特比萘芬杂质 | 27843-27-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: 特比萘芬杂质
• 英文名称: 2-chloro-3,3-dimethyl-1-butene
• 英文别名: 2-Chlor-3,3-dimethyl-1-buten；2-Chlor-3,3-dimethyl-but-1-en；2-chloro-3,3-dimethylbut-1-ene
• CAS: 27843-27-2
• 化学式: C₆H₁₁Cl
• 分子量: 118.606
• InChiKey: MVMWZSSWTKRGLB-UHFFFAOYSA-N

物化性质

• 沸点：
  95-95 °C(Press: 730 Torr)
• 密度：
  0.8843 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  特比萘芬杂质 在 水 、 氢溴酸 、 potassium acetate 、 sodium 作用下， 生成 3,3-二甲基-1-丁酸
  参考文献：
  名称：

  Delacre, Chemisches Zentralblatt, 1906, vol. 77, # I, p. 1233

  摘要：

  DOI：
• 作为产物：
  描述：

  频哪酮 在 光气 、 tetrabutylphosphanium diethyl phosphate 、 三乙胺 、 三甲氧基磷 作用下， 以 2-甲基四氢呋喃 为溶剂， 反应 22.0h， 以91%的产率得到特比萘芬杂质
  参考文献：
  名称：

  一种利用光气制备氯乙烯类化合物的方法

  摘要：

  本发明涉及一种利用光气制备氯乙烯类化合物的方法，该方法包括，向含有式(I)所示的季鏻盐离子液体、有机碱、式(II)所示的助剂亚磷酸三烃基酯和式(III)所示的酮类化合物的有机溶剂溶液中，滴加光气的有机溶剂溶液进行反应，得到包含式(IV)所示的氯乙烯类化合物的反应产物。根据本发明，采用包含季鏻盐离子液体的有机溶剂为反应的溶剂，可以促进反应更高效地进行，反应体系中仅需要使用催化量的由式(II)表示的助剂亚磷酸三烃基酯，反应完成后可以通过萃取使季鏻盐离子液体可以实现回收套用。

  公开号：

  CN111233618B

文献信息

• Photochromic Indeno-Fused Ring Pyran Compounds
  申请人：Transitions Optical, Inc.

  公开号：US20150141661A1

  公开（公告）日：2015-05-21

  The present invention relates to photochromic indeno-fused ring pyran compounds represented by the following Formula (I-A): The present invention also relates to photochromic dichroic compounds, such as represented by Formula (I-A), in which (i) Z 2 is a group N—R 13 in which R 13 is a group L, and (ii) optionally at least one R 1 independently for each n is selected from a group L, in which the group L independently in each case is a lengthening group that provides the photochromic compound with dichroic properties, in accordance with some embodiments. The present invention also relates to photochromic articles, such as photochromic ophthalmic articles, that include one or more photochromic compounds according to the present invention, such as represented by Formula (I-A).

  本发明涉及由以下式（I-A）表示的光致变色吲哚融合环吡喃化合物。本发明还涉及光致二向色化合物，例如由式（I-A）表示，其中（i）Z2是一个N—R13基团，其中R13是一个L基团，以及（ii）对于每个n，可选地至少选择一个R1，每种情况下独立选择自L基团，其中每种情况下L基团是一个提供光致化合物二向色性能的延伸基团，符合某些实施例。本发明还涉及光致物品，例如光致眼科物品，包括根据本发明的一个或多个光致化合物，例如由式（I-A）表示。
• PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS
  申请人：Chopra Anu

  公开号：US20120053341A1

  公开（公告）日：2012-03-01

  The present invention relates to photochromic materials that include certain indeno-fused naphthopyrans. The indeno-fused naphthopyrans have an amino group (e.g., a piperidino or morpholino group) bonded to the 6-position and an optional halo group (e.g., fluoro) bonded to the 11-position thereof. The photochromic materials of the present invention may have a closed-form electromagnetic radiation absorption spectrum that is shifted to longer wavelengths (e.g., wavelengths of greater than 390 nm), relative to comparable photochromic materials. The present invention also relates to optical elements, such as eyeglasses, that include the photochromic materials of the present invention.

  本发明涉及包括某些吲哚并螺[3,3,3]己喹喙的光致变色材料。这些吲哚并螺[3,3,3]己喹喙在6位与氨基团（例如哌啶基或吗啉基）键合，并且在11位可能与卤素基团（例如氟基）键合。本发明的光致变色材料可能具有闭合形式的电磁辐射吸收光谱，其相对于类似的光致变色材料向更长波长（例如大于390纳米的波长）移动。本发明还涉及包括本发明的光致变色材料的光学元件，例如眼镜。
• [EN] 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF<br/>[FR] 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：SAMUMED LLC

  公开号：WO2017023980A1

  公开（公告）日：2017-02-09

  6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

  披露了用于治疗各种疾病和病理的6-氮杂吲唑化合物。更具体地，本公开涉及使用6-氮杂吲唑化合物或其类似物，治疗由Wnt途径信号激活所特征的疾病（例如癌症、异常细胞增殖、血管生成、纤维化疾病、骨骼或软骨疾病和骨关节炎），调节由Wnt途径信号介导的细胞事件，以及由于Wnt途径和/或一个或多个Wnt信号组分的突变或失调而导致的遗传疾病和神经病理条件/障碍/疾病。还提供了治疗与Wnt相关疾病状态的方法。
• METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS
  申请人：Chopra Anu

  公开号：US20120157696A1

  公开（公告）日：2012-06-21

  The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, which can be represented by the following general Formula V, With Formula V, m is from 0 to 4, and R 1 for each m, R g and R h can each be independently selected from, for example, hydrogen and hydrocarbyl. The present invention also relates to a method of making an indeno-fused naphthopyran that involves an indanone acid intermediate synthetic route.

  本发明涉及一种制备茚并萘酚材料的方法，其中在某些实施例中，涉及形成一种茚酮酸中间体，该中间体可以用以下一般式V表示，式中，m取值范围为0至4，对于每个m，Rg和Rh可以分别独立地选择为氢和烃基。本发明还涉及一种制备茚并萘吡喃的方法，该方法涉及一种茚酮酸中间体的合成路线。
• Thermally initiated reactions of (z)-epoxyhexenynes a facile preparation of 3,4-annulated furans
  作者：Wolfgang Eberbach、Joachim Roser

  DOI：10.1016/s0040-4020(01)90602-7

  日期：1986.1

  An efficient and general access to 3,4-annulated 2-vinylfurans (type II) is provided by the thermally induced ring transformation of epoxyhexenynes (I). Depending on the substitution pattern the reactions proceed either by heating in solution () or under short-time thermolysis conditions (). The results are consistent with a multistep mechanism involving 1-oxacyclohepta-3,4,6-trienes as central intermediates

  通过环氧己烯（I）的热诱导环转化，可以有效而普遍地获得3,4-环氧基2-乙烯基呋喃（II型）。根据取代方式，反应可通过在溶液中加热（）或在短时间热解条件下（）进行。结果与涉及1-氧杂环庚-3,4,6-三烯作为中心中间体的多步机理一致。