<(4,5-diphenyl-1H-imidazol-2-yl)thio>acetic acid hydrazide | 53015-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: <(4,5-diphenyl-1H-imidazol-2-yl)thio>acetic acid hydrazide
• 英文别名: 2-(4,5-Diphenylimidazol-2-ylthio)-acethydrazid；4,5-Diphenyl-imidazolyl-(2)-mercaptoessigsaeure-hydrazid；(4,5-diphenyl-1H-imidazol-2-ylsulfanyl)-acetic acid hydrazide；[(4,5-Diphenyl-1h-imidazol-2-yl)thio]acetic acid hydrazide；2-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]acetohydrazide
• CAS: 53015-37-5
• 化学式: C₁₇H₁₆N₄OS
• 分子量: 324.406
• InChiKey: LSZVIHSOAWBTPN-UHFFFAOYSA-N

物化性质

• 熔点：
  162-163 °C(Solv: ethanol (64-17-5))
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  <(4,5-diphenyl-1H-imidazol-2-yl)thio>acetic acid hydrazide 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanylmethyl)-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione
  参考文献：
  名称：

  Gursoy; Demirayak; Cesur, Pharmazie, 1990, vol. 45, # 4, p. 246 - 250

  摘要：

  DOI：
• 作为产物：
  描述：

  4,5-Diphenyl-imidazolyl-(2)-mercaptoessigsaeure 在 乙酸酐 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 1.33h， 生成 <(4,5-diphenyl-1H-imidazol-2-yl)thio>acetic acid hydrazide
  参考文献：
  名称：

  Gursoy; Demirayak; Cesur, Pharmazie, 1990, vol. 45, # 4, p. 246 - 250

  摘要：

  DOI：

文献信息

• Synthesis, Characterization and Evaluation of Antimicrobial Activity of Some Novel 1,2,4-Triazoles and 1,3,4-Thiadiazoles Bearing Imidazole Nuclues
  作者：Mohamed Reda Aouad、Nadjet Rezki、Mohamed Kasmi、Linda Aouad、Merieme A. Rezki

  DOI：10.3987/com-12-12456

  日期：——

  A series of N-1-[(4,5-di and 1,4,5-triphenylimidazol-2-yl)thioacetyl]-N-4-alkyl/aryl-thiosemicarbazides 3-7 were synthesized from (4,5-di and 3,4,5-triphenylimidazol-2-yl)thioacetic acid hydrazide 1, 2. The treatment of compounds 3-7 with NaOH gave 5- [(4,5-di and 1,4,5-triphenylimidazol-2-yl)-3-thiomethyl]-4-alkyl/aryl-2H-1,2,4-triazoles-3-thione 8-12, while the acidic treatment of compounds 3-7 afforded 5-[(4,5-di- and 1,4,5-triphenylimidazol-2-yl)-3-thiomethyl]-2-alkyl/arylamino-1,3,4-thiadiazoles 13-17. Moreover, potassium hydrazinecarbothionates 18, 19 were obtained from the reaction of acyl hydrazides 1, 2 with carbon disulfides in basic media and converted into 4-amino-1,2,4-triazole-3-thiones 20, 21 and 1,3,4-thiadiazole-2-thiols 22, 23 by the treatment with hydrazine hydrate and sulfuric acid, respectively. All newly synthesized compounds were screened for their antimicrobial activity.
• Gursoy; Karali; Buyuktimkin, Il Farmaco, 1996, vol. 51, # 6, p. 437 - 442
  作者：Gursoy、Karali、Buyuktimkin、Demirayak、Ekinci、Ozer

  DOI：——

  日期：——
• GURSOY, A.;DEMIRAYAK, S.;CESUR, Z.;REISCH, J.;OTUK, G., PHARMAZIE, 45,(1990) N, C. 246-250
  作者：GURSOY, A.、DEMIRAYAK, S.、CESUR, Z.、REISCH, J.、OTUK, G.

  DOI：——

  日期：——