1,12-Di(imidazol-1-yl)dodecane-1,12-dione | 122236-61-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,12-Di(imidazol-1-yl)dodecane-1,12-dione
• CAS: 122236-61-7
• 化学式: C₁₈H₂₆N₄O₂
• 分子量: 330.43
• InChiKey: IDLZEFGTCHLPHU-UHFFFAOYSA-N

物化性质

• 沸点：
  518.6±56.0 °C(predicted)
• 密度：
  1.13±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  69.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,12-Di(imidazol-1-yl)dodecane-1,12-dione 在 羟胺 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 dodecanodihydroxamic acid
  参考文献：
  名称：

  Conformational behaviour of hydroxamic acids: ab initio and structural studies

  摘要：

  The conformational behaviour of a series of monohydroxamic acids, p-RC(6)H(4)CONR'OH (R = Me, R' = H, Me; R = MeO, R' = H, Me; R = NO2, R' = H), and a series of dihydroxamic acids, (CH2)(n)(CONR'OH)(2) (n = 3-8, 10, R' = H and n = 7, R' = Me), in methanol, DMSO and chloroform and in the solid state has been examined using IR and NMR spectroscopy, X-Ray crystal structure determinations of p-MeC(6)H(4)CONMeOH and the monohydrate of glutarodihydroxamic acid (n = 3) together with ab initio molecular orbital calculations for several hydrated and unhydrated hydroxamic acids have been performed. Hydrogen bonding effects are shown to be important in both the solid state and solution, The cis(Z) conformation of the hydroxamate group(s) (CONHOH) is preferentially stabilized by hydrogen bonding with water molecules.

  DOI：

  10.1039/p29960002673
• 作为产物：
  描述：

  十二烷二酸 、 N,N'-羰基二咪唑 以 neat (no solvent) 为溶剂， 反应 2.0h， 以100%的产率得到1,12-Di(imidazol-1-yl)dodecane-1,12-dione
  参考文献：
  名称：

  机械化学，无溶剂反应合成交联的糖肽和尿素，并通过TEM和X射线晶体学测定其结构性质

  摘要：

  报道了一种在无溶剂条件下合成羰基二咪唑介导的复杂糖肽和脲的高效，经济高效的绿色方法。该反应可以在行星式球磨机中通过干磨方便地进行，并且由此产生的新型糖衍生物的分离可以通过使用环境良性物质的尺寸排阻色谱法非常有效地实现。双丙酮半乳糖基二酰胺结晶后，可通过X射线晶体学检查，发现具有心形结构。尽管基于4-氨基苯基半乳糖苷的二酰胺合成形成了球形颗粒，但通过TEM成像分析，基于丙氨酸的二酰胺形成了纳米丝/管状结构。

  DOI：

  10.1002/cplu.201402185

文献信息

• Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation
  作者：J. William Lown、Krzysztof Krowicki、Jan Balzarini、Robert A. Newman、Erik De Clercq

  DOI：10.1021/jm00130a024

  日期：1989.10

  have been synthesized which are structurally related to the natural antiviral antitumor antibiotics netropsin and distamycin bearing two such moieties linked by polymethylene bridges. Cytostatic activity against both human and murine tumor cell lines and their in vitro activity against a range of viruses are reported. Enhanced antiviral activity was obtained against vaccinia virus. As a result of the

  合成了一组寡肽，其在结构上与天然抗病毒抗肿瘤抗生素netropsin和distamycin有关，带有通过聚亚甲基桥连接的两个这样的部分。据报道，对人和鼠肿瘤细胞系均具有细胞抑制活性，并且它们对多种病毒具有体外活性。获得了针对牛痘病毒的增强的抗病毒活性。由于引入了多亚甲基接头[（CH2）n，n = 1、2和6-8]，与母体化合物netropsin和distamycin相比，其抗肿瘤和抗痘苗病毒的活性均显着增强。讨论了这些试剂的生物学活性，既涉及其结构差异，也涉及其与双链DNA的小沟结合。
• Cured film and method for producing same
  申请人：TORAY INDUSTRIES, INC.

  公开号：US10908500B2

  公开（公告）日：2021-02-02

  Provided is a cured film having high chemical resistance, high elongation, and high adhesion to metal copper. A cured film formed by curing a photosensitive resin composition containing a polybenzoxazole precursor, in which a rate at which the polybenzoxazole precursor is cyclized into polybenzoxazole is not less than 10% and not more than 60%.

  本发明提供了一种具有高耐化学腐蚀性、高伸长率以及与金属铜的高粘合性的固化膜。通过固化含有聚苯并恶唑前体的光敏树脂组合物而形成的固化膜，其中聚苯并恶唑前体环化成聚苯并恶唑的速率不低于 10%，不高于 60%。
• Alkali-soluble resin, photosensitive resin composition, photosensitive sheet, cured film, interlayer insulating film or semiconductor protective film, production method for relief pattern of cured film, and electronic component or semiconductor device
  申请人：TORAY INDUSTRIES, INC.

  公开号：US11279802B2

  公开（公告）日：2022-03-22

  The present invention provides an alkali-soluble resin with which a cured film having high extensibility, reduced stress, high adhesion to a metal, and high heat resistance can be obtained, and a photosensitive resin composition containing the alkali-soluble resin, and the present invention is an alkali-soluble resin (A) including a structure represented by a general formula (1) wherein X1 represents a divalent organic group having 2 to 100 carbon atoms, Y1 and Y2 each represent a divalent to hexavalent organic group having 2 to 100 carbon atoms, X2 represents a tetravalent organic group having 2 to 100 carbon atoms, p and q each represent an integer in a range of 0 to 4, and n1 and n2 each represent an integer in a range of 5 to 100,000, wherein (I) and (II) described below are satisfied: (I) an organic group having an aliphatic chain having 8 to 30 carbon atoms is contained as X1 of the general formula (1) at a content of 30 to 70 mol % based on 100 mol % of a total of X1 and X2, and (II) an organic group having a diphenyl ether structure is contained as Y1 of the general formula (1) at a content of 1 to 30 mol % based on 100 mol % of a total of Y1 and Y2.

  本发明提供了一种碱溶性树脂，利用其可以获得具有高延伸性、低应力、对金属的高附着力以及高耐热性的固化膜，并提供含有该碱溶性树脂的光敏树脂组合物。本发明的碱溶性树脂(A)包含由通式(1)表示的结构，其中X1表示具有2至100个碳原子的二价有机基团，Y1和Y2各自表示具有2至100个碳原子的二价至六价有机基团，X2表示具有2至100个碳原子的四价有机基团，p和q各自表示0至4之间的整数，n1和n2各自表示5至100,000之间的整数，并且满足以下(I)和(II)条件： (I) 在通式(1)中，作为X1的含有具有8至30个碳原子的脂肪链的有机基团的含量基于X1和X2的总量为30至70摩尔%； (II) 在通式(1)中，作为Y1的含有二苯醚结构的有机基团的含量基于Y1和Y2的总量为1至30摩尔%。
• Interstrand DNA cross-linking with dimers of the spirocyclopropyl alkylating moiety of CC-1065
  作者：Mark A. Mitchell、Paul D. Johnson、Marta G. Williams、Paul A. Aristoff

  DOI：10.1021/ja00198a068

  日期：1989.8
• Brown, D. A.; Geraty, R. A.; Glennon, J. D., Synthetic Communications, 1985, vol. 15, # 13, p. 1159 - 1164
  作者：Brown, D. A.、Geraty, R. A.、Glennon, J. D.、Choileain, N. Ni

  DOI：——

  日期：——