methyl 2-β-D-ribofuranosyl-thiazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-β-D-ribofuranosyl-thiazole-4-carboxylate
• 英文别名: 2-β-D-ribofuranosylthiazole-4-carboxylic acid, methyl ester；methyl 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxylate
• 化学式: C₁₀H₁₃NO₆S
• 分子量: 275.282
• InChiKey: VAZMWZPZBBMCQF-WCTZXXKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  methyl 2-β-D-ribofuranosyl-thiazole-4-carboxylate 生成 噻唑呋林
  参考文献：
  名称：

  PARSONS, J. L.;VIZINE, D.;SUMNER, M.;MARATHE, S.;DUBICKI, H.

  摘要：

  DOI：
• 作为产物：
  描述：

  甲醇 、 ethyl 2-(2',3',3''-tri-O-benzoyl-β-D-apiofuranosyl)thiazole-4-carboxylate 在 sodium methylate 作用下， 生成 methyl 2-β-D-ribofuranosyl-thiazole-4-carboxylate
  参考文献：
  名称：

  Design, synthesis and antiproliferative activity of methyl 4-Iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds

  摘要：

  In a SAR study on azole-related nucleosides we have designed some pyrazole-nucleoside analogs characterised, for the first time, by a carboxylic ester moiety. 4-Iodo-1-beta-D-ribofuranosyl-pyrazole-3-carboxylate showed a wide spectrum of antiproliferative activity and a particularly low cytotoxicity against resting PBL, being, unlike the other azole nucleosides, more active than the corresponding primary amide. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00216-8

文献信息

• Design, synthesis and antiproliferative activity of methyl 4-Iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds
  作者：Stefano Manfredini、Rita Bazzanini、Pier Giovanni Baraldi、Daniele Simoni、Silvia Vertuani、Alessandra Pani、Elisabetta Pinna、Franca Scintu、Donatella Lichino、Paolo La Colla

  DOI：10.1016/0960-894x(96)00216-8

  日期：1996.6

  In a SAR study on azole-related nucleosides we have designed some pyrazole-nucleoside analogs characterised, for the first time, by a carboxylic ester moiety. 4-Iodo-1-beta-D-ribofuranosyl-pyrazole-3-carboxylate showed a wide spectrum of antiproliferative activity and a particularly low cytotoxicity against resting PBL, being, unlike the other azole nucleosides, more active than the corresponding primary amide. Copyright (C) 1996 Elsevier Science Ltd
• PARSONS, J. L.;VIZINE, D.;SUMNER, M.;MARATHE, S.;DUBICKI, H.
  作者：PARSONS, J. L.、VIZINE, D.、SUMNER, M.、MARATHE, S.、DUBICKI, H.

  DOI：——

  日期：——
• Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni, Medicinal Chemistry Research, 1996, vol. 6, # 5, p. 293 - 311
  作者：Manfredini, Stefano、Bazzanini, Rita、Baraldi, Pier Giovanni、Simoni, Daniele、Vertuani, Silvia、Pani, Alessandra、Pinna, Elisabetta、Scintu, Franca、De Montis, Antonella、La Colla, Paolo

  DOI：——

  日期：——