1-菲-1-基乙酮 | 5968-48-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 1-菲-1-基乙酮
• 英文名称: 1-Phenanthren-1-yl-ethanone
• 英文别名: 1-acetylphenanthrene；1-[1]phenanthryl-ethanone；1-[1]Phenanthryl-aethanon；1-(Phenanthryl-(2))-aethanon-(1)；1-(Phenanthren-1-yl)ethanone；1-phenanthren-1-ylethanone
• CAS: 5968-48-9
• 化学式: C₁₆H₁₂O
• 分子量: 220.271
• InChiKey: FFNRKAWQIXXMNB-UHFFFAOYSA-N

物化性质

• 熔点：
  112-113 °C
• 沸点：
  405.9±14.0 °C(Predicted)
• 密度：
  1.164±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-菲-1-基乙酮 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 9,10-二氧代-9,10-二氢-2-菲羧酸
  参考文献：
  名称：

  Langenbeck; Schaller; Arneberg, Chemische Berichte, 1942, vol. 75, p. 1483,1487

  摘要：

  DOI：
• 作为产物：
  描述：

  1-[1]菲基-乙醇 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 1-菲-1-基乙酮
  参考文献：
  名称：

  Nurses' representations of the perceived causes of work-related stress: A network drawing approach

  摘要：

  DOI：

  10.1080/02678370120688

文献信息

• Exploiting Aryl Mesylates and Tosylates in Catalytic Mono-α-arylation of Aryl- and Heteroarylketones
  作者：Wai Chung Fu、Chau Ming So、On Ying Yuen、Irene Toi Chuk Lee、Fuk Yee Kwong

  DOI：10.1021/acs.orglett.6b00643

  日期：2016.4.15

  The first general palladium catalyst for the catalytic mono-α-arylation of aryl- and heteroarylketones with aryl mesylates and tosylates is described. The newly developed indolyl-derived phosphine ligand L7 has been identified to promote this reaction efficiently. The key to success is attributed to the enhanced steric congestion of the catalyst and effective oxidative addition of the C(Ar)–OMs bond

  描述了用于芳基-和杂芳基酮与甲磺酸甲磺酸酯和甲苯磺酸酯的催化单-α-芳基化的第一种通用钯催化剂。已经确定了新开发的吲哚基衍生的膦配体L7可以有效地促进该反应。成功的关键归因于催化剂空间拥堵的增强和C （Ar） –OMs键的有效氧化加成。在Pd（OAc）2（0.25-2.5 mol％）和L7的存在下，选择性单芳基化反应可在足够的反应范围内实现，并且产物收率高达95％。重要的是，我们证明了该协议对生物酚类化合物的修饰的适用性，使其可用于酚类（前）药物的功能化。
• Cyclic peptide structures for molecular scale electronic and photonic devices
  申请人：——

  公开号：US20030144185A1

  公开（公告）日：2003-07-31

  The present invention discloses a family of cyclic peptide monomers and supramolecular cyclic peptide structures comprising chromophore residues which possess electronic and electro-optic properties for producing molecular scale electronic and photonic devices made from such materials. More particularly, this invention provides for cyclic peptide nanotube structures formed from a plurality of stacked cyclic peptides comprising chromophore residues that provide molecular scale electronic conductivity and non linear optical behavior. The stackable cyclic peptide is represented by the general formula 1 wherein R 1 is H, CH 3 or alkyl; wherein R 2 a chromophore or a rigid and flat extended conjugated pi system other than benzene; wherein R 3 is H, CH 3 or a polar or non-polar organic functional group used for controlling peptide stacking and solubility; wherein n equals 1 or 2; wherein m equals 4 or 6; and wherein a first adjacent amino acid residue has an &agr;-carbon chirality of L and a second adjacent amino acid residue has an &agr;-carbon chirality of D.

  本发明揭示了一系列环肽单体和超分子环肽结构，包括具有电子和电光性能的色团残基，用于制造由此类材料制成的分子尺度电子和光子器件。更具体地，本发明提供了由多个堆叠的环肽组成的环肽纳米管结构，其中包括提供分子尺度电导和非线性光学行为的色团残基。可堆叠的环肽由通式1表示，其中R1为H、CH3或烷基；R2为色团或刚性和扁平的扩展共轭π体系，而非苯；R3为H、 或用于控制肽堆叠和溶解度的极性或非极性有机功能基团；n等于1或2；m等于4或6；第一个相邻氨基酸残基具有L的α-碳手性，第二个相邻氨基酸残基具有D的α-碳手性。
• Preparation and photophysical properties of fluorescent difluoroboronated β-diketones having phenanthrene moieties studied by emission and transient absorption measurements
  作者：Michitaka Mamiya、Yurie Suwa、Hideki Okamoto、Minoru Yamaji

  DOI：10.1039/c5pp00454c

  日期：2016.2

  largest fluorescence quantum yield (0.81) in acetonitrile among the Phe@Ars whereas 2-Phe@Ph having the 2-phenanthryl moiety shows the smallest fluorescence quantum yield (0.07) in acetonitrile. All the Phe@Ars show fluorescence also in the solid state, and the fluorescence spectra and quantum yields were determined. Transient absorption measurement using laser flash photolysis of the Phe@Ars revealed

  制备六个具有菲骨架（Phe @ Ar）的二氟硼化的β-二酮。根据荧光量子产率，寿命和瞬态吸收的测量结果，与具有苯基，萘基和蒽基的二氟硼化二酮相比，研究了Phe @ Ar的光物理特征。制备具有1-，2-，3-和9-菲基部分（PheDKAr）的β-二酮作为Phe @ Ar的前体。通过光环化方法合成了1-乙酰基菲，作为具有1-菲基部分的PheDKAr的关键结构单元。制备的PheDKAr的反芳族部分（Ar）随苯基，呋喃基和噻吩基环（分别为Ar = Ph，F和T）变化，以研究π共轭对荧光性质的影响。所制备的Phe @ Ars是发荧光的，具有可观的荧光量子产率，这取决于菲部分的取代位置。具有3-菲基的3-Phe @ Ph在乙腈中提供最大的乙腈荧光量子产率（0.81），而具有2-菲基的2-Phe @ Ph在乙腈中显示最小的荧光量子产率（0.07） 。所有的Phe @ Ars都在固态时也显示荧光，并确定了荧光光谱和量子产率。使用Phe
• Cyclic peptide nanotube structures for molecular scale electronic and photonic devices
  申请人：McGimpsey Grant William

  公开号：US20050124535A1

  公开（公告）日：2005-06-09

  The present invention discloses a family of cyclic peptide monomers and supramolecular cyclic peptide structures comprising chromophore residues which possess electronic and electro-optic properties for producing molecular scale electronic and photonic devices made from such materials. More particularly, this invention provides for cyclic peptide nanotube structures formed from a plurality of stacked cyclic peptides comprising chromophore residues that provide molecular scale electronic conductivity and non linear optical behavior. The stackable cyclic peptide is represented by the general formula of m repeating amino acid residue pairs where n equals 1 or 2, m equals 4 or 6, R A and R D are either H, CH 3 or an alkyl, where at least one R B or R E in at least one repeating residue pair is a chromophore, where R C and R F are either H, CH 3 or a polar or non-polar organic functional group used for controlling peptide stacking, nanotube formation and solubility, and where a first adjacent amino acid residue has an α-carbon chirality of L and a second adjacent amino acid residue has an α-carbon chirality of D.

  本发明披露了一类环肽单体和超分子环肽结构，包括具有电子和电光性质的色团残基，用于制备由此类材料制成的分子尺度电子和光子器件。更具体地，本发明提供了由多个堆叠的含有色团残基的环肽组成的环肽纳米管结构，其提供了分子尺度的电子传导和非线性光学行为。可堆叠的环肽由m个重复的氨基酸残基对表示，其中n等于1或2，m等于4或6，RA和RD为H、CH3或烷基，其中至少一个重复残基对中的RB或RE为色团，RC和RF为H、 或用于控制肽堆叠、纳米管形成和溶解度的极性或非极性有机功能基团，其中第一个相邻氨基酸残基具有Lα-碳手性，第二个相邻氨基酸残基具有Dα-碳手性。
• Visible-Light Photoredox-Catalyzed Decarboxylation of α-Oxo Carboxylic Acids to C1-Deuterated Aldehydes and Aldehydes
  作者：Chun-Hong Hu、Yang Li

  DOI：10.1021/acs.joc.2c02299

  日期：——

  deuterated lead compounds for deuterium-labeled drug discovery. Herein, we develop a metal-free synthesis of C1-deuterated aldehydes with D2O from α-oxo carboxylic acids at ambient temperature. Via visible-light photoredox-catalyzed decarboxylation, stoichiometric reductants and oxidants were avoided. Various functional groups were tolerated and resulted in C1-deuterium aldehydes in up to 92% yield

  高附加值的 C1-氘代醛的合成将提高用于氘标记药物发现的氘化先导化合物的可用性。在此，我们开发了一种在环境温度下从 α-氧代羧酸中用 D 2 O无金属合成 C1-氘代醛的方法。通过可见光光氧化还原催化脱羧，避免了化学计量的还原剂和氧化剂。可以耐受各种官能团，并在温和条件下以高达 92% 的产率和 91-97% 的 D 掺入率产生 C1-氘醛。该方法也适用于各种醛的合成。主要机理研究表明，催化途径通过还原猝灭途径发生，然后是氢原子转移。