(3aS,4S,6S,6aS)-tetrahydro-2,2,4,6-tetramethyl-5-phenyl-4H-phospholo[3,4-d]-1,3-dioxole | 259535-67-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aS,4S,6S,6aS)-tetrahydro-2,2,4,6-tetramethyl-5-phenyl-4H-phospholo[3,4-d]-1,3-dioxole
• 英文别名: (3aS,4S,6S,6aS)-2,2,4,6-tetramethyl-5-phenyl-3a,4,6,6a-tetrahydrophospholo[3,4-d][1,3]dioxole
• CAS: 259535-67-6
• 化学式: C₁₅H₂₁O₂P
• 分子量: 264.304
• InChiKey: ROXJGUXMDFWCDU-CDGCEXEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3aS,4S,6S,6aS)-tetrahydro-2,2,4,6-tetramethyl-5-phenyl-4H-phospholo[3,4-d]-1,3-dioxole 生成 (3aS,4S,6S,6aS)-2,2,4,6-Tetramethyl-5-phenyl-tetrahydro-phospholo[3,4-d][1,3]dioxole 5-selenide
  参考文献：
  名称：

  New chiral monodentate phospholane ligands by highly stereoselective hydrophosphination

  摘要：

  New chiral phospholanes 6 were prepared in both enantiomeric forms starting from L- and D-tartaric acid. The key step in the synthetic sequence is the double hydrophosphination of unsaturated chiral bis(lactone) 9 by NaPhPH(BH3). This method was used for the first time in the formation of chiral phospholanes. The structure of phospholane 6a was confirmed by X-ray crystallography. sigma-Donor properties of the phospholanes were estimated by measurement of (1)J((PSe)-P-31-Se-77) coupling constants in the corresponding phosphine selenides. The new phospholanes were tested as ligands in the Rh-catalyzed enantioselective hydrogenation of functionalized standard olefins (65-92% ee). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.06.047
• 作为产物：
  描述：

  3,4-di-O-isopropylidene-D-mannitol 在 正丁基锂 、 三乙基硼氢化锂 、 potassium carbonate 作用下， 以 四氢呋喃 、 吡啶 、 甲醇 、 正己烷 为溶剂， 反应 30.0h， 生成 (3aS,4S,6S,6aS)-tetrahydro-2,2,4,6-tetramethyl-5-phenyl-4H-phospholo[3,4-d]-1,3-dioxole
  参考文献：
  名称：

  从碳水化合物中合成功能化磷烷的高度灵活的合成路线

  摘要：

  通过用磷化二锂试剂置换合适的二甲磺酸酯或环状硫酸酯，可以容易地从d-甘露醇制备高度官能化的膦烷15、17和26以及其中膦烷碳2和碳5的构型反转的相应非对映异构体。制备这些配体的二醇也可以转化为二芳基亚膦酸酯配体。还描述了产生带有半可溶性叔丁基硫基的相关单膦的途径。这些配体和相关脱保护衍生物的配合物可能可用于有机和水介质中的对映选择性催化。

  DOI：

  10.1021/jo991762j

文献信息

• Asymmetric catalysis based on chiral phospholanes and hydroxyl phospholanes
  申请人：The Penn State Research Foundation

  公开号：US06727377B2

  公开（公告）日：2004-04-27

  Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.

  来自手性天然产物的手性膦配体，包括D-甘露醇和酒石酸。这些配体含有一个或多个含有多个手性中心的5元磷环，可在不对称反应中提供高立体选择性。
• Highly Flexible Synthetic Routes to Functionalized Phospholanes from Carbohydrates
  作者：Yuan-Yong Yan、T. V. RajanBabu

  DOI：10.1021/jo991762j

  日期：2000.2.1

  Highly functionalized phospholanes 15, 17, and 26 and the corresponding diastereomers in which the configurations of the phospholane carbon-2 and carbon-5 are inverted can be readily prepared from d-mannitol by displacement of the appropriate dimesylate or cyclic sulfate with dilithiumphosphide reagents. The diols from which these ligands are prepared can also be converted into diarylphosphinite ligands

  通过用磷化二锂试剂置换合适的二甲磺酸酯或环状硫酸酯，可以容易地从d-甘露醇制备高度官能化的膦烷15、17和26以及其中膦烷碳2和碳5的构型反转的相应非对映异构体。制备这些配体的二醇也可以转化为二芳基亚膦酸酯配体。还描述了产生带有半可溶性叔丁基硫基的相关单膦的途径。这些配体和相关脱保护衍生物的配合物可能可用于有机和水介质中的对映选择性催化。
• Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino acids and esters
  作者：Wenge Li、Zhaoguo Zhang、Dengming Xiao、Xumu Zhang

  DOI：10.1016/s0040-4039(99)01254-x

  日期：1999.9

  A chiral hydroxyl bisphospholane, 1,2-bis[(2S,3S,4S,5S)-3,4-dihydroxyl-2,5-dimethylphospholanyl]benzene (4), was synthesized from readily available d-mannitol. Its Rh(I) complex catalyzes asymmetric hydrogenation of dehydroamino acids and their ester derivatives with excellent enantioselectivities (98 to >99% ee).

  由容易获得的d-甘露糖醇合成手性羟基双膦，1,2-双[（2 S，3 S，4 S，5 S）-3,4-二羟基-2,5-二甲基磷杂环戊基]苯（4） 。它的Rh（I）配合物催化脱氢氨基酸及其酯衍生物的不对称氢化，具有出色的对映选择性（98至> 99％ee）。
• Synthesis of Chiral Hydroxyl Phospholanes from <scp>d</scp>-mannitol and Their Use in Asymmetric Catalytic Reactions
  作者：Wenge Li、Zhaoguo Zhang、Dengming Xiao、Xumu Zhang

  DOI：10.1021/jo000066c

  日期：2000.6.1

  Strategies for protection and deprotection of OH-groups in the presence of phosphines have been explored. Rate acceleration in the Baylis-Hillman reaction was observed when a hydroxyl phosphine was used as the catalyst. Rhodium complexes with chiral bisphospholanes are highly enantioselective catalysts for the asymmetric hydrogenation of various kinds of functionalized olefins such as dehydroamino

  手性羟基一膦3 [（2S，3S，4S，5S）-3,4-二羟基-2，5-二甲基-1-苯基膦烷]和双膦酸酯5a [1,2-双[（2S，3S，4S，5S） -3,4-二羟基-2,5-二甲基磷杂环戊烷基]苯]和5b [1,2-双[（2S，3S，4S，5S）-2,5-二乙基-3,4-二羟基磷杂环戊基]苯]从现成的D-甘露醇中以高收率获得。已经研究了在膦存在下保护和脱保护OH-基团的策略。当使用羟基膦作为催化剂时，在Baylis-Hillman反应中观察到速率加速。铑与手性双膦酸酯的络合物是高度对映选择性的催化剂，用于各种官能化烯烃（如脱氢氨基酸衍生物，衣康酸衍生物和烯酰胺）的不对称氢化。
• New chiral monodentate phospholane ligands by highly stereoselective hydrophosphination
  作者：Vitaliy Bilenko、Anke Spannenberg、Wolfgang Baumann、Igor Komarov、Armin Börner

  DOI：10.1016/j.tetasy.2006.06.047

  日期：2006.8

  New chiral phospholanes 6 were prepared in both enantiomeric forms starting from L- and D-tartaric acid. The key step in the synthetic sequence is the double hydrophosphination of unsaturated chiral bis(lactone) 9 by NaPhPH(BH3). This method was used for the first time in the formation of chiral phospholanes. The structure of phospholane 6a was confirmed by X-ray crystallography. sigma-Donor properties of the phospholanes were estimated by measurement of (1)J((PSe)-P-31-Se-77) coupling constants in the corresponding phosphine selenides. The new phospholanes were tested as ligands in the Rh-catalyzed enantioselective hydrogenation of functionalized standard olefins (65-92% ee). (c) 2006 Elsevier Ltd. All rights reserved.