4-(2,2-dimethyl-1,3-dioxolan-4-yl)butyl methanesulfonate | 76925-73-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2,2-dimethyl-1,3-dioxolan-4-yl)butyl methanesulfonate
• CAS: 76925-73-0
• 化学式: C₁₀H₂₀O₅S
• 分子量: 252.332
• InChiKey: FBFRWCXRENZNPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(2,2-dimethyl-1,3-dioxolan-4-yl)butyl methanesulfonate 在 叠氮化锂 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以91.2%的产率得到6-azido-1,2-O-isopropylidene-hexane-1,2-diol
  参考文献：
  名称：

  New Indocyanine Derivatives for the Synthesis of Fluorescently Labeled Oligonucleotides

  摘要：

  新型磺化的Cy3和Cy5磷酸酰胺体以及固相支持物被合成。这些构建块用于合成末端或内部标签的寡脱氧核苷酸。对硫氰酸酯标记的寡核苷酸采用了温和的去保护方案。

  DOI：

  10.2174/157017809787003160
• 作为产物：
  描述：

  4-(2,2-dimethyl-1,3-dioxolane-4-yl)-1-butanol 、 甲基磺酰氯 在 吡啶 作用下， 反应 16.0h， 以65.3%的产率得到4-(2,2-dimethyl-1,3-dioxolan-4-yl)butyl methanesulfonate
  参考文献：
  名称：

  New Indocyanine Derivatives for the Synthesis of Fluorescently Labeled Oligonucleotides

  摘要：

  新型磺化的Cy3和Cy5磷酸酰胺体以及固相支持物被合成。这些构建块用于合成末端或内部标签的寡脱氧核苷酸。对硫氰酸酯标记的寡核苷酸采用了温和的去保护方案。

  DOI：

  10.2174/157017809787003160

文献信息

• BIODEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER
  申请人：NOF CORPORATION

  公开号：US20180078651A1

  公开（公告）日：2018-03-22

  A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.

  一种可生物降解的聚乙二醇衍生物，其中聚乙二醇链通过缩醛连接剂连接，该连接剂能够在不同pH环境下精确控制在生物体内的水解速率，并且其分裂速率能够精确控制为低分子量的聚乙二醇链。该可生物降解的聚乙二醇衍生物由式（1）或式（2）所示。
• Liquid-crystalline polyurethanes, compositions of said liquid-crystalline polyurethanes, and a device for optical data storage comprising a liquid-crystalline polyurethane
  申请人：Akzo Nobel N.V.

  公开号：EP0550105A2

  公开（公告）日：1993-07-07

  The invention relates to a liquid-crystalline polyurethane having a side chain comprising a mesogenic group, giving a clear polyurethane which does not isomerise under the influence of light. Such liquid-crystalline polyurethanes are highly suited to be used for optical data storage. The invention further relates to infrared-sensitive liquid-crystalline polyurethanes and liquid-crystalline polyurethane compositions, films containing said liquid-crystalline polyurethanes or polyurethane compositions, and a device for optical data storage containing said liquid-crystalline polyurethanes or polyurethane compositions.

  本发明涉及一种液晶聚氨酯，其侧链包含一个介原基，从而产生一种在光照下不发生异构化的透明聚氨酯。这种液晶聚氨酯非常适合用于光学数据存储。本发明还涉及对红外线敏感的液晶聚氨酯和液晶聚氨酯组合物、含有上述液晶聚氨酯或聚氨酯组合物的薄膜，以及含有上述液晶聚氨酯或聚氨酯组合物的光学数据存储设备。
• Antibody-drug conjugate having cyclic benzylidene acetal linker
  申请人：NOF CORPORATION

  公开号：US10377837B2

  公开（公告）日：2019-08-13

  An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Z1 and Z2 are each independently a selected divalent spacer:

  一种抗体-药物共轭物，具有由式（1）或式（2）表示的环状亚苄基缩醛连接体，其中 Y 是抗体；D 是药物；R1 和 R6 各自独立地是氢原子或烃基；R2、R3、R4 和 R5 各自独立地是一个取电子或供电子的取代基或一个氢原子；s 是 1 或 2，t 是 0 或 1，s+t 是 1 或 2；w 是 1 至 20 的整数；以及 Z1 和 Z2 各自独立地是一个选定的二价间隔物：
• Lipid derivative in which hydrophilic polymer is bound through cyclic benzylidene acetal linker
  申请人：NOF CORPORATION

  公开号：US10626217B2

  公开（公告）日：2020-04-21

  A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker, and which can accurately control a hydrolysis rate in the weakly acidic environment of a living body to detach the hydrophilic polymer from a lipid membrane structure. The lipid derivative is represented by formula (1): wherein, R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; R7 is a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; and Z1 and Z2 are each independently a selected divalent spacer.

  一种脂质衍生物，其中的亲水性聚合物通过环状亚苄基乙缩醛连接体结合，并能在生物体的弱酸性环境中精确控制水解速度，使亲水性聚合物从脂质膜结构中脱离。脂质衍生物由式（1）表示： 其中，R1 和 R6 各自独立地为氢原子或烃基；R2、R3、R4 和 R5 各自独立地为取电子或供电子取代基或氢原子；R7 是具有 8 至 24 个碳原子的烃基、具有 8 至 24 个碳原子的酰基、胆固醇衍生物、甘油酯、磷脂或鞘磷脂；P 是亲水性聚合物；s 是 1 或 2，t 是 0 或 1，s+t 是 1 或 2；以及 Z1 和 Z2 各自独立地是选定的二价间隔物。
• Biodegradable hydrogel having cyclic benzylidene acetal structure
  申请人：NOF CORPORATION

  公开号：US11041052B2

  公开（公告）日：2021-06-22

  A biodegradable hydrogel having an acetal structure whose hydrolysis rate under different pH environments in the living body can be accurately controlled. The hydrogel is obtained by crosslinking a polyalkylene glycol derivative having a cyclic benzylidene acetal structure represented by formula (1) shown below with a crosslinking agent: where R1 and R6; R2, R3, R4 and R5; s; t; s+t; P1; Z1 and Z2; W1 and X1 are as defined herein.

  一种具有缩醛结构的可生物降解水凝胶，其在活体内不同 pH 值环境下的水解速率可精确控制。这种水凝胶是由具有下式（1）所示环状亚苄基缩醛结构的聚亚烷基二醇衍生物与交联剂交联而成： 其中 R1 和 R6；R2、R3、R4 和 R5；s；t；s+t；P1；Z1 和 Z2；W1 和 X1 如本文所定义。