5,6-Dimethoxy-3-phenoxy-N-1H-tetrazol-5-yl-benzo[b]thiophene-2-carboxamide | 122024-53-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,6-Dimethoxy-3-phenoxy-N-1H-tetrazol-5-yl-benzo[b]thiophene-2-carboxamide
• 英文别名: benzo[b]thiophene-2-carboxamide, 5,6-dimethoxy-3-phenoxy-N-1H-tetrazol-5-yl-；5,6-dimethoxy-3-phenoxy-N-(2H-tetrazol-5-yl)-1-benzothiophene-2-carboxamide
• CAS: 122024-53-7
• 化学式: C₁₈H₁₅N₅O₄S
• 分子量: 397.414
• InChiKey: XUPGMSOTSFAJPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  potassium phenolate 在 sodium hydroxide 、 N,N'-羰基二咪唑 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 13.25h， 生成 5,6-Dimethoxy-3-phenoxy-N-1H-tetrazol-5-yl-benzo[b]thiophene-2-carboxamide
  参考文献：
  名称：

  Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

  摘要：

  The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarbox-amidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compounds 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.

  DOI：

  10.1021/jm00083a023

文献信息

• Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0299457A2

  公开（公告）日：1989-01-18

  Novel benzothiophenes having antiallergic activity and both novel and other selected benzo­thiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolyl­carboxamides of the benzothiophenes.

  具有抗过敏活性的新型苯并噻吩，以及具有治疗急性呼吸窘迫综合征活性的新型苯并噻吩和其他精选苯并噻吩。本发明的苯并噻吩尤其是苯并噻吩的 2-四唑甲酰胺。
• Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
  申请人：——

  公开号：US20030055095A1

  公开（公告）日：2003-03-20

  The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor.

  本发明提供了一种治疗或预防中性粒细胞趋化的方法。具体来说，本发明提供了一种通过向患者施用 MEK 抑制剂来治疗或预防中性粒细胞迁移的方法。
• CONNOR, DAVID T.;MULLICAN, MICHAEL D.;SORENSON, RODERICK J.;THUESON, DAVI+
  作者：CONNOR, DAVID T.、MULLICAN, MICHAEL D.、SORENSON, RODERICK J.、THUESON, DAVI+

  DOI：——

  日期：——
• US4910317A
  申请人：——

  公开号：US4910317A

  公开（公告）日：1990-03-20
• US4931459A
  申请人：——

  公开号：US4931459A

  公开（公告）日：1990-06-05