2,3-dihydroxypropyl (E)-3-(4-methoxyphenyl)prop-2-enoate | 220852-57-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2,3-dihydroxypropyl (E)-3-(4-methoxyphenyl)prop-2-enoate
• CAS: 220852-57-3
• 化学式: C₁₃H₁₆O₅
• 分子量: 252.267
• InChiKey: TWNMUIOZHQVLGC-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  反式-4-甲氧基肉桂酸 、 甘油 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以20%的产率得到2,3-dihydroxypropyl (E)-3-(4-methoxyphenyl)prop-2-enoate
  参考文献：
  名称：

  4-甲氧基肉桂酰基甘油的制备与表征

  摘要：

  AbstractGlycerol was reacted with 4‐methoxy cinnamic acid to prepare the corresponding 4‐methoxy cinnamoyl glycerol. The reaction proceeded in toluene under reflux conditions with p‐toluenesulfonic acid catalyst. Reaction of equimolar amounts of reactants produced the monoester in 20% yield after 2 h. The product was isolated and characterized by FTIR, mass spectrometry, and NMR techniques. Results of mass spectrometry and NMR experiments showed that the ester linkage formed between the carboxylic acid and the primary hydroxyl of glycerol. The ester displayed strong absorbance between 250 and 350 nm and shows potential as a UV filter in formulations where hydrophilic compounds are advantageous.

  DOI：

  10.1007/s11746-008-1197-y

文献信息

• [EN] USE OF COMPOUNDS RESULTING FROM A SUGAR POLYOL OR FROM A DEHYDROGENATED SUGAR POLYOL DERIVATIVE AS A UV-SCREENING AGENT; ANTISUN COMPOSITIONS CONTAINING SAME; AND NOVEL COMPOUNDS<br/>[FR] UTILISATION DES COMPOSÉS OBTENUS À PARTIR D'UN POLYOL DE TYPE SUCRE OU D'UN DÉRIVÉ DÉSHYDROGÉNÉ DE POLYOL DE TYPE SUCRE À TITRE D'AGENT DE FILTRATION UV ; COMPOSITIONS ANTISOLAIRES LES CONTENANT ; ET NOUVEAUX COMPOSÉS
  申请人：OREAL

  公开号：WO2012010554A1

  公开（公告）日：2012-01-26

  The present invention relates to the cosmetic use, as an agent for screening out UV radiation, of compounds resulting from a sugar polyol or from a dehydrogenated sugar polyol derivative of formula (I) or (II) in which A1 and A2 denote UV-screening groups; Z1 and Z2 a sugar polyol group or a dehydrogenated sugar polyol derivative such that the product of formula (I) has in its structure from 1 to 4 -OH groups remaining and optionally from 1 to 2 -COOH groups. The present invention also relates to a composition comprising, in a cosmetically acceptable medium, at least one compound of formula (I) or (II). The present invention also relates to novel compounds resulting from a sugar polyol or from a dehydrogenated sugar polyol derivative of formula (I) or (II).

  本发明涉及一种化妆品用途，即作为筛选紫外线辐射的剂量，使用公式（I）或（II）的糖多醇或去氢糖多醇衍生物所得化合物，其中A1和A2表示紫外线筛选基团；Z1和Z2表示糖多醇基团或去氢糖多醇衍生物，使得公式（I）的产物在其结构中具有1-4个-OH基团和可选的1-2个-COOH基团。本发明还涉及一种组合物，其中包含在化妆品可接受介质中的至少一种公式（I）或（II）的化合物。本发明还涉及由公式（I）或（II）的糖多醇或去氢糖多醇衍生物所得的新化合物。
• Uv Filters
  申请人：Carola Christophe

  公开号：US20080038213A1

  公开（公告）日：2008-02-14

  The invention relates to compounds of the formula (I) or (II), to compositions which comprise such compounds, to corresponding processes for the preparation of the compounds or the compositions comprising same, and to the use thereof as light-protection filters.

  本发明涉及式（I）或（II）化合物，包括这些化合物的组合物，制备这些化合物或包含它们的组合物的相应过程，以及将它们用作光保护过滤器的用途。
• HAIR GROWTH INHIBITORS AND COMPOSITIONS CONTAINING THE SAME
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1352637A1

  公开（公告）日：2003-10-15

  A hair growth inhibitor contains, as an active ingredient, at least one herb selected from the group consisting of phellodendron bark, houttuynia, rice bran, mulberry tree bark, Japanese coptis, thyme, peach seed, nettle, calendula, wild rose and balm mint or the extract thereof and various skin external application compositions such as cosmetic compositions to be used on the outer skin is prepared by mixing these active ingredients with other aqueous phase ingredients and oil phase ingredients according to conventional methods.

  一种毛发生长抑制剂含有至少一种选自黄柏、蕺菜、米糠、桑树皮、日本黄连、百里香、桃仁、荨麻、金盏花、野玫瑰和香脂薄荷的草本植物或其提取物作为活性成分，通过将这些活性成分与其他水相成分和油相成分按常规方法混合，制备出各种皮肤外用组合物，如用于外层皮肤的化妆品组合物。
• Hair growth inhibitors and composition containing same
  申请人：Ishino Akihiro

  公开号：US20050175576A1

  公开（公告）日：2005-08-11

  A hair growth inhibitor contains, as an active ingredient, at least one herb selected from the group consisting of phellodendron bark, houttuynia, rice bran, mulberry tree bark, Japanese coptis, thyme, peach seed, nettle, calendula, wild rose and balm mint or the extract thereof and various skin external application compositions such as cosmetic compositions to be used on the outer skin is prepared by mixing these active ingredients with other aqueous phase ingredients and oil phase ingredients according to conventional-methods.

  一种毛发生长抑制剂含有至少一种草药作为活性成分，这些草药选自以下组别 黄柏 黄柏 蕺菜 米糠、桑树皮、日本 百里香 百里香、桃仁、荨麻 金盏花 将这些活性成分与其他水相成分和油相成分按照传统方法混合，可制备出各种皮肤外用组合物，如用于外层皮肤的化妆品组合物。
• WATANABE T.; HAYASHI K.; YOSHIMATSU S.; SAKAI K.; TAKEYAMA S.; TAKASHIMA +, J. MED. CHEM., 1980, 23, NO 1, 50-59
  作者：WATANABE T.、 HAYASHI K.、 YOSHIMATSU S.、 SAKAI K.、 TAKEYAMA S.、 TAKASHIMA +

  DOI：——

  日期：——