3-(15-hydroxypentadecyl)-4-methyl-2-cyclohexen-1-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(15-hydroxypentadecyl)-4-methyl-2-cyclohexen-1-one
• 英文别名: 3-(15-Hydroxypentadecyl)-4-methylcyclohex-2-en-1-one
• 化学式: C₂₂H₄₀O₂
• 分子量: 336.558
• InChiKey: CWZACLGIXULVCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methyl-2-cyclohexenone 在 盐酸 、 正丁基锂 、 三苯基甲烷 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 、 氯仿 、 水 、 丙酮 、 苯 为溶剂， 反应 55.0h， 生成 3-(15-hydroxypentadecyl)-4-methyl-2-cyclohexen-1-one
  参考文献：
  名称：

  Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators

  摘要：

  神经营养因子在神经元的发育和维持中起着重要作用，因此为治疗神经退行性疾病提供了合适的疗法。然而，由于存在一系列技术和生物学上的缺点，它们在临床应用中遇到了问题。在提出的不同克服这些困难的策略中，寻找具有神经营养潜力的非肽类物质正取得令人鼓舞的成果。本文将展示该领域的主要发现，特别关注环己烯型长链脂肪醇，这是一个促进神经元存活和神经突延伸的新型化合物家族。

  DOI：

  10.3390/51201439

文献信息

• Stem cell differentiation-inducing promoter
  申请人：——

  公开号：US20040115810A1

  公开（公告）日：2004-06-17

  Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group]. Since the cyclohexenone long-chain alcoholic derivative according to the present invention promotes differentiation-induction of stem cells into cells expressing a specific biological function, a medicament comprising the derivative is useful as a preventive or remedial drug for diseases such as nervous diseases, bone diseases, circulatory diseases and myopathy, caused by the degeneration of tissues or cells or cell death. 1

  提供的是一种干细胞分化和诱导促进剂，其有效成分为由式（1）表示的环己烯酮长链醇衍生物：[其中，R1、R2和R3分别独立表示氢原子或甲基基团，X表示线性或支链C10-28烷基或烯基基团]。根据本发明的环己烯酮长链醇衍生物促进干细胞向表达特定生物功能的细胞分化诱导，包含该衍生物的药物可用作预防或治疗神经疾病、骨疾病、循环系统疾病和肌病等由组织或细胞退化或细胞死亡引起的疾病的药物。
• [EN] USE OF CYCLOHEXENONE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT IN THE TREATMENT OF DYSURIA<br/>[FR] UTILISATION DE DERIVES DE CYCLOHEXENONE POUR LA PREPARATION D'UN MEDICAMENT PERMETTANT DE TRAITER LA DYSURIE
  申请人：MEIJI DAIRIES CORP

  公开号：WO2002066024A1

  公开（公告）日：2002-08-29

  A preventive and/or therapeutic agent for dysuria, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1):[wherein, R?1, R2 and R3¿ each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C¿10-28? alkylene or alkenylene group].This compound alleviates dysuria due to hypofunction of the urinary bladder so that they are useful as a preventive and/or therapeutic agent for dysuria.

  一种预防和/或治疗尿痛的药物，其有效成分为下式（1）所表示的环己烯酮长链醇衍生物：[其中，R1、R2和R3各自独立地表示氢原子或甲基基团，X表示线性或支链C10-28烷基或烯基烷基]。该化合物缓解因膀胱低功能引起的尿痛，因此它们可用作预防和/或治疗尿痛的药物。
• [EN] USE OF A CYCLOHEXENONE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR TREATING DIABETIC COMPLICATIONS<br/>[FR] UTILISATION DE DERIVES DE CYCLOHEXENONE DANS LA FABRICATION D'UN MEDICAMENT DESTINE AU TRAITEMENT DE COMPLICATIONS DIABETIQUES
  申请人：MEIJI DAIRIES CORP

  公开号：WO2002066023A1

  公开（公告）日：2002-08-29

  A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R?1, R2 and R3¿ each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C¿10-28? alkylene or alkenylene group. The cyclohexenone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy.

  预防和/或治疗糖尿病并发症的药剂，其有效成分为以下公式（1）所表示的环己烯酮长链醇衍生物：其中，R?1，R2和R3¿各自独立表示氢原子或甲基基团，X表示线性或支链C¿10-28?烷基或烯基基团。本发明的环己烯酮长链醇衍生物显著抑制了周围神经传导速率的降低，并缓解了膀胱的低功能，因此可用作预防和/或治疗糖尿病并发症，特别是糖尿病神经病变的药剂。
• Use of cyclohexenone derivatives in the manufacture of a medicament for treating diabetic complications
  申请人：——

  公开号：US20040102527A1

  公开（公告）日：2004-05-27

  A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C 10-28 alkylene or alkenylene group. The cyclohcxcnone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy. 1

  一种用于糖尿病并发症的预防和/或治疗剂，其有效成分为以下式（1）所表示的环己烯酮长链醇衍生物，其中R1、R2和R3各自独立地表示氢原子或甲基基团，X表示线性或支链的C10-28烷基或烯基基团。本发明的环己烯酮长链醇衍生物显著抑制了外周神经传导速度的降低，缓解了膀胱的低功能，因此可用作糖尿病并发症的预防和/或治疗剂，特别是用于糖尿病神经病变。
• Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria
  申请人：——

  公开号：US20040132829A1

  公开（公告）日：2004-07-08

  A preventive and/or therapeutic agent for dysuria, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1):[wherein, R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C 10-28 alkylene or alkenylene group]. This compound alleviates dysuria due to hypofunction of the urinary bladder so that they are useful as a preventive and/or therapeutic agent for dysuria. 1

  一种预防和/或治疗排尿困难的药物，其有效成分为以下式（1）所表示的环己烯酮长链醇衍生物：[其中，R1、R2和R3各自独立地表示氢原子或甲基基团，X表示线性或支链C10-28烷基或烯基基团]。该化合物缓解由于膀胱功能低下引起的排尿困难，因此它们是预防和/或治疗排尿困难的有用药物。