(E)-2-phenyl-3H-indol-3-one O-methyl oxime | 1060712-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-2-phenyl-3H-indol-3-one O-methyl oxime
• 英文别名: 3-methoxyimino-2-phenyl-3H-indole；2-phenyl-indol-3-one-(O-methyl oxime )；2-Phenyl-indol-3-on-(O-methyl-oxim)；(E)-N-methoxy-2-phenylindol-3-imine
• CAS: 1060712-42-6
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: MNYUOTQYXGEQMV-BMRADRMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  34
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  溶剂黄146 、 palladium diacetate 、 (E)-2-phenyl-3H-indol-3-one O-methyl oxime 以 乙酸酐 、 溶剂黄146 为溶剂， 生成 (μ-acetato)2[Pd(κ2-C,N-3-methoxyimino-2-phenyl-3H-indole(-1H))]2 、 (μ-acetato)2[Pd(κ2-C,N-3-methoxyimino-2-phenyl-3H-indole(-1H))]2
  参考文献：
  名称：

  3-甲氧基亚氨基-2-苯基-3H-吲哚的环醇缩合

  摘要：

  3-甲氧基亚氨基-2-（4-氯苯基）-3H-吲哚（1a）和3-甲氧基亚氨基-2-苯基-3H-吲哚（1b）的直接环钯反应导致邻域σ[C（sp（sp）2，苯基）-H]键，得到（μ-OAC）2 [{钯κ 2 - C，N- ç 6 ħ 3 -4R -1-（C 8 H ^ 4 N-3“诺姆）}] 2（2）{R = Cl（2a）或H（2b）}包含一个中心“ Pd（μ-OAc）2 Pd”核。化合物2a和2b与三苯膦反应（摩尔比为PPh3：2  = 2），得到[{钯κ 2 - C，N- Ç 6 ħ 3 -4R -1-（C 8 H ^ 4的N- 3'-诺姆）}（OAC）（PPH 3）]（3） {R ＝ Cl（3a）或H（3b）}。的治疗图2a或2b中与丙酮稍微过量的LiCl产生的桥连配体的复分解和（μ-Cl）的形成2 [{钯κ 2 - C，N- Ç 6 ħ 3 -4R -1-（ C 8 H 4 N-3′-NOMe）}]

  DOI：

  10.1016/j.jorganchem.2008.05.043
• 作为产物：
  描述：

  2-苯基吲哚-3-酮 在 乙醇 、 盐酸羟胺 、 sodium methylate 、 sodium acetate 作用下， 生成 (E)-2-phenyl-3H-indol-3-one O-methyl oxime
  参考文献：
  名称：

  Social Psychological Models of Choice Behavior and Drivers' Left Turns

  摘要：

  The authors reanalyzed data from a simulated left-turn experiment (P A. Hancock, J. K. Caird, S. Shekhar, & M. Vercruyssen, 1991) to test the adequacy of the nonlinear Gray-Tallman satisfaction balance model of choice behavior (L. N. Gray & I. Tallman, 1984) in predicting left turns. Participants (Hancock et al., 1991) were 40 experienced U.S. drivers who were exposed to simulated oncoming traffic; the size of the vehicle (motorcycle, compact vehicle, full-sized vehicle, delivery truck), its speed (10-70 mph, or 16-112 kmph), and the intervehicle time gap (3-9 s) varied. Hancock et al. (1991) measured (a) the likelihood of a left turn and (b) the occurrence of a collision. The probability of a left turn was greater for larger intervehicle time gaps and for oncoming smaller vehicles traveling at higher speeds. The Gray-Tallman (1984) model explained 69% of the variation in turning versus 57% for a linear regression model. In making decisions people tend to treat the values and costs affecting choices in a multiplicative, rather than linear, fashion. The Gray-Tallman model also has the potential for incorporating, both theoretically and mathematically, an unlimited range of potential values and costs that may influence left turn decisions.

  DOI：

  10.1080/00224540109600583

文献信息

• Synthesis of 2-Aminobenzonitriles through Nitrosation Reaction and Sequential Iron(III)-Catalyzed C–C Bond Cleavage of 2-Arylindoles
  作者：Wei-Li Chen、Si-Yi Wu、Xue-Ling Mo、Liu-Xu Wei、Cui Liang、Dong-Liang Mo

  DOI：10.1021/acs.orglett.8b01294

  日期：2018.6.15

  were prepared from 2-arylindoles in good to excellent yields through tert-butylnitrite (TBN)-mediated nitrosation and sequential iron(III)-catalyzed C–C Bond cleavage in a one-pot fashion. The 2-aminobenzonitriles can be used to rapidly synthesize benzoxazinones by intramolecular condensation. The present method features an inexpensive iron(III) catalyst, gram scalable preparations, and novel C–C bond

  通过叔丁基亚硝酸盐（TBN）介导的亚硝化反应和连续铁（III）催化的C–C键裂解，以一锅方式从2-芳基吲哚制备了各种类型的2-氨基苯甲腈，产率高至优异。2-氨基苄腈可用于通过分子内缩合快速合成苯并恶嗪酮。本方法具有廉价的铁（III）催化剂，克级可缩放制备物和吲哚的新型C–C键裂解的特点。