tagatose (α-furanose) | 36441-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tagatose (α-furanose)
• 英文别名: α-D-tagatofuranose；D-tagatose；fructose；tagatose；D-tagatose；α-D-tagatofuranose；alpha-D-tagatofuranose；(2S,3S,4R,5R)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol
• CAS: 36441-92-6
• 化学式: C₆H₁₂O₆
• 分子量: 180.158
• InChiKey: RFSUNEUAIZKAJO-VANKVMQKSA-N

物化性质

• 熔点：
  162 °C
• 沸点：
  440.1±45.0 °C(Predicted)
• 密度：
  1.694±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tagatose (α-furanose) 在 硫酸 、 水 作用下， 137.0 ℃ 、2.0 MPa 条件下， 生成 5-羟甲基糠醛
  参考文献：
  名称：

  不同的酮和醛脱水为5-羟甲基糠醛

  摘要：

  5-羟甲基糠醛（HMF）被认为是未来生物基化学品的重要组成部分。在这里，我们提供了在水性酸性条件下（65 g L -1底物，100–160°C，33–300 m M H ）使用不同的酮糖（果糖，山梨糖，塔格糖）和醛糖（葡萄糖，甘露糖，半乳糖）进行的实验研究。  2 SO 4）以深入了解己糖脱水成HMF的反应途径。酮糖的反应速率和HMF选择性均明显高于醛糖，这与文献一致。筛选和动力学实验表明，不同酮糖的反应性是C3和C4位置羟基方向的函数。这些结果与DFT计算相结合，指出了涉及环状中间体的脱水机理。对于醛糖，没有观察到羟基取向的影响，表明不同的速率确定步骤。来自文献的知识和这项工作中的发现相结合表明，醛糖在脱水之前需要异构化成酮糖才能获得高HMF收率。

  DOI：

  10.1002/cssc.201300345

文献信息

• CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20140286943A1

  公开（公告）日：2014-09-25

  The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.

  本发明涉及P2Y12受体活性的新的环丙基调节剂，其制药组合物以及使用方法。
• Dehydration of fructose to HMF in presence of (H3O)xSbxTe(2-x)O6 (x = 1, 1.1, 1.25) in H2O-MIBK
  作者：Sergio F. Mayer、H. Falcón、R. Dipaola、P. Ribota、L. Moyano、S. Morales-delaRosa、R. Mariscal、J.M. Campos-Martín、J.A. Alonso、J.L.G. Fierro

  DOI：10.1016/j.mcat.2018.12.025

  日期：2020.2

  The pyrochlores (H3O)(x)SbxTe(2-x)O6 (x = 1, 1.1 and 1.25) obtained by ion exchange from KxSbxTe(2-x)O6 oxides were used as catalysts for the conversion of fructose to 5-hydroxymethylfurfural (HMF) in H2O/Methyl isobutyl ketone (MIBK). The structure of the resulting compounds as well as the location of the H3O+ units inside the three-dimensional network, were determined by XRD from powder samples. The effect of factors such as reaction time and temperature on the formation of HMF was studied. A fructose conversion of 99% and a yield of 59% were achieved after 120 min of reaction time and at 150 degrees C temperature. The percentage of substitution of the cations Sb and Te in the position B of the pyrochlore was determinant to achieve the maximum incorporation of H3O+ ions in the pyrochlore structure, which allowed to correlate the density of acidic sites present in the materials and their catalytic activity.
• 10.1080/bbb.58.2168
  作者：Itoh、Okaya、Khan、Tajima、Hayakawa、Izumori

  DOI：10.1080/bbb.58.2168

  日期：——
• ENDOSPORE COMPOSITIONS AND USES THEREOF
  申请人：Annuary Healthcare Inc.

  公开号：US20140178496A1

  公开（公告）日：2014-06-26

  Provided herein in some embodiments is a composition that comprises (a) a nanoscale particle(s) or a microscale particle(s); and (b) a film-forming polymer. Also provided herein is a method for an immediate and sustained released formulation suitable for topical administration or administration to surfaces. Further provided herein in certain embodiments is a method of reducing the population of pathogenic microorganisms on skin or surfaces, wherein a method comprises applying to the skin or surface a composition, wherein the composition comprises (a) a nanoscale particle(s) or a microscale particle(s); and (b) a film-forming polymer.