1,3,3-三甲氧基丙烯 - CAS号 17576-35-1

物化性质

沸点：

30 °C(Press: 0.5 Torr)
密度：

0.9667 g/cm3

计算性质

辛醇/水分配系数(LogP)：

0.3
重原子数：

9
可旋转键数：

4
环数：

0.0
sp3杂化的碳原子比例：

0.666
拓扑面积：

27.7
氢给体数：

0
氢受体数：

3

安全信息

危险等级：

3.2
海关编码：

2909199090
包装等级：

III
危险类别：

3.2
危险品运输编号：

UN 1993

SDS

SDS：3d29c8732314f8fce2cca4eeb5e4d35d

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Name:	1 3 3-Trimethoxypropene 96% (GC) Cis/Trans Mixture: 20/80 Material Safety Data Sheet
Synonym:	None
CAS:	17576-35-1

Section 1 - Chemical Product MSDS Name:1 3 3-Trimethoxypropene 96% (GC) Cis/Trans Mixture: 20/80 Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
17576-35-1	1,3,3-Trimethoxypropene	96	241-547-7

Hazard Symbols: XN
Risk Phrases: 10 22 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Harmful if swallowed. Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin irritation. May cause irritation and dermatitis. May cause cyanosis of the extremities.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Ingestion of large amounts may cause CNS depression.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause burning sensation in the chest.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.

Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame.
Avoid ingestion and inhalation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 17576-35-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 49 deg C ( 120.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.0600g/cm3
Molecular Formula: C6H12O3
Molecular Weight: 132.16

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 17576-35-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1,3,3-Trimethoxypropene - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: FLAMMABLE LIQUID, N.O.S.*
Hazard Class: 3
UN Number: 1993
Packing Group: III
IMO
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Hazard Class: 3.3
UN Number: 1993
Packing Group: III
RID/ADR
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 10 Flammable.
R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 33 Take precautionary measures against static
discharges.
S 37 Wear suitable gloves.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 17576-35-1: No information available.
Canada
CAS# 17576-35-1 is listed on Canada's NDSL List.
CAS# 17576-35-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 17576-35-1 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

作为反应物：

描述：

1,3,3-三甲氧基丙烯在 lead(IV) acetate 、苯作用下，生成 1,2-二乙酰氧基-1,3,3-三甲氧基-丙烷

参考文献：

名称：

Mueller; Plieninger, Chemische Berichte, 1959, vol. 92, p. 3009,3014

摘要：

DOI：
作为产物：

描述：

2-氯-1,1,3-三甲氧基-丙烷在 potassium tert-butylate 作用下，生成 1,3,3-三甲氧基丙烯

参考文献：

名称：

以1,3-二氧戊环为双键导向基团合成2-（2-烷氧基亚乙基）-1,3-二氧戊环

摘要：

标题化合物可以由具有二氧戊环环作为缩醛功能的2-氯缩醛前体合成，使得双键指向二氧戊环。

DOI：

10.1016/0040-4039(88)85303-6

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文献信息

Reagents and procedures for high-specificity labeling

申请人：Rutgers, The State University of New Jersey

公开号：US20040019104A1

公开（公告）日：2004-01-29

A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof: 1 wherein: (i) R 1 or R 2 , are each independently O − , S − , OR 3 or SR 3 with the provision that if either R 1 or R 2 is absent, the other remaining group is ═O or ═S; or R 1 and R 2 , together with the arsenic atom, form a ring according to one of the general structural Formulae (II), (III), (IV), or (V): 2 wherein R 3 is H, CH(OH)CH 2 OH, or (CH 2 ) q —Y, with q being 1-4 and Y being H, OH, NH 2 , SH, COOH, OAc, CONH 2 or CN, and Z represents a hydrocarbon chain comprising 2-4 singly or doubly bonded carbon atoms each of which may be further substituted with one or more of hydrogen, methyl, ethyl, 1-propyl, 2-propyl, methoxy, hydroxy, amino, carboxy, sulfo, oxo, thio, halo (fluoro, chloro, bromo, or fluoro) and (CH 2 ) n″ SO 3 , wherein n″ is 1 or 2; (ii) R 4 , R 5 , R 6 and R 7 are each independently H, F, OR 3 , R 3 , OAc, NH 2 , N(C 1 -C 4 alkyl) 2 , R 1 ; or R 4 with R 5 , or R 6 together with R 7 , or both, form a ring; (iii) R 8 is a linear or branched optionally substituted spacer having a minimum length of approximately 1.5 and a maximum length of approximately 15 Ångstroms; and (iv) X is a detectable group. Methods of using the bis-phenylarsine molecule also are provided.

根据通用结构式（I）及其互变异构体、酸和盐，具有两个挂链苯基砷基的分子：其中：（i）R1或R2分别独立为O−、S−、OR3或SR3，但须注意如果R1或R2中有一个不存在，则另一个剩余基团为═O或═S；或者R1和R2与砷原子一起形成一个环，符合通用结构式（II）、（III）、（IV）或（V）之一：其中R3为H、CH(OH)CH2OH或(CH2)q—Y，其中q为1-4，Y为H、OH、NH2、SH、COOH、OAc、CONH2或CN，Z代表一个含有2-4个单键或双键碳原子的碳氢链，每个碳原子可以进一步被氢、甲基、乙基、1-丙基、2-丙基、甲氧基、羟基、氨基、羧基、磺酰基、羰基、硫基、卤素（氟、氯、溴或氟）和(CH2)n″SO3等取代，其中n″为1或2；（ii）R4、R5、R6和R7各自独立为H、F、OR3、R3、OAc、NH2、N(C1-C4烷基)2或R1；或者R4与R5，或R6与R7，或两者一起形成一个环；（iii）R8为线性或支链的可选取代的间隔物，其最小长度约为1.5，最大长度约为15埃；（iv）X为可检测的基团。还提供了使用双苯基砷分子的方法。
Folic acid derivatives and use in radio-assay

申请人：SmithKline Instruments, Inc.

公开号：US03989812A1

公开（公告）日：1976-11-02

Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.

从叶酸前体pteroyl-.gamma.-glutamyl-tyrosines中通过碘化反应制备的新型叶酸衍生物可用于放射性测定生物液体中的叶酸及其代谢物。其中使用的放射性同位素为I.sup.125或I.sup.131。
Novel selenium-containing merocyanine dyes

申请人：Eastman Kodak Company

公开号：US04885366A1

公开（公告）日：1989-12-05

A merocyanine dye having the formula: ##STR1## wherein: R.sub.1 and R.sub.2 independently are H, alkyl, alkoxy or aryl, R.sub.7 and R.sub.8 are H or any of R.sub.1 and R.sub.2, R.sub.1 and R.sub.7, R.sub.2 and R.sub.8 can together comprise the atoms necessary to form a fused aromatic ring on the benzene radical to which they are attached; R.sub.5 and R.sub.6 comprise alkyl of from 1-18 carbon atoms provided that the sum of the carbon atoms in R.sub.5 and R.sub.6 is at least 8; R.sub.9 is an alkylene group of 2-9 nuclear carbon and hetero atoms; and Z.sup.+ is a cation. This dye is useful in a method for inactivating viruses comprising contacting the viruses with the compound and exposing the resulting mixture to visible light to excite and inactivate the viruses. The compounds are also useful in the irradiation-induced inactivation of leukemia cells.

一种具有以下公式的美洛氰染料：##STR1## 其中：R.sub.1和R.sub.2独立地为H，烷基，烷氧基或芳基，R.sub.7和R.sub.8为H或R.sub.1和R.sub.2中的任意一种，R.sub.1和R.sub.7，R.sub.2和R.sub.8可以一起包含所需原子，以形成与它们附着的苯基上的融合芳环；R.sub.5和R.sub.6包括1-18个碳原子的烷基，前提是R.sub.5和R.sub.6中碳原子的总和至少为8；R.sub.9是具有2-9个核碳和杂原子的烷基；Z.sup.+是一个阳离子。该染料在灭活病毒的方法中有用，包括将病毒与化合物接触，并将产生的混合物暴露于可见光下以激发和灭活病毒。该化合物也有用于放射线诱导的白血病细胞灭活。
Live cell biosensors

申请人：The Scripps Research Institute

公开号：US07592188B2

公开（公告）日：2009-09-22

The invention provides dyes, biosensors, and methods for using the dyes and biosensors to detect selected target molecules. The biosensors have a binding domain and a dye, or a dye which is attached directly to the target of interest. Binding domains contemplated by the invention include biomolecules or fragments of biomolecules that interact with target molecules of interest and can be specific to a given conformational state or covalent modification of the molecule (e.g. phosphorylation). In one embodiment, the binding domain of a biosensor is a single chain variable fragment (scFv) with a dye of the invention linked to a CDR3 region. The invention also provides environmentally sensitive dyes useful for detecting changes in the binding, conformational change, or posttranslational modification of the selected target.

本发明提供了染料、生物传感器以及使用这些染料和生物传感器检测所选目标分子的方法。生物传感器具有结合域和染料，或者是直接连接到感兴趣目标的染料。本发明所考虑的结合域包括与目标分子作用并且可以特异性地与分子的给定构象状态或共价修饰相互作用的生物分子或生物分子片段（例如磷酸化）。在一个实施例中，生物传感器的结合域是单链可变片段（scFv），具有本发明的染料连接到CDR3区域。本发明还提供了对环境敏感的染料，用于检测所选目标的结合、构象变化或后转录后修饰的变化。
Visible diode laser induced fluorescence detection in liquid chromatography after precolumn derivatization of thiols

作者：Arjan J. G. Mank、Ernst J. Molenaar、Henk. Lingeman、Cees. Gooijer、Udo A. T. Brinkman、Nel H. Velthorst

DOI：10.1021/ac00065a006

日期：1993.9.1

New cyanine labels containing only a single active group for the chemical derivatization of thiols were synthesized in order to apply visible diode laser induced fluorescence (DIO-LIF) detection in conventional-size liquid chromatography (LC). 2-Mercaptobenzothiazole (MBT) was selected as test compound. The most appropriate label was CY5.4a-IA, a sulfonated dicarbocyanine with a iodoacetamide reactive group. The detection limit of labeled MBT in the LC-DIO-LIF system was 8 X 10(-12) M. The detection limit of MBT was 1 x 10(-9) M; lower concentrations are not labeled quantitatively. The injection repeatability was 1.0% (n = 6), the reaction repeatability was 3.0% (n = 6), and linearity was observed from 2.5 X 10(-9) to 1.0 x 10(-5) M. As an example, MBT-spiked river water and urine samples were derivatized with CY5.4a-IA and analyzed by LC-DIO-LIF. Hardly any interference was found. The method compares very favorably with existing techniques.

1,3,3-三甲氧基丙烯 | 17576-35-1

分子结构分类

物化性质

计算性质

安全信息

SDS

反应信息

文献信息

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