bis(benzo[d][1,3]dioxol-5-yl)methane | 4971-68-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: bis(benzo[d][1,3]dioxol-5-yl)methane
• 英文别名: bis(3,4-methylenedioxyphenyl)methane；bis-benzo[1,3]dioxol-5-yl-methane；Bis-benzo[1,3]dioxol-5-yl-methan；5,5'-Methylenebis(2H-1,3-benzodioxole)；5-(1,3-benzodioxol-5-ylmethyl)-1,3-benzodioxole
• CAS: 4971-68-0
• 化学式: C₁₅H₁₂O₄
• 分子量: 256.258
• InChiKey: HLLPPZWIJLBKHR-UHFFFAOYSA-N

物化性质

• 熔点：
  147 °C
• 沸点：
  388.8±37.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(benzo[d][1,3]dioxol-5-yl)methane 在 硝酸 、 溶剂黄146 作用下， 生成 bis-(6-nitro-benzo[1,3]dioxol-5-yl)-methane
  参考文献：
  名称：

  Garofano; Oliverio, Annali di Chimica, 1957, vol. 47, p. 896,904

  摘要：

  DOI：
• 作为产物：
  描述：

  bis-benzo[1,3]dioxol-5-yl-hydroxy-acetic acid 在 chromium(VI) oxide 、 乙醇 、 sodium 、 溶剂黄146 作用下， 生成 bis(benzo[d][1,3]dioxol-5-yl)methane
  参考文献：
  名称：

  Garofano; Oliverio, Annali di Chimica, 1957, vol. 47, p. 896,904

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE<br/>[FR] COMPOSES, COMPOSITIONS ET PROCEDES DE TRAITEMENT DE MALADIES AMYLOIDES ET DE SYNUCLEINOPATHIES, NOTAMMENT DE LA MALADIE D'ALZHEIMER, DU DIABETE DE TYPE 2 ET DE LA MALADIE DE PARKINSON
  申请人：PROTEOTECH INC

  公开号：WO2003101927A1

  公开（公告）日：2003-12-11

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aß amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinophathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药用可接受酯，它们的合成，含有它们的药物组合物，以及它们在治疗淀粉样疾病，特别是Aß淀粉样病变，如阿尔茨海默病中观察到的，IAPP淀粉样病变，如2型糖尿病中观察到的，以及α-突触核病，如帕金森病中观察到的，以及用于制造用于此类治疗的药物。
• Synthesis of Cycloveratrylene Macrocycles and Benzyl Oligomers Catalysed by Bentonite under Microwave/Infrared and Solvent-Free Conditions
  作者：René Miranda、Omar Valencia-Vázquez、Carlos Maya-Vega、Inés Nicolás-Vázquez、Yolanda Vargas-Rodriguez、José Morales-Serna、Eréndira García-Ríos、Manuel Salmón

  DOI：10.3390/molecules181012820

  日期：——

  Tonsil Actisil FF, which is a commercial bentonitic clay, promotes the formation of cycloveratrylene macrocycles and benzyl oligomers from the corresponding benzyl alcohols in good yields under microwave heating and infrared irradiation in the absence of solvent in both cases. The catalytic reaction is sensitive to the type of substituent on the aromatic ring. Thus, when benzyl alcohol was substituted with a methylenedioxy, two methoxy or three methoxy groups, a cyclooligomerisation process was induced. Unsubstituted, methyl and methoxy benzyl alcohols yielded linear oligomers. In addition, computational chemistry calculations were performed to establish a validated mechanistic pathway to explain the growth of the obtained linear oligomers.

  Tonsil Actisil FF是一种商业膨润土，在无溶剂的情况下，通过微波加热和红外辐射促进了环苯乙烯大环和相应苯基醇的苄基寡聚物的形成，产率良好。催化反应对于芳环上取代基的类型比较敏感。因此，当苄基醇被甲撑二氧基、两个甲氧基或三个甲氧基取代时，诱导了环状寡聚过程。而未取代的、甲基和甲氧基苄基醇则产生了线性寡聚物。此外，进行了计算化学计算，以建立一个经过验证的机制路径，以解释所获得的线性寡聚物的生长。
• Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water
  作者：Jin Zhang、Jihong Du、Chenyang Zhang、Kun Liu、Feifei Yu、Yongkun Yuan、Baogen Duan、Renhua Liu

  DOI：10.1021/acs.orglett.1c04154

  日期：2022.2.11

  Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes with water as the only oxygen donor is reported. This C–H bond oxidation functionalization does not require other oxidants and hydrogen acceptors, and H2 is the only byproduct. The oxygen atom introduced into the products is confirmed to be from water by the MS analysis on the product of

  这里报道了一种钯催化的氧化方法，用于将烷基芳烃转化为芳族酮或苯甲醛，水作为唯一的氧供体。这种 C-H 键氧化功能化不需要其他氧化剂和氢受体，H 2是唯一的副产物。通过对18 O-标记水反应的产物进行 MS 分析，确认了引入产物中的氧原子来自水。
• Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and parkinson's disease
  申请人：——

  公开号：US20040127555A1

  公开（公告）日：2004-07-01

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A&bgr; amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双和三羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成方法，包含它们的药物组成物，以及它们在治疗淀粉样疾病中的应用，特别是Aβ淀粉样蛋白病，如阿尔茨海默病，IAPP淀粉样蛋白病，如2型糖尿病中观察到的，以及突触核蛋白病，如帕金森病中观察到的，以及用于制造此类治疗药物。
• Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
  申请人：Snow D. Alan

  公开号：US20070225362A1

  公开（公告）日：2007-09-27

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双羟基和三羟基芳基化合物及其甲氧基二氧杂环化物和药学上可接受的酯类，它们的合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病，特别是阿尔茨海默病中观察到的Aβ淀粉样变性，IAPP淀粉样变性，例如在2型糖尿病中观察到的AA / SAA淀粉样变性，以及突触蛋白病，例如在帕金森病中观察到的应用，以及用于制造这种治疗药物。