(3R)-2,2-dimethyl-3-propan-2-ylcyclopentan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R)-2,2-dimethyl-3-propan-2-ylcyclopentan-1-one
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: OAVKVOHNMAHPFW-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (3R)-2,2-dimethyl-3-propan-2-ylcyclopentan-1-one 在 吡啶 、 盐酸羟胺 作用下， 以 异丙醇 为溶剂， 反应 12.0h， 生成 (1E,3R)-N-羟基-3-异丙基-2,2-二甲基环戊烷亚胺
  参考文献：
  名称：

  Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction

  摘要：

  Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00851-6
• 作为产物：
  描述：

  甲基环戊烯醇酮 在 copper(l) iodide 正丁基锂 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 反应 31.0h， 生成 (3R)-2,2-dimethyl-3-propan-2-ylcyclopentan-1-one
  参考文献：
  名称：

  Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction

  摘要：

  Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00851-6

文献信息

• Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction
  作者：Philip Magnus、Michael J Waring、Cyril Ollivier、Vince Lynch

  DOI：10.1016/s0040-4039(01)00851-6

  日期：2001.7

  Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.