3-chloro-1-(4-chloro-3,5-dimethylphenyl)propan-1-one | 1062646-58-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-chloro-1-(4-chloro-3,5-dimethylphenyl)propan-1-one
• 英文别名: 3-Chloro-1-(4-chloro-3,5-dimethylphenyl)propan-1-one
• CAS: 1062646-58-5
• 化学式: C₁₁H₁₂Cl₂O
• 分子量: 231.122
• InChiKey: IERWDVYKGBLBCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯-1,3-二甲苯 、 3-氯丙酰氯 在 三氯化铝 作用下， 以 二硫化碳 为溶剂， 反应 0.5h， 生成 3-chloro-1-(3-chloro-2,4-dimethylphenyl)propan-1-one 、 3-chloro-1-(4-chloro-3,5-dimethylphenyl)propan-1-one
  参考文献：
  名称：

  New 1-indanone thiosemicarbazone derivatives active against BVDV

  摘要：

  Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI = 80.29) than that of ribavirin (SI = 11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.10.023

文献信息

• New 1-indanone thiosemicarbazone derivatives active against BVDV
  作者：Liliana M. Finkielsztein、Eliana F. Castro、Lucas E. Fabián、Graciela Y. Moltrasio、Rodolfo H. Campos、Lucía V. Cavallaro、Albertina G. Moglioni

  DOI：10.1016/j.ejmech.2007.10.023

  日期：2008.8

  Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI = 80.29) than that of ribavirin (SI = 11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus. (c) 2007 Elsevier Masson SAS. All rights reserved.