(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoic酸 | 68378-49-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoic酸
• 英文名称: (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoic acid
• 英文别名: (all-Z)-6,9,12,15,18,21-tetracosahexaenoic acid；Nisinic acid
• CAS: 68378-49-4
• 化学式: C₂₄H₃₆O₂
• 分子量: 356.549
• InChiKey: YHGJECVSSKXFCJ-KUBAVDMBSA-N

物化性质

• 沸点：
  470.5±14.0 °C(Predicted)
• 密度：
  0.935±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：50mg/mL； DMSO：50mg/mL；乙醇：50mg/mL； PBS（pH 7.2）：0.1 mg/mL
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoic酸 在 4-二甲氨基吡啶 、 Lipase PS 、 2,6-二叔丁基-4-甲基苯酚 、 N,N'-二环己基碳二亚胺 作用下， 以 异丙醚 为溶剂， 反应 3.0h， 生成 2-O-tert-butyldimethylsilyl-1-tetracosa (all Z)-6,9,12,15,18,21-hexaenoyl-sn-glycerol
  参考文献：
  名称：

  A first synthesis of a phosphatidylcholine bearing docosahexaenoic and tetracosahexaenoic acids

  摘要：

  一种新型的磷脂酰胆碱首次通过新方法合成，该磷脂酰胆碱在1位和2位分别带有二十四碳六烯酸[24∶6 (n-3)]和二十二碳六烯酸[22∶6 (n-3), DHA]。

  DOI：

  10.1039/b007923p
• 作为产物：
  描述：

  [(3Z,6Z)-9,9-dimethoxynona-3,6-dien-1-yl]triphenylphosphonium iodide 在 六甲基磷酰三胺 、 甲酸 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 5.5h， 生成 (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoic酸
  参考文献：
  名称：

  A nine carbon homologating system for skip-conjugated polyenes

  摘要：

  Ozonolysis of Z,Z,Z-cylonona-1,4,7-triene leads to a 1,9-difunctionalised Z,Z-3,6-nonadiene which is readily converted into a range of polyunsaturated pheromones and fatty acids. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2014.04.005

文献信息

• [EN] PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-6 FATTY ACIDS<br/>[FR] PROCÉDÉ D'AUGMENTATION DE LA STABILITÉ D'UNE COMPOSITION COMPRENANT DES ACIDES GRAS OMÉGA-6 POLYINSATURÉS
  申请人：EVONIK DEGUSSA GMBH

  公开号：WO2016102316A1

  公开（公告）日：2016-06-30

  The present invention relates to processes for increasing the stability of compositions comprising polyunsaturated omega-6 fatty acids against oxidation. The processes comprise the following steps: (i) providing a starting composition comprising at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing aqueous, aqueous-alcoholic or alcoholic solutions of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition comprising at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC < 5 wt%, SC < 3 wt%, SC < 1 wt%, SC < 0.5 wt%. Compositions obtainable by such spray drying processes and use of such compositions for the manufacture of food, nutritional and pharmaceutical products are further comprised by the present invention.

  本发明涉及增加含有多不饱和ω-6脂肪酸的组合物抗氧化稳定性的过程。该过程包括以下步骤：(i)提供包含至少一种多不饱和ω-6脂肪酸成分的起始组合物；(ii)提供赖氨酸组合物；(iii)混合起始组合物和赖氨酸组合物的水、水醇或醇溶液，并随后将所得混合物暴露于喷雾干燥条件，从而形成包含至少一种来自赖氨酸阳离子和来自多不饱和ω-6脂肪酸阴离子的盐的固体产品组合物；所述产品组合物具有以下所选的溶剂含量SC：SC < 5 wt%，SC < 3 wt%，SC < 1 wt%，SC < 0.5 wt%。通过这种喷雾干燥过程获得的组合物以及利用这种组合物制造食品、营养和制药产品的方法也包含在本发明中。
• AMINO ACID SALTS OF UNSATURATED FATTY ACIDS
  申请人：Thetis Pharmaceuticals LLC

  公开号：US20170119841A1

  公开（公告）日：2017-05-04

  The present invention provides compounds of Formula I and Formula II and related compositions and methods.

  本发明提供了Formula I和Formula II的化合物以及相关的组合物和方法。
• [EN] HERBICIDAL PYRAZINONES<br/>[FR] PYRAZINONES HERBICIDES
  申请人：DU PONT

  公开号：WO2012148622A1

  公开（公告）日：2012-11-01

  Disclosed are compounds of Formula (1), including all stereoisomers, N oxides, and salts thereof, wherein A is a radical selected from the group consisting of and B1, B2, B3, T, R1, R2 R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention. Also disclosed are compounds useful as intermediates for preparing compounds of Formula (1).

  揭示了Formula（1）的化合物，包括所有立体异构体、N-氧化物和盐，其中A是从B1、B2、B3、T、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13和R14组成的基团之一，如所述所定义。还揭示了含有Formula 1的化合物的组合物，以及用于控制不良植被的方法，包括将不良植被或其环境与本发明的化合物或组合物的有效量接触。还揭示了作为制备Formula（1）化合物的中间体有用的化合物。
• [EN] HERBICIDAL PYRIMIDONE DERIVATIVES<br/>[FR] DÉRIVÉS HERBICIDES DE PYRIMIDONE
  申请人：DU PONT

  公开号：WO2011031658A1

  公开（公告）日：2011-03-17

  Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, Formula : (I) X is CH or N; Y is C(O) or S(O)2; provided that when Y is S(O)2, then X is CH; A is a radical selected from the group consisting of Formula : A-1, A-2, A-3, A-4, A-5, A-6, A-7 and B1, B2, B3, T, R1, R2 R3, R4, R5, R6, R7, R8, R9 R10 R11 R12 and R13 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

  揭示了Formula（1）的化合物，包括所有立体异构体、N-氧化物和盐，化学式：（I）X为CH或N；Y为C（O）或S（O）2；但当Y为S（O）2时，X为CH；A是从Formula组成的一组中选择的基团：A-1、A-2、A-3、A-4、A-5、A-6、A-7和B1、B2、B3、T，R1、R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12和R13如披露中定义的那样。还揭示了含有Formula（1）化合物的组合物以及用于控制不受欢迎的植被的方法，包括将不受欢迎的植被或其环境与本发明的化合物或组合物的有效量接触。
• [EN] PEPTIDE INHIBITORS OF FOCAL ADHESION KINASE ACTIVITY AND USES THEREOF<br/>[FR] INHIBITEURS PEPTIDIQUES DE L'ACTIVITÉ DE KINASE D'ADHÉRENCE FOCALE ET UTILISATION ASSOCIÉES
  申请人：UNIV ARIZONA

  公开号：WO2021042064A1

  公开（公告）日：2021-03-04

  This disclosure provides peptides which have an affinity for the focal adhesion targeting (FAT) domain of focal adhesion kinase (FAK). In particular, the peptides are modified and derived from the sequence of the LD2 alpha helical domain of paxillin (e.g., LD2 peptides), the LD4 domain of paxillin (e.g., LD4 peptides), and CD8 peptides. These peptides are capable of blocking an interaction between paxillin and FAK, thereby inhibiting FAK activity related to FAK-paxillin interaction. The invention further provides uses for such peptides as therapeutics for the treatment of cancer and other diseases characterized with FAK activity and/or expression (e.g., fibrosis).

  本公开提供了对焦粘附激酶（FAK）的焦粘附靶向（FAT）结构域具有亲和力的肽。具体来说，这些肽经过修改并来源于paxillin的LD2α螺旋结构域序列（例如LD2肽）、paxillin的LD4结构域（例如LD4肽）和CD8肽。这些肽能够阻断paxillin与FAK之间的相互作用，从而抑制与FAK-paxillin相互作用相关的FAK活性。该发明进一步提供了这些肽作为治疗癌症和其他具有FAK活性和/或表达（例如纤维化）特征的疾病的治疗药物的用途。