(R)-(-)-2-氯-1-丙醇 | 37493-14-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 中文名称: (R)-(-)-2-氯-1-丙醇
• 英文名称: (R)-(-)-2-chloro-propan-1-ol
• 英文别名: (R)-2-chloro-propyl alcohol；(2R)-2-chloro-1-propanol；R(-)-2-Chloro-1-propanol；(R)-2-chloropropan-1-ol；R(-)-2-chloropropanol；(R)-chloropropanol；(R)-(-)-2-Chloropropan-1-ol；(2R)-2-chloropropan-1-ol
• CAS: 37493-14-4
• 化学式: C₃H₇ClO
• 分子量: 94.541
• InChiKey: VZIQXGLTRZLBEX-GSVOUGTGSA-N

物化性质

• 比旋光度：
  -17 º (c=neat)
• 沸点：
  130 °C
• 密度：
  1.09
• 闪点：
  51 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R20/21/22,R10,R36/37/38
• 危险品运输编号：
  UN 2611
• WGK Germany：
  1
• RTECS号：
  RA8225000
• 海关编码：
  29141990
• 安全说明：
  S16,S26,S27,S36/37/39
• 包装等级：
  II
• 危险类别：
  3
• 危险性防范说明：
  P210,P280,P305+P351+P338
• 危险性描述：
  H225,H302+H312+H332,H319

SDS

Name:	(R)-(-)-2-Chloropropan-1-ol 96% Material Safety Data Sheet
Synonym:	None known
CAS:	37493-14-4

Section 1 - Chemical Product MSDS Name:(R)-(-)-2-Chloropropan-1-ol 96% Material Safety Data Sheet
Synonym:None known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
37493-14-4	(R)-(-)-2-Chloropropan-1-ol	98	unlisted

Hazard Symbols: XN
Risk Phrases: 10 20/21/22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Harmful by inhalation, in contact with skin and if swallowed.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
May cause irritation and dermatitis. May cause cyanosis of the extremities.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Ingestion of large amounts may cause CNS depression.
Inhalation:
The toxicological properties of this substance have not been fully investigated. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause burning sensation in the chest.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 37493-14-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: Clear - clear, colorless
Odor: alcohol-like
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 124 - 128 deg C @ 760.00mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 44 deg C ( 111.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density: 1.0720g/cm3
Molecular Formula: C3H7ClO
Molecular Weight: 94.53

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 37493-14-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(R)-(-)-2-Chloropropan-1-ol - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: PROPYLENE CHLOROHYDRIN
Hazard Class: 6.1 (3)
UN Number: 2611
Packing Group: II
IMO
Shipping Name: PROPYLENE CHLOROHYDRIN
Hazard Class: 6.1 (3)
UN Number: 2611
Packing Group: II
RID/ADR
Shipping Name: PROPYLENE CHLOROHYDRIN
Hazard Class: 6.1
UN Number: 2611
Packing group: II

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 10 Flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 23 Do not inhale gas/fumes/vapour/spray.
S 28A After contact with skin, wash immediately with
plenty of water.
S 33 Take precautionary measures against static
discharges.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 37493-14-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 37493-14-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 37493-14-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

(a)-(-)-(−)-2-氯-1-丙醇用作研究用化合物。

反应信息

• 作为反应物：
  描述：

  对硝基肉桂酸 、 (R)-(-)-2-氯-1-丙醇 生成 p-Aminozimtsaeure-R(-)-2-chlorpropylester
  参考文献：
  名称：

  Keller,P. et al., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1976, vol. 282, p. 639 - 641

  摘要：

  DOI：
• 作为产物：
  描述：

  L(-)-乳酸乙酯 生成 (R)-(-)-2-氯-1-丙醇
  参考文献：
  名称：

  Keller,P. et al., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1976, vol. 282, p. 639 - 641

  摘要：

  DOI：

文献信息

• ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20190322658A1

  公开（公告）日：2019-10-24

  The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

  本发明提供了式I′的化合物，或其药学上可接受的盐，以及用于治疗细胞增殖性疾病（例如癌症）的药物组合物和使用方法。
• Oxidation of olefins by palladium(II)
  作者：Arab El-Qisairi、Patrick M Henry

  DOI：10.1016/s0022-328x(00)00070-x

  日期：2000.5

  Previous studies showed that oxidation of α-olefins with monometallic catalysts containing chiral diphosphines and diamines gave chlorohydrins with poor to good enantioselectivites (28–82% ee). The present studies demonstrate that bimetallic catalysts containing a β-triketone and bridging chiral diphosphine and diamines are excellent catalysts for this reaction giving enantioselectivites considerably

  先前的研究表明，用含有手性二膦和二胺的单金属催化剂氧化α-烯烃会得到氯醇，其对映体选择性差至良好（28-82％ee）。本研究表明，含有β-三酮和桥联手性二膦和二胺的双金属催化剂是该反应的极好催化剂，其对映体选择性比单金属催化剂高得多。对于大多数测试的烯烃，对映选择性大于50％。最高的光学纯度是丙烯的94％ee和烯丙基苯基醚的93％ee。这种不对称合成的一个有用的特征是它是净空气氧化的事实。
• Direct Organocatalytic Asymmetric α-Chlorination of Aldehydes
  作者：Nis Halland、Alan Braunton、Stephan Bachmann、Mauro Marigo、Karl Anker Jørgensen

  DOI：10.1021/ja049231m

  日期：2004.4.1

  The direct organocatalytic enantioselective α-chlorination of aldehydes has been developed. The reaction proceeds for a series of different aldehydes with NCS as the chlorine source using easily available catalysts such as l-proline amide and (2R,5R)-diphenylpyrrolidine. The α-chloro aldehydes are obtained in up to 99% yield and up to 95% ee. The synthetic utility of the enantioselective α-chlorination

  已经开发了醛的直接有机催化对映选择性 α-氯化。使用容易获得的催化剂如 l-脯氨酸酰胺和 (2R,5R)-二苯基吡咯烷，以 NCS 作为氯源，对一系列不同的醛进行反应。α-氯醛的产率高达 99%，ee 高达 95%。通过标准还原将 α-氯醛转化为相应的 α-氯醇（>90% 产率）并进一步转化为末端环氧化物和氨基醇，证明了醛的对映选择性 α-氯化的合成效用在不损失光学纯度的情况下获得。氧化 α-氯醛，然后酯化，得到光学活性的 α-氯酯，而没有损失光学纯度。
• Ferroelectric liquid crystal polymer
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US04913839A1

  公开（公告）日：1990-04-03

  A ferroelectric liquid crystal polymer comprising the recurring units represented by the following general formula: ##STR1## in which k is an integer of from 1 to 30, R.sub.1 is ##STR2## R.sub.2 is --COOR.sub.3, --OCOR.sub.3, --OR.sub.3, or --R.sub.3, in which R.sub.3 is ##STR3## R.sub.4 is --CH.sub.3 or Cl, m is 0 or an integar of from 1 to 10, n is 0 or an integar of from 1 to 10, providing that n is not 0, when R.sub.4 is --CH.sub.3. The ferroelectric liquid crystal polymer of the present invention not only exhibits a ferroelectricity even at temperatures in the vicinity of a room temperature, but also has so fast response speed to the external factors as to be able to display motion pictures, and may be advantageously used as display elements for large size screens and a curved screens.

  本发明涉及一种铁电液晶聚合物，其由以下一般式所表示的重复单元组成：##STR1## 其中k为1到30的整数，R.sub.1为##STR2## R.sub.2为--COOR.sub.3，--OCOR.sub.3，--OR.sub.3或--R.sub.3，其中R.sub.3为##STR3## R.sub.4为--CH.sub.3或Cl，m为0或1到10的整数，n为0或1到10的整数，但当R.sub.4为--CH.sub.3时，n不为0。本发明的铁电液晶聚合物不仅在接近室温的温度下表现出铁电性，而且对外部因素的响应速度非常快，可以显示动态图像，并且可以优势地用作大尺寸屏幕和曲面屏幕的显示元件。
• Fodor-Csorba, K.; Vajda, A.; Bata, L., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1995, vol. 265, p. 97 - 110
  作者：Fodor-Csorba, K.、Vajda, A.、Bata, L.、Holly, S.、Gacs-Baitz, E.、et al.

  DOI：——

  日期：——

表征谱图