2,4-dibromo-6-(1H-tetrazol-5-yl)aniline | 202341-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,4-dibromo-6-(1H-tetrazol-5-yl)aniline
• 英文别名: 2,4-dibromo-6-tetrazolylaniline；2,4-dibromo-6-(1H-tetrazol-5-yl)-aniline；2,4-dibromo-6-(2H-tetrazol-5-yl)aniline
• CAS: 202341-04-6
• 化学式: C₇H₅Br₂N₅
• 分子量: 318.958
• InChiKey: TWLOJENVCJQGFQ-UHFFFAOYSA-N

物化性质

• 沸点：
  464.5±55.0 °C(Predicted)
• 密度：
  2.164±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dibromo-6-(1H-tetrazol-5-yl)aniline 、 对甲氧基苯异氰酸酯 以 四氢呋喃 为溶剂， 反应 21.0h， 以19%的产率得到N-[4-methoxyphenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
  参考文献：
  名称：

  ジフェニル尿素化合物誘導体

  摘要：

  【课题】提供参与植物离子载体功能调控的新型二苯基尿素化合物衍生物。【解决手段】如下式（1）（式中符号按说明书中记载）所示的二苯基尿素化合物衍生物。【选择图】无

  公开号：

  JP2021024832A
• 作为产物：
  描述：

  2-氨基-3,5-二溴苯腈 在 叠氮基三甲基硅烷 、 四丁基氟化铵 作用下， 反应 2.0h， 以44%的产率得到2,4-dibromo-6-(1H-tetrazol-5-yl)aniline
  参考文献：
  名称：

  植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法

  摘要：

  【课题】筛选具有针对植物运输体的功能调控活性的二苯基尿素化合物诱导剂，并提供植物钾离子运输体的功能调控剂，以及提供使用该植物钾离子运输体功能调控剂施用于植物的改良植物体的培养方法。 【解决方案】包含以下一般式（1）（式中的符号如说明书所述）所示的化合物诱导剂（NS5806类）的植物钾离子运输体的功能调控剂，以及使用所述功能调控剂施用于植物的植物培养方法。 【选择图】无

  公开号：

  JP2019137678A

文献信息

• Diarylurea derivatives and their use as chloride channel blockers
  申请人：Dahl H Bjarne

  公开号：US20060160856A1

  公开（公告）日：2006-07-20

  The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及新型二芳基脲衍生物，其作为氯离子通道阻滞剂有用。在其他方面，本发明涉及这些化合物在治疗方法中的使用，例如用于骨代谢性疾病、对肥大细胞或嗜碱性粒细胞活性调节敏感的疾病、对血管生成抑制敏感的疾病或镰刀细胞贫血的治疗，以及包含本发明化合物的制药组合物。
• Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2
  作者：A Lundby、T Jespersen、N Schmitt、M Grunnet、S-P Olesen、JM Cordeiro、K Calloe

  DOI：10.1111/j.1476-5381.2010.00859.x

  日期：2010.8

  BACKGROUND AND PURPOSEThe compound NS5806 increases the transient outward current (Ito) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, Ito is thought to be mediated by KV4.3 and various ancillary proteins, yet, the exact subunit composition of Ito channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative Ito channel subunits and other potassium channels.EXPERIMENTAL APPROACHCloned KV4 channels were co‐expressed with KChIP2, DPP6, DPP10, KCNE2, KCNE3 and KV1.4 in Xenopus laevis oocytes or CHO‐K1 cells.KEY RESULTSNS5806 increased KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 ± 1.5µM and significantly slowed current decay. KCNE2, KCNE3, DPP6 and DPP10 modulated KV4.3 currents and the response to NS5806, but current decay was slowed only in complexes containing KChIP2. The effect of NS5806 on KV4.2 was similar to that on KV4.3, and current decay was only slowed in presence of KChIP2. However, for KV4.1, the slowing of current decay by NS5806 was independent of KChIP2. KV1.4 was strongly inhibited by 10 µM NS5806 and KV1.5 was inhibited to a smaller extent. Effects of NS5806 on kinetics of currents generated by KV4.3/KChIP2/DPP6 with KV1.4 in oocytes could reproduce those on cardiac Ito in canine ventricular myocytes. KV7.1, KV11.1 and Kir2 currents were unaffected by NS5806.CONCLUSION AND IMPLICATIONSNS5806 modulated KV4 channel gating depending on the presence of KChIP2, suggesting that NS5806 can potentially be used to address the molecular composition as well as the physiological role of cardiac Ito.
• DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS
  申请人：NeuroSearch A/S

  公开号：EP1537075B1

  公开（公告）日：2009-07-01