butoxide anion | 26232-84-8

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: butoxide anion
• 英文别名: butan-1-ol; deprotonated form；Butan-1-olate
• CAS: 26232-84-8
• 化学式: C₄H₉O
• 分子量: 73.1149
• InChiKey: DGKBAVXKKOKWSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  5
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  butoxide anion 生成 n-butyraldehyde enolate 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Mercer, Roger S.; Harrison, Alex G., Canadian Journal of Chemistry, 1988, vol. 66, p. 2947 - 2953

  摘要：

  DOI：
• 作为产物：
  描述：

  正丁醇 生成 butoxide anion
  参考文献：
  名称：

  Gas-Phase Acidity of Aliphatic Alcohols

  摘要：

  DOI：

  10.1021/ja00346a600
• 作为试剂：
  描述：

  4,4-dichloro-3-phenyl-2-cyclobuten-1-one 在 butoxide anion 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.25h， 生成 Butyl 4,4-dichloro-3-phenyl-3-butenoate
  参考文献：
  名称：

  Cycloaddition. 30. Synthesis, regiochemistry, and reactions of dichlorocyclobutenones

  摘要：

  DOI：

  10.1021/jo00168a003

文献信息

• A Three-Step Protocol towards N-8-(2,2-Dimethoxyethyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one
  作者：Kevin Blades、Steven Glossop

  DOI：10.1055/s-0036-1588364

  日期：——

  Abstract An efficient high-yielding three-step synthesis of N-8-(2,2-dimethoxyethyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one is reported. The route utilises a Heck coupling as the key step. An efficient high-yielding three-step synthesis of N-8-(2,2-dimethoxyethyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one is reported. The route utilises a Heck coupling as the key step.

  摘要 报道了N -8-（2,2-二甲氧基乙基）-2-甲基磺酰胺基吡喃并[2,3 - d ]嘧啶-7-one的高效高产三步合成法。该路线利用Heck耦合作为关键步骤。 报道了N -8-（2,2-二甲氧基乙基）-2-甲基磺酰胺基吡喃并[2,3 - d ]嘧啶-7-one的高效高产三步合成法。该路线利用Heck耦合作为关键步骤。
• Dehydrogenation of Alcohols and Hydrocarbons by Atomic Metal Anions
  作者：Jaleh Halvachizadeh、Alex Mungham、Paul M. Mayer

  DOI：10.1255/ejms.1305

  日期：2015.6

  The reactivity of anionic metal–carbonyl systems toward hydrocarbons, alcohols, and a variety of other classes of molecules is well established in the literature. In this study we explored the reactions of atomic metal anions M⁻, notably K⁻, Cs⁻, Co⁻, Fe⁻, Cu⁻, and Ag⁻, with alcohols, alkanes, alkenes, and alkynes. All of the metal anions deprotonated the alcohols and alkynes. Also observed were the subsequent reactions of the resulting organic anions. Fe⁻ and Cu⁻ consistently displayed mono- and bis-dehydrogenation of primary and secondary alcohols, and alkanes, alkenes, and alkynes to form MH⁻ and MH₂⁻. Mechanisms for the dehydrogenation reactions are proposed and substantiated with isotopically-labelled reagents and thermochemical arguments.

  阴离子金属-羰基体系对烃、醇和其他分子类别的反应性在文献中得到了充分的证实。在本研究中，我们探讨了原子金属阴离子M^-（尤其是K^-、Cs^-、Co^-、Fe^-、Cu^-和Ag^-）与醇、烷烃、烯烃和炔烃的反应。所有金属阴离子都去质子化了醇和炔烃。观察到了产生的有机阴离子的后续反应。Fe^-和Cu^-一致地表现出一次和二次醇、烷烃、烯烃和炔烃的单和双脱氢反应，形成MH^-和MH₂^-。提出了脱氢反应的机理，并用同位素标记试剂和热化学论据加以证实。
• 12-hetero substituted 6,11-ethano-6,11-dihydrobenzo (b) quinolizinium
  申请人：Sterling Winthrop Inc.

  公开号：US05380729A1

  公开（公告）日：1995-01-10

  1-Hetero substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

  1-含有杂原子取代的6,11-乙烷-6,11-二氢苯并[b]喹啉盐，含有它们的制药组合物，以及利用它们治疗或预防神经退行性疾病或神经毒性损伤的方法。
• Derivatives of thioformamide
  申请人：Rhone-Poulenc Sante

  公开号：US05151436A1

  公开（公告）日：1992-09-29

  Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C.dbd.NOR.sup.1, >C.dbd.NN(R.sup.1).sub.2 or >C.dbd.NN(R.sup.1)CON(R.sup.1).sub.2 in which R.sup.1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R.sup.1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.

  本发明涉及一种治疗上有用的硫代甲酰胺衍生物，其化学式为：##STR1## 其中，R代表烷基，Het代表吡啶-3-基，异喹啉-4-基，四氢喹啉-3-基，喹啉-3-基，吡嗪-4-基，嘧啶-5-基，噻唑-5-基，噻吩[2,3-b]-吡啶-5-基，吡嗪-2-基，吲哚-3-基和噻吩[3,2-b]-吡啶-6-基，Y代表乙烯基，亚甲基或一个价键，X代表羰基，羟甲亚基，>C.dbd.NOR.sup.1，>C.dbd.NN(R.sup.1).sub.2或>C.dbd.NN(R.sup.1)CON(R.sup.1).sub.2，其中R.sup.1代表氢或可选取代的烷基，苯甲基，苯乙基，1-萘甲基，2-萘甲基或吡啶-3-甲基，或者同一氮原子上的两个R.sup.1取代基可共同形成一个可选取代的烷基链，以及其盐，其制备方法和含有它们的组合物。
• 3-Hydroxy-3-(1,2,5-thiadiazolyloxyalkanol)-3,4-dihydro-2H-1,5-ben
  申请人：Merck & Co., Inc.

  公开号：US03944560A1

  公开（公告）日：1976-03-16

  3-Hydroxy-3-(substituted-aminoalkyl-3,4-dihydro-2H-1,5-benzodioxepin products are described that exhibit .sym.-advenergic stimulating properties and are therefore suitable for use as bronchodilating agents. The products are prepared essentially by four principal routes from 3-oxo-3,4-dihydro-2H-1,5-benzodioxepins. By one route the 3-oxobenzodioxepin is treated with a nitroalkane to give a 3-hydroxy-3-nitroalkyl-benzodioxepin the nitro group of which is reduced to an amine and the resulting compound reacted with an aldehyde or ketone under hydrogenating conditions to introduce the desired substituent into the amino function. By a second route the 3-oxobenzodioxepin is reacted with an alkali metal nitrile to form the cyanhydrin which upon reduction forms the 3-hydroxy-3-aminoalkyl-benzodioxepin that can be treated with a ketone or aldehyde to give the desired products or can be reacted with sodium nitrite or other agent to form a 3-spiro-benzodioxepin-2-oxirane which upon reaction with an amine provides the desired product. The 3-spiro-benzodioxepin-2'-oxirane also can be obtained by treatment of the 3-oxo-benzodioxepin with a sulfurylide, A fourth method involves forming a benzodioxepin-3-spiro-5'-oxazolidin-2'-one which upon treatment with dilute alkali gives the desired 3-hydroxy-3-(substituted aminoalkyl)-3,4-dihydro-2H-1,5-benzodioxepin The intermediate oxazolidinone compounds can be treated if desired with various agents to attach substituents on the benzenoid moiety of the starting substance. These oxazolidinones exhibit .beta. -stimulating and skeletal muscle relaxant properties.

  描述了具有β-肾上腺素能兴奋作用的3-羟基-3-(取代氨基烷基)-3,4-二氢-2H-1,5-苯并二氧杂环庚烷产品，因此适用于用作支气管扩张剂。这些产品基本上通过从3-氧代-3,4-二氢-2H-1,5-苯并二氧杂环庚烷经四种主要途径制备而成。其中一种途径是将3-氧代苯并二氧杂环庚烷与硝基烷反应，得到3-羟基-3-硝基烷基苯并二氧杂环庚烷，其硝基还原为胺基，然后在氢化条件下将所得化合物与醛或酮反应，以引入所需的取代基到氨基功能中。第二个途径是将3-氧代苯并二氧杂环庚烷与碱金属腈反应，形成氰水合物，还原后形成3-羟基-3-氨基烷基苯并二氧杂环庚烷，可以用酮或醛处理以得到所需的产物，或者可以与亚硝酸钠或其他试剂反应形成3-螺-苯并二氧杂环庚烷-2-环氧烷，再与胺反应以提供所需的产物。也可以通过用磺酰亚胺处理3-氧代苯并二氧杂环庚烷来获得3-螺-苯并二氧杂环庚烷-2'-环氧烷。第四种方法涉及形成苯并二氧杂环庚烷-3-螺-5'-噁唑烷-2'-酮，该化合物在稀碱处理下可得到所需的3-羟基-3-(取代氨基烷基)-3,4-二氢-2H-1,5-苯并二氧杂环庚烷。如果需要，在中间噁唑烷酮化合物上可以用各种试剂处理以在起始物质的苯环部分附加取代基。这些噁唑烷酮化合物表现出β-肾上腺素能兴奋和骨骼肌松弛作用。