2-(4'-chlorophenyl)-N-cyclohexyl-2-[2-oxo-4-phenyl-3-tosyl-2H-quinolin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4'-chlorophenyl)-N-cyclohexyl-2-[2-oxo-4-phenyl-3-tosyl-2H-quinolin-1-yl]acetamide
• 英文别名: 2-(4-chlorophenyl)-N-cyclohexyl-2-[3-(4-methylphenyl)sulfonyl-2-oxo-4-phenylquinolin-1-yl]acetamide
• 化学式: C₃₆H₃₃ClN₂O₄S
• 分子量: 625.188
• InChiKey: CIZQAQSIQLELRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  91.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲苯磺酰乙酸 在 sodium hydride 作用下， 以 甲醇 为溶剂， 反应 52.0h， 生成 2-(4'-chlorophenyl)-N-cyclohexyl-2-[2-oxo-4-phenyl-3-tosyl-2H-quinolin-1-yl]acetamide
  参考文献：
  名称：

  One-pot synthesis of quinolin-2-(1 H )-ones via tandem Ugi–Knoevenagel condensations

  摘要：

  A new application of the Ugi reaction in the synthesis of heterocyclic compounds is described. Substituted quinolin-2- (1H)-ones are formed in one-pot sequential Ugi four-component condensation and intramolecular Knoevenagel cyclization between o-acylanilines. aldehydes. malonic or tosylacetic acids and cyclohexyl isocyanide. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.03.184

文献信息

• One-pot synthesis of quinolin-2-(1 H )-ones via tandem Ugi–Knoevenagel condensations
  作者：Stefano Marcaccini、Roberto Pepino、M.Cruz Pozo、Sara Basurto、Marı́a Garcı́a-Valverde、Tomás Torroba

  DOI：10.1016/j.tetlet.2004.03.184

  日期：2004.5

  A new application of the Ugi reaction in the synthesis of heterocyclic compounds is described. Substituted quinolin-2- (1H)-ones are formed in one-pot sequential Ugi four-component condensation and intramolecular Knoevenagel cyclization between o-acylanilines. aldehydes. malonic or tosylacetic acids and cyclohexyl isocyanide. (C) 2004 Elsevier Ltd. All rights reserved.