methyl 3-p-chloro-tetrafluorophenyl acrylate | 137114-70-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl 3-p-chloro-tetrafluorophenyl acrylate
• 英文别名: methyl (E)-3-(4-chloro-2,3,5,6-tetrafluorophenyl)prop-2-enoate
• CAS: 137114-70-6
• 化学式: C₁₀H₅ClF₄O₂
• 分子量: 268.595
• InChiKey: AIHOZKIFUJFJJI-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.08
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  氯五氟苯 以 乙醚 为溶剂， 反应 1.5h， 生成 methyl 3-p-chloro-tetrafluorophenyl acrylate
  参考文献：
  名称：

  A Novel One-Pot Synthesis of Fluorinated α,β-Unsaturated Esters

  摘要：

  The reaction of pentafluorophenylmethylene-triphenylarsorane or p-chloro-tetrafluorophenylmethyl-enetriphenylarsorane, generated in situ from methylene-triphenylarsorane and hexafluorobenzene or chloropenta-fluorobenzene, with bromoacetates giving excellent yields of 3-pentafluorophenyl or 3-p-chloro-tetrafluorophenyl alpha,beta-unsaturated esters with high steroselectivity is described.

  DOI：

  10.1080/00397919108021289

文献信息

• A Novel One-Pot Synthesis of Fluorinated α,β-Unsaturated Esters
  作者：Yanchang Shen、Yuejun Xiang

  DOI：10.1080/00397919108021289

  日期：1991.6

  The reaction of pentafluorophenylmethylene-triphenylarsorane or p-chloro-tetrafluorophenylmethyl-enetriphenylarsorane, generated in situ from methylene-triphenylarsorane and hexafluorobenzene or chloropenta-fluorobenzene, with bromoacetates giving excellent yields of 3-pentafluorophenyl or 3-p-chloro-tetrafluorophenyl alpha,beta-unsaturated esters with high steroselectivity is described.