2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl 2-(3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)propanoate | 1432024-07-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl 2-(3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)propanoate
• 英文别名: 2-Oxo-2-[4-(trifluoromethyl)phenyl]ethyl 2-(3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)propanoate；[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl] 2-[3-(phenylmethoxycarbonylamino)oxetan-3-yl]propanoate
• CAS: 1432024-07-1
• 化学式: C₂₃H₂₂F₃NO₆
• 分子量: 465.426
• InChiKey: DZUBFPMJHANQIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  在 水 、 碳酸氢钠 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 、 乙酸乙酯 为溶剂， 反应 20.0h， 生成 2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl 2-(3-{[(benzyloxy)carbonyl]amino}oxetan-3-yl)propanoate
  参考文献：
  名称：

  [EN] (4-PHENYLIMIDAZOL-2-YL) ETHYLAMINE DERIVATIVES USEFUL AS SODIUM CHANNEL MODULATORS
  [FR] COMPOSÉS CHIMIQUES

  摘要：

  公开号：

  WO2013061205A8

文献信息

• (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
  申请人：Pfizer Limited

  公开号：US09079878B2

  公开（公告）日：2015-07-14

  The present invention is directed to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole NaV1.8 modulators of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. NaV1.8 modulators are useful in the treatment of a wide range of disorders, particularly pain.

  本发明涉及咪唑衍生物，其在医学上的应用，包含它们的组成物，制备过程以及用于这种过程的中间体。更具体地，本发明涉及一种新的咪唑NaV1.8调节剂，其化学式为(I)，或其药学上可接受的盐，其中R1，R2，R3，R4和R5如描述中所定义。NaV1.8调节剂在治疗广泛的疾病中特别是疼痛方面有用。
• (4-Phenylimidazol-2-yl) Ethylamine Derivatives Useful As Sodium Channel Modulators
  申请人：Pfizer Limited

  公开号：US20140296313A1

  公开（公告）日：2014-10-02

  The present invention is directed to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole Na V 1.8 modulators of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description. Na V 1.8 modulators useful in the treatment of a wide range of disorders, particularly pain.

  本发明涉及咪唑衍生物，其在医学上的应用，包含它们的组合物，制备它们的方法以及用于这些方法的中间体。更具体地，本发明涉及一种新的咪唑NaV1.8调节剂，其化学式为(I)或其药学上可接受的盐，其中R1、R2、R3、R4和R5如描述中所定义。NaV1.8调节剂在治疗各种疾病，特别是疼痛方面具有用途。
• (4-PHENYLIMIDAZOL-2-YL) ETHYLAMINE DERIVATIVES USEFUL AS SODIUM CHANNEL MODULATORS
  申请人：Pfizer Limited

  公开号：EP2771335A2

  公开（公告）日：2014-09-03
• US9079878B2
  申请人：——

  公开号：US9079878B2

  公开（公告）日：2015-07-14
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：PFIZER LTD

  公开号：WO2013061205A2

  公开（公告）日：2013-05-02

  The invention relates to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole Nav1.8 modulators of formula ( I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.