N-[2-(4-羟基-3-甲氧基苯基)乙基]乙酰胺 | 10211-09-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-[2-(4-羟基-3-甲氧基苯基)乙基]乙酰胺
• 英文名称: N-acetyl-3-O-methyldopamine
• 英文别名: N-Acetyl-β-(4-hydroxy-3-methoxyphenyl)ethylamin；Acetamide, N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-；N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]acetamide
• CAS: 10211-09-3
• 化学式: C₁₁H₁₅NO₃
• mdl: MFCD00799019
• 分子量: 209.245
• InChiKey: LPMUFBLEYLSXFN-UHFFFAOYSA-N

物化性质

• 沸点：
  443.5±35.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟基-3-甲氧基苄醇 在 palladium on activated charcoal 盐酸 、 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.5h， 生成 N-[2-(4-羟基-3-甲氧基苯基)乙基]乙酰胺
  参考文献：
  名称：

  Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide

  摘要：

  Sixteen derivatives of N-acetyl-3-O-methyldopamine (NAMDA), an inhibitor of BH4 synthesis, were designed and synthesized. The ability of these derivatives to inhibit NO and BH4 production by lipopolysaccharide-stimulated BV-2 microglial cells was determined. While NAMDA at 100 mu M inhibited NO and BH4 production by only about 20%, its catecholamide 8, indole 23 derivative, 13, and N-acetyl tetrahydroisoquinoline 25 inhibited the NO production by > 50% at the same concentration. In particular, 13 and 25 inhibited both NO and BH4 production to similar degrees, which suggested that these compounds might inhibit NO production by blocking BH4-dependent dimerization of the newly synthesized iNOS monomer. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.033

文献信息

• [EN] 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS<br/>[FR] DERIVES DE 2-(6-AMINO-PYRIDINE-3-YL)-2-HYDROXYETHYLAMINE UTILISES COMME AGONISTES DES RECEPTEURS BETA 2-ADRENERGIQUES
  申请人：PFIZER LTD

  公开号：WO2004108676A1

  公开（公告）日：2004-12-16

  The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

  该发明涉及公式（1）的化合物，以及用于制备、用于制备的中间体、含有和用途的过程。根据本发明的化合物在许多疾病、紊乱和状况中特别有用，特别是在炎症性、过敏性和呼吸系统疾病、紊乱和状况中。
• Peg-based adhesive phenylic derivatives and methods of synthesis and use
  申请人：MURPHY John L.

  公开号：US20160032047A1

  公开（公告）日：2016-02-04

  The invention provides compositions that use phenylic derivatives to provide adhesive properties. Selection of phenylic derivatives with linkers or linking groups, and the linkages between the linkers or linking groups with polyalkylene oxides, provided herein may be configured to control curing time, biodegradation and/or swelling.

  本发明提供了使用苯基衍生物作为黏合剂的组合物。本发明提供了苯基衍生物与连接剂或连接基团的选择，以及连接剂或连接基团与聚烷氧化物之间的连接，可以配置以控制固化时间、生物降解和/或肿胀。
• NEUROPROTECTIVE COMPOUNDS AND USES THEREOF
  申请人：——

  公开号：US20010011146A1

  公开（公告）日：2001-08-02

  The present invention relates to a compound having the formula: 1 where X=R 1 O, F, Br, I, Cl, or a C 1 to C 5 alkyl group, R 1 =a C 1 to C 10 alkyl group or a C 1 to C 10 aryl group, n=1 or 2, R 2 =a C 1 to C 6 alkyl group, an amino acid, a heterocycle, a secondary or tertiary C 3 to C 4 hydrocarbon, or 2 where R 3 =H or CH 3 , or pharmaceutically-acceptable salts thereof. The invention further relates to pharmaceutical compositions which include the compounds, as well as methods of making and using the compounds.

  本发明涉及具有以下式子的化合物：1其中X = R1O、F、Br、I、Cl或C1至C5烷基，R1 = C1至C10烷基或C1至C10芳基，n = 1或2，R2 = C1至C6烷基、氨基酸、杂环、次生或三级C3至C4烃基，或2其中R3 = H或CH3，或其药学上可接受的盐。本发明还涉及包括所述化合物的药物组合物，以及制备和使用所述化合物的方法。
• 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS
  申请人：Pfizer Limited

  公开号：EP1633715A1

  公开（公告）日：2006-03-15
• [EN] NEUROPROTECTIVE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES NEUROPROTECTEURS ET LEURS APPLICATIONS
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：WO1998047498A1

  公开（公告）日：1998-10-29

  (EN) The present invention relates to a compound having formula (I) where X = R1O, F, Br, I, C1, or a C1 to C5 alkyl group; R1 = a C1 to C10 alkyl group or a C1 to C10 aryl group, n = 1 or 2, R2 = aC1 to C6 alkyl group, an amino acid, a heterocycle, a secondary or tertiary C3 to C4 hydrocarbon, or (a) where R3 = H or CH3, or pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions which include the compounds, as well as methods of making and using the compounds.(FR) Cette invention porte sur un composé répondant à la formule: (I) dans laquelle X représente R1O, F, Br, I, Cl ou un groupe alkyle comportant de 1 à 5 atomes de carbone, R1 représente un groupe alkyle comportant de 1 à 10 atomes de carbone ou un groupe aryle comportant de 1 à 10 atomes de carbone, n vaut 1 ou 2, R2 représente un groupe alkyle comportant de 1 à 6 atomes de carbone, un acide aminé, un hétérocycle, un hydrocarbure secondaire ou tertiaire comportant de 3 à 4 atomes de carbone ou représente la formule (a), formule dans laquelle R3 représente H ou CH3. L'invention, qui concerne également les sels de ce composé, acceptables du point de vue pharmaceutique, porte, en outre, sur des compositions pharmaceutiques renfermant ces composés ainsi que sur leurs techniques de production et d'utilisation.