6-chloro-8-cyclopentenyl-1,2-dihydro-2,2,4-trimethylquinoline | 1492019-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-8-cyclopentenyl-1,2-dihydro-2,2,4-trimethylquinoline
• 英文别名: 6-chloro-8-(cyclopenten-1-yl)-2,2,4-trimethyl-1H-quinoline
• CAS: 1492019-84-7
• 化学式: C₁₇H₂₀ClN
• 分子量: 273.806
• InChiKey: CIYKTSVURVXXCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对氯苯胺 在 碘 作用下， 以 甲苯 为溶剂， 反应 72.0h， 生成 6-chloro-8-cyclopentenyl-1,2-dihydro-2,2,4-trimethylquinoline
  参考文献：
  名称：

  Iodine-catalyzed cycloalkenylation of dihydroquinolines and arylamines through a reaction with cyclic ketones under neat conditions

  摘要：

  An iodine-catalyzed direct cycloalkenylation of dihydroquinolines and arylamines has been developed. This method consists of a Friedel-Crafts reaction between dihydroquinolines (or arylamines) and cyclic ketones in which the double bond is selectively generated throughout the course of the reaction resulting in a direct cycloalkenylation, under neat conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.10.081

文献信息

• Iodine-catalyzed cycloalkenylation of dihydroquinolines and arylamines through a reaction with cyclic ketones under neat conditions
  作者：Jean Fotie、Suraj K. Ayer、Binit S. Poudel、Carolyn S. Reid

  DOI：10.1016/j.tetlet.2013.10.081

  日期：2013.12

  An iodine-catalyzed direct cycloalkenylation of dihydroquinolines and arylamines has been developed. This method consists of a Friedel-Crafts reaction between dihydroquinolines (or arylamines) and cyclic ketones in which the double bond is selectively generated throughout the course of the reaction resulting in a direct cycloalkenylation, under neat conditions. (C) 2013 Elsevier Ltd. All rights reserved.