| 145306-83-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 145306-83-8
• 化学式: C₂₁H₂₆O₄
• 分子量: 342.435
• InChiKey: OXYLSMWKIQXBIW-WLEBJDBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  25.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 L-(+)-酒石酸二异丙酯 、 4 A molecular sieve 作用下， 以70%的产率得到
  参考文献：
  名称：

  Katsuki-Sharpless asymmetric epoxidation of allylic-homoallylic alcohols sharing the central olefinic bond

  摘要：

  Katsuki-Sharpless asymmetric epoxidation of four isomeric chiral allylic-homoallylic diols sharing the central olefinic bond has been examined. Among these, three heptenediols having (3E,2R,6R), (3E,2R,6S), and (3Z,2R,6R) configurations underwent diastereospecific epoxidation to give the corresponding epoxides each as a single epimer in the presence of L-DIPT, but the diol having (3Z,2R,6S) configuration did not show high diastereoselection in the presence of either L- or D-DIPT. Interestingly, (3Z,2R,6R)-diol afforded the same epoxide irrespective of the chirality of DIPT used.

  DOI：

  10.1016/s0040-4039(00)79094-0
• 作为产物：
  描述：

  (R)-4-benzyloxy-3-hydroxy-1-butyne 在 Lindlar's catalyst 氢气 作用下， 生成
  参考文献：
  名称：

  Katsuki-Sharpless asymmetric epoxidation of allylic-homoallylic alcohols sharing the central olefinic bond

  摘要：

  Katsuki-Sharpless asymmetric epoxidation of four isomeric chiral allylic-homoallylic diols sharing the central olefinic bond has been examined. Among these, three heptenediols having (3E,2R,6R), (3E,2R,6S), and (3Z,2R,6R) configurations underwent diastereospecific epoxidation to give the corresponding epoxides each as a single epimer in the presence of L-DIPT, but the diol having (3Z,2R,6S) configuration did not show high diastereoselection in the presence of either L- or D-DIPT. Interestingly, (3Z,2R,6R)-diol afforded the same epoxide irrespective of the chirality of DIPT used.

  DOI：

  10.1016/s0040-4039(00)79094-0