4-(烯丙基氧基)间二甲苯 | 93981-82-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-(烯丙基氧基)间二甲苯
• 英文名称: 2,4-dimethyl(allyloxy)benzene
• 英文别名: allyl-(2,4-dimethyl-phenyl)-ether；Allyl-(2,4-dimethyl-phenyl)-aether；4-Allyloxy-m-xylol；4-(allyloxy)-m-xylene；2,4-dimethyl-1-prop-2-enoxybenzene
• CAS: 93981-82-9
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: ZJSJAHBINHESJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  4-(烯丙基氧基)间二甲苯 在 sodium tetrahydroborate 、 四(三苯基膦)钯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以93%的产率得到2,4-二甲基苯酚
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q
• 作为产物：
  描述：

  2,4-二甲基-1-碘苯 、 烯丙醇 在 copper(l) iodide 、 3,4,7,8-四甲基-1,10-菲罗啉 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以86%的产率得到4-(烯丙基氧基)间二甲苯
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q

文献信息

• Organoaluminum-promoted rearrangement of allyl phenyl ethers
  作者：Keiji Maruoka、Junko Sato、Hiroshi Banno、Hisashi Yamamoto

  DOI：10.1016/s0040-4039(00)94559-3

  日期：1990.1

  The Claisen rearrangement of allyl phenyl ethers with exceptionally bulky, oxygenophilic methylaluminum bis(4-bromo-2,6-di-tert-butylphenoxide) (reagent A) is found to exhibit an unusual behavior not observable in the ordinary thermal and Lewis acid-induced rearrangement.

  发现烯丙基苯基醚的Claisen重排与异常庞大的，亲水性的甲基铝双（4-溴-2,6-二叔丁基苯氧酚）（试剂A）表现出在普通热和路易斯酸中无法观察到的异常行为。引起的重排。
• Water‐Accelerated Claisen Rearrangements
  作者：Peter Wipf、Sonia Rodríguez

  DOI：10.1002/1615-4169(200206)344:3/4<434::aid-adsc434>3.0.co;2-#

  日期：2002.6

  Allyl aryl ethers undergo accelerated Claisen and [1,3] rearrangements in the presence of a mixture of trialkylalanes and water or aluminoxanes. The ratio of ortho-, meta-, and para-Claisen products depends to a large extent on the presence of water and to a much lesser extent on the nature of the alane.

  在三烷基丙烷和水或铝氧烷的混合物存在下，烯丙基芳基醚经历加速的克莱森和 [1,3] 重排。邻位、间位和对位克莱森产物的比例在很大程度上取决于水的存在，而在较小程度上取决于铝烷的性质。
• HIGH PENETRATION COMPOSITIONS AND USES THEREOF
  申请人：Yu Chongxi

  公开号：US20090238763A1

  公开（公告）日：2009-09-24

  The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents (NSAIAs), which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes. For example, the HPPs can be locally delivered to an action site of a condition with a high concentration due to their ability of penetrating biological barriers and thus obviate the need for a systematic administration. For another example, the HPPs herein can be systematically administer to a biological subject and enter the general circulation with a faster rate.

  本发明涉及新型高渗透性组合物或高渗透性前药（HPP）的组成和用途，特别是用于非甾体抗炎药（NSAIAs）的HPP，其能够高效地穿过生物屏障。这里的HPP能够在穿过生物屏障后转化为父活性药物或药物代谢物，从而可以治疗与父药物或代谢物相关的疾病。此外，由于能够穿过生物屏障，这里的HPP能够到达父药物可能无法进入或无法在目标区域产生足够浓度的区域，从而提供新的治疗方法。这里的HPP可以通过各种给药途径给予受试者。例如，由于其穿透生物屏障的能力，HPP可以在局部给药到疾病作用部位并以高浓度存在，从而避免系统性给药的需要。另一个例子是，这里的HPP可以被系统性地给药到生物体内，并以更快的速率进入循环系统。
• Photochemical Radical Cation Cycloadditions of Aryl Vinyl Ethers
  作者：Sota Adachi、Genki Horiguchi、Hidehiro Kamiya、Yohei Okada

  DOI：10.1002/ejoc.202201207

  日期：2022.11.25

  TiO2 photochemical [2+2] and [4+2] cycloadditions using aryl vinyl ethers as radical cation precursors. The construction of various four- and six-membered rings is made possible by these radical cation cycloadditions. The diene is found to be more radicalophilic than the alkene and effectively traps the radical cation of the aryl vinyl ethers.

  在此，我们报道了使用芳基乙烯基醚作为自由基阳离子前体的 TiO 2光化学 [2+2] 和 [4+2] 环加成反应。通过这些自由基阳离子环加成，可以构建各种四元环和六元环。发现二烯比烯烃更亲自由基并且有效地捕获芳基乙烯基醚的自由基阳离子。
• Zur Kinetik derClaisen-Umlagerung. Zur Kenntnis derClaisen-Umlagerung VIII
  作者：F. Kalberer、H. Schmid

  DOI：10.1002/hlca.19570400103

  日期：——

  Es wurde die thermische Umlagerung des radioaktiven (2,6-Di-methyl-4-allylphenyl)-allyläthers und des 2,4-Dimethylphenyl-allyläthers kinetisch analysiert und die daraus ermittelten Reaktionsgrössen mit denjenigen anderer Claisen-Umlagerungen verglichen.

  Es wurde与radiaktiven（2,6-Di-methyl-4-allylphenyl）-allyläthers和2,4,4-Dimethylphenyl-allyläthers的热分析和daraus ermitteltenReaktionsgrössenmit denjenigenchen anderer Claisen -Uml。