(3,5-bis((2-ethylhexyl)oxy)phenyl)methanol | 863591-45-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3,5-bis((2-ethylhexyl)oxy)phenyl)methanol
• 英文别名: 3,5-di(2-ethylhexyloxy)phenyl methanol；3,5-bis(2-ethylhexyloxy)benzyl alcohol；[3,5-Bis(2-ethylhexoxy)phenyl]methanol
• CAS: 863591-45-1
• 化学式: C₂₃H₄₀O₃
• 分子量: 364.569
• InChiKey: VTNPDSWTOPZZJT-UHFFFAOYSA-N

物化性质

• 沸点：
  479.3±30.0 °C(Predicted)
• 密度：
  0.951±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3,5-bis((2-ethylhexyl)oxy)phenyl)methanol 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 生成 2-(3,5-bis((2-ethylhexyl)oxy)benzyl)isoindoline-1,3-dione
  参考文献：
  名称：

  用于 mRNA 的单组分多功能序列定义的可电离两亲性 Janus 树状聚合物递送系统

  摘要：

  核酸的有效病毒或非病毒递送是基因纳米医学的关键步骤。病毒和合成载体都已成功用于基因传递，最近的例子是基于 DNA、腺病毒和 mRNA 的 Covid-19 疫苗。病毒载体可以针对特定目标且非常有效，但也可以介导严重的免疫反应、细胞毒性和突变。四组分脂质纳米颗粒 (LNP) 包含可电离脂质、磷脂、用于机械性能的胆固醇和用于稳定性的 PEG 缀合脂质，代表了当前领先的 mRNA 非病毒载体。然而，中性可电离脂质在 LNP 核心中分离为液滴、“PEG 困境”以及仅在极低温度下的稳定性限制了它们的效率。这里，我们报告了一种用于 mRNA 的单组分多功能可电离两亲性两亲树枝状聚合物 (IAJD) 递送系统的开发，该系统在以序列定义的排列组织的低浓度可电离胺下表现出高活性。包含 54 个序列定义的 IAJD 的六个文库通过加速模块化正交方法合成，并通过简单的注射方法而不是通常用于 LNP 的复杂微流体技术与

  DOI：

  10.1021/jacs.1c05813
• 作为产物：
  描述：

  3,5-二羟基苯甲酸 在 lithium aluminium tetrahydride 、 硫酸 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 (3,5-bis((2-ethylhexyl)oxy)phenyl)methanol
  参考文献：
  名称：

  用于 mRNA 的单组分多功能序列定义的可电离两亲性 Janus 树状聚合物递送系统

  摘要：

  核酸的有效病毒或非病毒递送是基因纳米医学的关键步骤。病毒和合成载体都已成功用于基因传递，最近的例子是基于 DNA、腺病毒和 mRNA 的 Covid-19 疫苗。病毒载体可以针对特定目标且非常有效，但也可以介导严重的免疫反应、细胞毒性和突变。四组分脂质纳米颗粒 (LNP) 包含可电离脂质、磷脂、用于机械性能的胆固醇和用于稳定性的 PEG 缀合脂质，代表了当前领先的 mRNA 非病毒载体。然而，中性可电离脂质在 LNP 核心中分离为液滴、“PEG 困境”以及仅在极低温度下的稳定性限制了它们的效率。这里，我们报告了一种用于 mRNA 的单组分多功能可电离两亲性两亲树枝状聚合物 (IAJD) 递送系统的开发，该系统在以序列定义的排列组织的低浓度可电离胺下表现出高活性。包含 54 个序列定义的 IAJD 的六个文库通过加速模块化正交方法合成，并通过简单的注射方法而不是通常用于 LNP 的复杂微流体技术与

  DOI：

  10.1021/jacs.1c05813

文献信息

• Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
  作者：Dapeng Zhang、Elena N. Atochina-Vasserman、Devendra S. Maurya、Matthew Liu、Qi Xiao、Juncheng Lu、George Lauri、Nathan Ona、Erin K. Reagan、Houping Ni、Drew Weissman、Virgil Percec

  DOI：10.1021/jacs.1c09585

  日期：2021.11.3

  consisting of ionizable lipids, phospholipids, cholesterol, and a PEG-conjugated lipid, assembled by microfluidic or T-tube technology, have been extraordinarily successful for delivery of mRNA to provide Covid-19 vaccines. Recently, we reported a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) synthetic delivery system for mRNA relying on amphiphilic Janus dendrimers

  用病毒和合成载体靶向和有效地递送核酸是基因纳米医学的关键步骤。由可电离脂质、磷脂、胆固醇和 PEG 结合脂质组成的四组分脂质纳米颗粒合成递送系统，通过微流体或 T 管技术组装，在递送 mRNA 以提供 Covid-19 疫苗方面非常成功。最近，我们报道了一种单组分多功能序列定义的可电离两亲性 Janus 树枝状聚合物 (IAJD) 合成递送系统，该系统依赖于我们实验室开发的两亲性 Janus 树枝状聚合物和糖树状聚合物。两亲性 Janus 树枝状聚合物由与疏水树枝共轭的功能性亲水树枝组成。IAJDs 与 mRNA 共组装成树枝状大分子纳米颗粒 (DNPs) 是通过在醋酸盐缓冲液中简单注射而不是通过微流体装置进行的，并提供了一个非常有效的系统来将 mRNA 输送到肺部。在这里，我们报告了 IAJD 中树突的大部分亲水性片段被替换，仅保留其可电离的胺，同时将其互连基团从酰胺变为酯的疏水树突。由此产生的
• Synthesis and nonlinear optical properties of branched pyrroline chromophores
  作者：Jialei Liu、Wenjun Hou、Shuwen Feng、Ling Qiu、Xinhou Liu、Zhen Zhen

  DOI：10.1002/poc.1772

  日期：2011.6

  New tricyanopyrroline (TCP) chromophores with rigid–flexible dendron were prepared for second‐order nonlinear optical (NLO) application. The chromophores were fully characterized using ultraviolet‐visible spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrometry. Thermal gravimetric analysis (TGA) revealed that the chromophores had excellent thermal stability. Large λmax and high

  制备了具有刚性-柔性树突的新型三氰基吡咯啉（TCP）生色团，用于二阶非线性光学（NLO）应用。使用紫外可见光谱，核磁共振光谱和质谱对发色团进行了充分表征。热重分析（TGA）表明，生色团具有出色的热稳定性。大λ最大和高铬合物的影响表明，发色团具有较大的二阶非线性光学。电光系数（[R 33）在掺杂的发色团的聚测定（双酚A碳酸酯）在1310nm，最高基波波长膜γ 33实现是217 PMV -1。版权所有©2010 John Wiley＆Sons，Ltd.
• The synthesis of symmetric and asymmetric perylene derivatives and their optical properties
  作者：Sang Hyun Oh、Bong Gun Kim、Sun Ju Yun、Muchchintala Maheswara、Ketack Kim、Jung Yun Do

  DOI：10.1016/j.dyepig.2009.10.001

  日期：2010.4

  Symmetric bisimidazole and asymmetric imide-imidazole derivatives having a perylene structure were synthesized. Long, hyperbranched alkyl groups. attached to the benzimidazole moeity, enhanced the solubility of the imidazole derivatives. Soluble asymmetric imide-imidazoles were prepared using 1,2-diaminophenyls which contained methoxy. nitro and ester groups. The effects of both electron-withdrawing and donating groups were examined optically and electronically using both absorption and emission spectroscopy Photoluminescence spectroscopy revealed that the various perylene derivatives displayed varying quantum yield: frontier orbital energy levels were determined using cyclic voltammetric analysis. The asymmetric imide-imidazole displayed the transient. electronic and optical properties of symmetric bisimide and symmetric bisimidazole perylene derivatives Nitro derivation reduced the LUMO energy level of the asymmetric perylene by 0.05 eV while methoxy derivation increased it by 0.07 ev, in comparison with that of the unsubstituted, asymmetric perylene. Either bathochromic or hypsochromic spectral shifts of the asymmetric imidazoles were observed in solid film. depending oil electronic substituent. (C) 2009 Elsevier Ltd All rights reserved
• A new approach toward light-harvesting reverse micelles from donor–acceptor miscible blends
  作者：Masaki Takahashi、Natsuko Nishizawa、Shuhei Ohno、Masahiro Kakita、Norifumi Fujita、Mitsuji Yamashita、Tetsuya Sengoku、Hidemi Yoda

  DOI：10.1016/j.tet.2009.01.089

  日期：2009.3

  In the present paper, we report a new approach toward light-harvesting reverse micellar systems from molecular blends Of anthracene and perylene building blocks. The self-assembly initiated by protonation of the molecular blends gave rise to the mixed reverse micelles, in which intermolecular energy transfer from the anthracene to the perylene chromophores was observed. The atomic force microscope (AFM) studies on the reverse micelles prepared from the donor and acceptor blends at a range of the feed ratios showed a number of nanoscale-sized spherical objects homogeneously dispersed on the highly oriented pyrolytic graphite (HOPG) substrate. The critical micelle concentration (cmc) Values of the reversed micelles at the donor: acceptor ratios of 100:0, 50:50, and 0:100 were estimated to be 7, 3, and 10 PM by fluorescence batch titrations, respectively, indicating that the cmc values should be almost equivalent regardless of the Constitution of each chromophoric component. Attempt to generate the mixed reverse micelles through pairwise mixing of the donor- and acceptor-based reverse micelles resulted in spectral behaviors identical with those obtained by the self-assembly employing the donor-acceptor blends. This suggests that these two reverse micelles undergo thermodynamic exchange of the surfactant molecules to afford the mixed reverse micelles when mixing the two discrete reverse micellar systems. (c) 2009 Elsevier Ltd. All rights reserved.
• [EN] ONE-COMPONENT DELIVERY SYSTEM FOR NUCLEIC ACIDS<br/>[FR] SYSTÈME D'ADMINISTRATION À COMPOSANT UNIQUE POUR ACIDES NUCLÉIQUES
  申请人：[en]THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：WO2022251191A1

  公开（公告）日：2022-12-01

  The invention relates to amphiphilic Janus dendrimers which may form nanoparticles. The invention also relates to methods of inducing an adaptive immune response in a subject comprising administering to the subject an effective amount of a composition comprising at least one nucleoside-modified RNA encoding at least one antigen and at least one amphiphilic Janus dendrimer and to methods of delivering an agent to a subject in need thereof, said method comprising the step of delivering to the subject a composition comprising an agent encapsulated by a nanoparticle.