3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene
• 英文别名: N-methyl-N-[(5-methyl-1,2-oxazol-3-yl)diazenyl]methanamine
• 化学式: C₆H₁₀N₄O
• 分子量: 154.172
• InChiKey: ITMHRTLMHQAZNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene 在 硫酸 、 硝酸 作用下， 反应 1.0h， 以35%的产率得到3,3-dimethyl-1-(5-methyl-4-nitroisoxazol-3-yl)triazene
  参考文献：
  名称：

  Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene

  摘要：

  The synthesis of some 3,3-dialkyl-1-(isoxazol-3-yl)triazenes is reported, together with preliminary biological tests on 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene 3a. This compound exerts a selective antimetastatic action in mice bearing Lewis lung carcinoma, reducing the weight but not the number of metastases. Some unfavorable properties in the toxicological profile of 3a have discouraged further investigation of this class of compounds.

  DOI：

  10.1016/0223-5234(96)85884-3
• 作为产物：
  描述：

  3-氨基-5-甲基异恶唑 、 二甲胺 在 盐酸 、 sodium nitrite 作用下， 生成 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene
  参考文献：
  名称：

  Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene

  摘要：

  The synthesis of some 3,3-dialkyl-1-(isoxazol-3-yl)triazenes is reported, together with preliminary biological tests on 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene 3a. This compound exerts a selective antimetastatic action in mice bearing Lewis lung carcinoma, reducing the weight but not the number of metastases. Some unfavorable properties in the toxicological profile of 3a have discouraged further investigation of this class of compounds.

  DOI：

  10.1016/0223-5234(96)85884-3

文献信息

• Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene
  作者：A Tontini、G Diamantini、C Balsamini、G Tarzia、L Perissin、V Rapozzi

  DOI：10.1016/0223-5234(96)85884-3

  日期：1996.1

  The synthesis of some 3,3-dialkyl-1-(isoxazol-3-yl)triazenes is reported, together with preliminary biological tests on 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene 3a. This compound exerts a selective antimetastatic action in mice bearing Lewis lung carcinoma, reducing the weight but not the number of metastases. Some unfavorable properties in the toxicological profile of 3a have discouraged further investigation of this class of compounds.