2-fluoro-3-methylbut-2-enylammonium chloride

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 2-fluoro-3-methylbut-2-enylammonium chloride
• 英文别名: 2-fluoro-3-methylbut-2-enylamine hydrochloride；2-fluoro-3-methylbut-2-en-1-amine;hydrochloride
• 化学式: C₅H₁₀FN*ClH
• mdl: MFCD19212495
• 分子量: 139.6
• InChiKey: QGLYQDKZKVXCCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.51
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-氯嘌呤 、 2-fluoro-3-methylbut-2-enylammonium chloride 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以76%的产率得到6-(2-fluoro-3-methylbut-2-enylamino)purine
  参考文献：
  名称：

  Synthesis and Cytokinin Activity of Two Fluoro Derivatives of N⁶-Isopentenyladenine

  摘要：

  Two derivatives of N-6-isopentenyladenine, 3 and 4, bearing either a vinylic fluorine atom or a trifluoromethyl group, were easily synthesized from known fluorinated precursors. Both derivatives 3 and 4 were found to be more active, as cytokinins, than the parent compounds zeatin (1) and N-6-isopentenyladenine (2).

  DOI：

  10.1021/jf9501148
• 作为产物：
  描述：

  2-氟-3-甲基丁-2-烯酸乙酯 在 三(2-氯乙基)胺 、 偶氮二甲酸二异丙酯 、 二异丁基氢化铝 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 苯 为溶剂， 反应 6.0h， 生成 2-fluoro-3-methylbut-2-enylammonium chloride
  参考文献：
  名称：

  Synthesis and Cytokinin Activity of Two Fluoro Derivatives of N⁶-Isopentenyladenine

  摘要：

  Two derivatives of N-6-isopentenyladenine, 3 and 4, bearing either a vinylic fluorine atom or a trifluoromethyl group, were easily synthesized from known fluorinated precursors. Both derivatives 3 and 4 were found to be more active, as cytokinins, than the parent compounds zeatin (1) and N-6-isopentenyladenine (2).

  DOI：

  10.1021/jf9501148

文献信息

• [EN] PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS<br/>[FR] DÉRIVÉS PYRROLIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA VOIE DU COMPLÉMENT
  申请人：NOVARTIS AG

  公开号：WO2014002052A1

  公开（公告）日：2014-01-03

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D inhibitor for the treatment of ophthalmic diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种化合物（I）的方法，用于制造本发明的化合物，并将其作为因子D抑制剂用于治疗眼科疾病。本发明还提供了一种药理活性剂的组合和一种药物组合物。
• PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS
  申请人：FLOHR Stefanie

  公开号：US20150322060A1

  公开（公告）日：2015-11-12

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D inhibitor for the treatment of ophthalmic diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物(I)的公式，以及制备该化合物的方法，并将其用作因子D抑制剂治疗眼科疾病的治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。
• US9464081B2
  申请人：——

  公开号：US9464081B2

  公开（公告）日：2016-10-11
• Synthesis and Cytokinin Activity of Two Fluoro Derivatives of <i>N</i>⁶-Isopentenyladenine
  作者：Denis Clemenceau、Jack Cousseau、Valérie Martin、Huguette Molines、Claude Wakselman、René Mornet、Fabien Nogue、Michel Laloue

  DOI：10.1021/jf9501148

  日期：1996.1.1

  Two derivatives of N-6-isopentenyladenine, 3 and 4, bearing either a vinylic fluorine atom or a trifluoromethyl group, were easily synthesized from known fluorinated precursors. Both derivatives 3 and 4 were found to be more active, as cytokinins, than the parent compounds zeatin (1) and N-6-isopentenyladenine (2).