric 3,4-(1',4'-butylene)-5-per (poly) fluoroalkylisoxazoles 3 can be prepared by a reaction of 1, first with hydroxylamine hydrochloride to give the corresponding oximes 4, followed by the treatment of the resultant reaction mixture with potassium carbonate in a one-pot procedure.