3-(4-acetoxy-phenyl)-1-(2,4-diacetoxy-6-hydroxy-phenyl)-propan-1-one | 76344-03-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-acetoxy-phenyl)-1-(2,4-diacetoxy-6-hydroxy-phenyl)-propan-1-one
• 英文别名: 3-(4-Acetoxy-phenyl)-1-(2,4-diacetoxy-6-hydroxy-phenyl)-propan-1-on；[4-[3-(2,4-Diacetyloxy-6-hydroxyphenyl)-3-oxopropyl]phenyl] acetate
• CAS: 76344-03-1
• 化学式: C₂₁H₂₀O₈
• 分子量: 400.385
• InChiKey: KJCUXLKEGFYULO-UHFFFAOYSA-N

物化性质

• 沸点：
  591.5±50.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯仿 、 氢溴酸 、 溶剂黄146 作用下， 生成 3-(4-acetoxy-phenyl)-1-(2,4-diacetoxy-6-hydroxy-phenyl)-propan-1-one
  参考文献：
  名称：

  Zemplen et al., Chemische Berichte, 1928, vol. 61, p. 2492

  摘要：

  DOI：

文献信息

• Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans
  申请人：——

  公开号：US20030162753A1

  公开（公告）日：2003-08-28

  The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.

  化合物的化学式（I）为亲水性芳基磷酸酯、硫代磷酸酯和氨基磷酸酯，是肠道顶端膜Na介导的磷酸盐共同运输抑制剂。这些化合物可以经口服给药，在肠道中起到抑制Na依赖性磷酸盐摄取的作用，或者内部给药，在肾脏和甲状旁腺的磷酸盐控制功能中发挥作用。它们可用于抑制钠介导的磷酸盐摄取，降低血清PTH、钙、钙三醇和磷酸盐，治疗动物（包括人类）的肾脏疾病。
• Inhibitors of intestinal apical membrane Na/phosphate co-transportation
  申请人：——

  公开号：US20020133036A1

  公开（公告）日：2002-09-19

  The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.

  式（I）的化合物是亲水性芳基磷酸酯、硫代磷酸酯和氨基磷酸酯肠道顶端膜Na介导的磷酸共运输抑制剂。这些化合物可通过口服给药，在肠道内起到抑制依赖Na的磷酸摄取的作用，或在体内与肾脏和甲状旁腺的磷酸控制功能相互作用。因此，它们对于抑制钠介导的磷酸摄取、降低血清PTH、钙、活性维生素D和磷酸盐，以及治疗动物（包括人类）的肾脏疾病非常有用。
• Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity
  作者：Alicia Hermoso、Ignacio A Jiménez、Zulma A Mamani、Isabel L Bazzocchi、José E Piñero、Angel G Ravelo、Basilio Valladares

  DOI：10.1016/s0968-0896(03)00406-1

  日期：2003.9

  Two dihydrochalcones (1 and 2) were isolated from Piper elongatum Vahl by activity-guided fractionation against extracellular promastigotes of Leishmania braziliensis in vitro. Their structures were elucidated by spectral analysis, including homonuclear and heteronuclear correlation NMR experiments. Derivatives 3-7 and 20 synthetic related compounds (8-27) were also assayed to establish the structural requirements for antileishmanial activity. Compounds 1-11 that proved to be more active that ketoconazol, used as positive control, were further assayed against promastigotes of Leishmania tropica and Leishmania infantum. Compounds 7 and 11, with a C-6-C-3-C-6 System, proved to be the most promising compounds, with IC50 values of 2.98 and 3.65 mug/mL, respectively, and exhibited no toxic effect on macrophages (around 90% viability). Correlation between the molecular structures and antileishmanial activity is discussed in detail. (C) 2003 Elsevier Ltd. All rights reserved.
• INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION
  申请人：BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

  公开号：EP1175425A2

  公开（公告）日：2002-01-30
• US6355823B1
  申请人：——

  公开号：US6355823B1

  公开（公告）日：2002-03-12