N-甲基-1-芘胺 | 22965-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: N-甲基-1-芘胺
• 英文名称: 1-methylaminopyrene
• 英文别名: methyl-pyren-1-yl-amine；Methyl-pyren-1-yl-amin；1-Methylamino-pyren；1-Pyrenamine, N-methyl-；N-methylpyren-1-amine
• CAS: 22965-22-6
• 化学式: C₁₇H₁₃N
• 分子量: 231.297
• InChiKey: UCISVZJFGFQPKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  N-甲基-1-芘胺 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Molecular Wire Behavior in π-Stacked Donor-Bridge-Acceptor Tertiary Arylureas

  摘要：

  The synthesis, structure, and electronic properties of a series of tertiary polyarylureas possessing pyrene and dimethylaniline capping groups separated by zero-to-four phenylenediamine bridging groups are described. These molecules adopt folded pi-stacked structures. The dynamics of photoinduced charge separation and charge recombination are investigated by femtosecond broadband pump-probe spectroscopy. The structure lacking a bridging group displays ultrafast charge separation (within 2 ps) and charge recombination typical of stacked dyad systems. Structures having one-to-four bridging groups undergo charge separation with decay times of 8-21 ps and charge recombination with decay times of 60-120 ps that are only weakly dependent upon the distance between the pyrene and dimethylaniline capping groups. This behavior is similar to that of wire-like systems having extended conjugated bridges and provides the first example of wire-like behavior in a pi-stacked donor-bridge-acceptor system.

  DOI：

  10.1021/ja073219n
• 作为产物：
  描述：

  芘 在 sodium hydrogen sulfide 、 硝酸 、 溶剂黄146 、 三乙胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 N-甲基-1-芘胺
  参考文献：
  名称：

  RNA修饰的尿苷衍生物作为RNA中潜在的电子供体的制备和表征

  摘要：

  大约20年前首次观察到跨双链DNA的电荷转移，并且此后一直是大量研究的主题。在这方面几乎没有研究过RNA，这至少是由于缺乏适当功能化的核糖核苷酸结构单元以在掺入寡核糖核苷酸中时用作电子源。我们合成了两个带有核碱基C5的py或二甲基氨基py的尿苷衍生物。成功合成的关键是使Suzuki–Miyaura条件适应to部分与核糖核苷的偶联。与标准的5'-的pyrenylated核苷的最终装饰Ø和2'- - Ø保护基团和随后的3' Ø-磷酸化作用为整合入RNA奠定了基础。两种吡啶基化尿苷和相应修饰的寡核苷酸的光谱分析表明，特别是二甲氨基amino官能化的核苷是一种有前途的候选物，可作为RNA电荷转运研究的电子源。

  DOI：

  10.1039/c8ob02246a

文献信息

• Exciplexes
  申请人：——

  公开号：US20030108892A1

  公开（公告）日：2003-06-12

  Compounds capable of forming an intramolecular exciplex on photoirradiation of the compound in water comprise two exciplex forming partners, one being a donor moiety and the other an acceptor moiety, each having at least one aromatic nucleus and being connected by a saturated aliphatic chain having the flexibility to allow said partners to come into exciplex forming relationship. The compounds may be used as labels for oligonucleotides. Certain of the compounds display pH sensitive emission.

  在水中光照条件下能够形成分子内激发态络合物的化合物包括两个激发态络合物形成合作伙伴，一个是给体基团，另一个是受体基团，每个基团至少具有一个芳香环，并通过具有足够柔韧性的饱和脂肪链连接，使这些合作伙伴能够形成激发态络合物关系。这些化合物可用作寡核苷酸的标记。其中一些化合物显示出pH敏感的发射特性。
• Sustainable and Affordable Synthesis of (Deuterated) <i>N</i>-Methyl/Ethyl Amines from Nitroarenes
  作者：Akash Mondal、Abhijith Karattil Suresh、Ganesan Sivakumar、Ekambaram Balaraman

  DOI：10.1021/acs.orglett.2c03595

  日期：2022.12.16

  affordable synthesis of (deuterated) N-methyl/ethyl amines directly from nitroarenes is disclosed. The reaction is catalyzed by a single-site manganese catalyst and involves tandem dehydrogenation, transfer hydrogenation, and borrowing hydrogenation. This catalytic protocol is highly selective and provides a facile method for the large-scale synthesis of a series of N-CH3/N-CD3 aniline derivatives with excellent

  公开了直接从硝基芳烃可持续和负担得起的（氘代）N-甲基/乙基胺的合成。该反应由单中心锰催化剂催化，包括串联脱氢、转移氢化和借位氢化。该催化方案具有高选择性，为大规模合成一系列具有优异官能团耐受性的N -CH 3 / N -CD 3苯胺衍生物提供了一种简便的方法。
• Polymeric charge transfer complexes for nonlinear optical applications
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0402038A2

  公开（公告）日：1990-12-12

  This invention provides an optical medium and a process therefor wherein the medium exhibits third order nonlinear optical response and comprises a polymer with pendant groups having delocalized pi-electron character forming a charge transfer complex with dopant molecules. The optical medium is useful in optical devices, such as optical switches or light modulation devices as a component or as a coating. In other aspects, novel polymers and polymer complexes are disclosed.

  本发明提供了一种光学介质及其加工方法，其中的介质具有三阶非线性光学响应，并包含一种聚合物，该聚合物具有与掺杂分子形成电荷转移复合物的具有脱局域π-电子特性的悬垂基团。这种光学介质可用于光学设备，如作为组件或涂层的光学开关或光调制设备。在其他方面，公开了新型聚合物和聚合物复合物。
• METHOD FOR DETERMINING PROSTATE CANCER
  申请人：The Noguchi Institute

  公开号：EP2354790A1

  公开（公告）日：2011-08-10

  The present invention provides a method for detecting a glycan structure of a prostate specific antigen (PSA) rapidly and with high sensitivity and determining prostate carcinoma based on the difference in the structure, in particular, a method for determining between prostate carcinoma and benign prostatic hyperplasia accurately. A method for determining prostate carcinoma, wherein the method includes a step of analyzing a PSA glycan structure in a sample derived from a test subject, and prostate carcinoma is determinied in the case that amount of a glycan having LacdiNAc (N-acetylgalactosamine-N-acetylglucosamine) (LacdiNAc(+)) is more than 30% of amount of a glycan not having LacdiNAc but having LacNAc (galacotose-N-acetylglucosamine) (LacdiNAc(-)). Especially, a method for determining prostate carcinoma, wherein prostate carcinoma is determinied in the case that amount of a glycan having LacdiNAc (N-acetylgalactosamine-N-acetylglucosamine) (LacdiNAc(+)) is more than 30% of amount of a glycan not having LacdiNAc but having LacNAc (galacotose-N-acetylglucosamine) (LacdiNAc(-)), and benign prostatic hyperplasia is determined in the case of 30% or less.

  本发明提供了一种快速、高灵敏度地检测前列腺特异性抗原（PSA）的聚糖结构并根据该结构的差异判断前列腺癌的方法，特别是一种准确判断前列腺癌和良性前列腺增生的方法。一种确定前列腺癌的方法，其中该方法包括一个步骤，即分析来自测试对象的样本中的 PSA 聚糖结构、如果具有 LacdiNAc（N-乙酰半乳糖胺-N-乙酰葡糖胺）（LacdiNAc(+)）的聚糖的量超过不具有 LacdiNAc 但具有 LacNAc（半乳糖-N-乙酰葡糖胺）（LacdiNAc(-)）的聚糖的量的 30%，则可确定前列腺癌。特别是一种用于确定前列腺癌的方法，其中在具有 LacdiNAc（N-乙酰半乳糖胺-N-乙酰葡糖胺）（LacdiNAc(+)）的聚糖的量超过不具有 LacdiNAc 但具有 LacNAc（半乳糖-N-乙酰葡糖胺）（LacdiNAc(-)）的聚糖的量的 30% 的情况下确定前列腺癌，而在 30% 或以下的情况下确定良性前列腺增生。
• Chromatographic materials for the separation of unsaturated molecules
  申请人：Waters Technologies Corporation

  公开号：US10092894B2

  公开（公告）日：2018-10-09

  The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.

  本公开涉及一种从混合物中分离相关化合物，特别是相关不饱和化合物的方法。使用色谱柱分离化合物，该色谱柱具有用于各种不同色谱模式的色谱固定相材料，其中含有第一取代基和第二取代基。在色谱条件下，第一取代基可最大程度地减少化合物保留时间的变化。第二取代基通过加入一个或多个芳香族、多芳香族、杂环芳香族或多杂环芳香族烃基团（每个基团可选择被脂肪族基团取代），在色谱上选择性地保留化合物。