9,10-二氧代-9,10-二氢-2-菲羧酸 | 32060-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 9,10-二氧代-9,10-二氢-2-菲羧酸
• 英文名称: 9,10-dioxo-9,10-dihydro-phenanthrene-2-carboxylic acid
• 英文别名: 9,10-Dioxo-9,10-dihydro-phenanthren-2-carbonsaeure；Phenanthrenchinon-carbonsaeure-(2)；9,10-Dioxo-9,10-dihydrophenanthrene-2-carboxylic acid；9,10-dioxophenanthrene-2-carboxylic acid
• CAS: 32060-67-6
• 化学式: C₁₅H₈O₄
• 分子量: 252.226
• InChiKey: BYWOUGDCDOALSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2918300090

反应信息

• 作为反应物：
  描述：

  9,10-二氧代-9,10-二氢-2-菲羧酸 在 4-二甲氨基吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 [(9,10-Dioxo-9,10-dihydro-phenanthrene-2-carbonyl)-amino]-acetic acid
  参考文献：
  名称：

  Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45

  摘要：

  The cytosolic portion of CD45, a major transmembrane glycoprotein found on nucleated hematopoietic cells, contains protein tyrosine phosphatase activity and is critical for T-cell receptor-mediated T-cell activation. CD45 inhibitors could have utility in the treatment of autoimmune disorders and organ graft rejection. A number of 9, l0-phenanthrenediones were identified that reversibly inhibited CD45-mediated p-nitrophenyl phosphate (pNPP) hydrolysis. Chemistry efforts around the 9,10-phenanthrenedione core led to the most potent inhibitors known to date. In a functional assay, the compounds were also potent inhibitors of T-cell receptor-mediated proliferation, with activities in the low micromolar range paralleling their enzyme inhibition. It was also discovered that the nature of modification to the phenanthrenedione pharmacophore could affect selectivity for CD45 over PTP1B (protein tyrosine phosphatase 1B) or vice versa.

  DOI：

  10.1021/jm000447i
• 作为产物：
  描述：

  2-菲甲酸 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 9,10-二氧代-9,10-二氢-2-菲羧酸
  参考文献：
  名称：

  Werner; Ney, Justus Liebigs Annalen der Chemie, 1902, vol. 321, p. 356

  摘要：

  DOI：

文献信息

• Cd45 inhibitors
  申请人：——

  公开号：US20030207812A1

  公开（公告）日：2003-11-06

  Substituted phenanthrene-9,10-diones in accord with structural diagram I, 1 compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R 1 at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH 2 , NO 2 , NH—CO—R 2 , CO—NH—R 2 , Ar, (CH 2 ) n CH(COOH)R 3 COR 3 and NHCOCH 2 CH(COOH)NHR 4 , where R 2 , R 3 and R 4 are a selected from a variety of substituted or unsubstituted alkyl and aryl groupstand oligopeptides.

  根据结构图I，以及其中的苯并蒽-9,10-二酮，其组成物和使用方法，用于治疗T细胞介导的情况，如自身免疫疾病和器官移植排斥。在本发明的化合物中，每个出现的R1独立地选自氢、卤素、NH-对甲苯磺酰基、N-二对甲苯磺酰基、NH2、NO2、NH-CO-R2、CO-NH-R2、Ar、(CH2)nCH(COOH)R3COR3和NHCOCH2CH(COOH)NHR4，其中R2、R3和R4选自各种取代或未取代的烷基和芳基以及寡肽。
• [EN] COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS<br/>[FR] COMPOSITIONS ET MÉTHODES DE PRODUCTION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES EXPANSÉES À L'AIDE D'INHIBITEURS DE PTEN
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2018217567A1

  公开（公告）日：2018-11-29

  This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from sources of non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

  本发明涉及一些方面，包括用于维持、增强和扩展非动员周围血源造血干细胞的化合物、方法、系统和组合物。本文还提供了一些公式I的化合物，这些化合物可用于维持、增强和扩展造血干细胞。
• SENSOR AND CONCENTRATION MEASUREMENT METHOD
  申请人：Panasonic Corporation

  公开号：EP2474825A1

  公开（公告）日：2012-07-11

  A reagent layer (4) of a sensor (1) contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor 1.

  传感器（1）的试剂层（4）含有一种具有亲水官能团的醌化合物、菲醌和/或菲醌衍生物作为介质。醌化合物的氧化还原电位比传统介质低，因此干扰物质对传感器 1 检测结果的影响较小。
• REAGENT COMPOSITION, SENSOR, SENSOR SYSTEM, AND SENSOR MANUFACTURE PROCESS
  申请人：Panasonic Corporation

  公开号：EP2623974A1

  公开（公告）日：2013-08-07

  The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.

  本发明提供：一种具有更高贮存稳定性的试剂组合物；一种涉及该试剂组合物的传感器；以及其他。根据本发明，在试剂组合物中添加特定的杂环化合物，以提高试剂组合物的储存稳定性，并降低使用试剂组合物的传感器中电流值的波动程度。
• SENSOR
  申请人：Panasonic Healthcare Holdings Co., Ltd.

  公开号：EP3343213A2

  公开（公告）日：2018-07-04

  The present invention provides a sensor for detecting or quantifying a target substance contained in a liquid sample. The sensor comprises a quinone compound that accepts electrons released as a result of dehydrogenation or oxidization of the target substance by the enzyme; and at least a pair of electrodes, wherein the quinone compound contains a quinone and a substituent, wherein the substituent is hydrophilic. The quinone compound has a lower redox potential than conventional substances, so interfering substances have less effect on detection results with this sensor, particularly the redox potential of the quinone compound measured using a silver/silver chloride (saturated potassium chloride) electrode as a reference electrode is more negative than the oxidization potential of ascorbic acid.

  本发明提供了一种用于检测或量化液体样品中所含目标物质的传感器。该传感器由醌化合物和至少一对电极组成，其中醌化合物含有醌和取代基，取代基为亲水性。醌化合物的氧化还原电位低于传统物质，因此干扰物质对该传感器检测结果的影响较小，特别是使用银/氯化银（饱和氯化钾）电极作为参比电极测量的醌化合物的氧化还原电位比抗坏血酸的氧化电位更负。