Boc-glycine potassium salt | 62007-87-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-glycine potassium salt
• 英文别名: Potassium;2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• CAS: 62007-87-8
• 化学式: C₇H₁₂NO₄*K
• 分子量: 213.275
• InChiKey: SUWRUSPZFKPHMQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.73
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  11β,17α-dihydroxy-21-iodopregn-4-ene-3,20-dione 、 Boc-glycine potassium salt 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 21-(N-tert-butyloxycarbonyl)aminoacetoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione
  参考文献：
  名称：

  Synthesis of 21-esters of hydrocortisone with glycine and glutamic acid and study of their pharmacological activity

  摘要：

  DOI：

  10.1007/bf00771698
• 作为产物：
  描述：

  BOC-甘氨酸 生成 Boc-glycine potassium salt
  参考文献：
  名称：

  KULIKOV, S. V.;SOKOLOVA, N. YU.;LEONOVA, E. B.;SAMARTSEV, M. A., BIOORGAN. XIMIYA, 15,(1989) N, S. 348-353

  摘要：

  DOI：

文献信息

• 尼莫地平水溶性衍生物及其制备方法和应用
  申请人：广州市恒诺康医药科技有限公司

  公开号：CN105669532B

  公开（公告）日：2018-11-02

  本发明公开了一种尼莫地平水溶性衍生物及其制备方法和应用，属于药物化学技术领域。该类尼莫地平水溶性衍生物具有通式I结构特征，具有较高水溶性，在血液中或体内能通过内在的酶转化成尼莫地平，故这类尼莫地平水溶性衍生物可作为尼莫地平前药，作为钙离子拮抗剂，用于心脑血管疾病治疗。
• Photodecarboxylative additions of N-protected α-amino acids to N-methylphthalimide
  作者：Sonia Gallagher、Fadi Hatoum、Nicolai Zientek、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2010.05.020

  日期：2010.7

  Photoreactions involving N,N-dimethylated α-amino acid salts and N-methylphthalimide are dominated by photoreduction and acetone trapping. Only, N-phenyl glycinate underwent photodecarboxylative addition in a moderate yield of 30%. In contrast, N-acylated α-amino acid salts readily gave addition products in fair to high yields of 20–95%. Comparison experiments with N,N-dimethylacetamide and amino-/amido-containing

  涉及N，N-二甲基化α-氨基酸盐和N-甲基邻苯二甲酰亚胺的光反应以光还原和丙酮捕获为主导。仅甘氨酸N-苯基酯以30％的中等收率进行光脱羧。相反，N-酰化的α-氨基酸盐可以很容易地以20-95％的高至中等收率获得加成产物。与N，N-二甲基乙酰胺和含氨基/氨基的邻苯二甲酰亚胺的对比实验揭示了关键的电子转移步骤的起源和反应顺序NR 3  » RCO2个-- ⩾RCONR 2成立。
• Asymmetric synthesis of bicyclic α-amino acids by a Diels–Alder reaction to a new chiral α,β-didehydroalanine derivative
  作者：Rafael Chinchilla、Larry R Falvello、Nuria Galindo、Carmen Nájera

  DOI：10.1016/s0957-4166(99)00061-0

  日期：1999.3

  A new chiral cyclic alpha,beta-didehydroalanine derivative, (6S)-6-isopropyl-3-methylene-5-phenyl-3,6,dihydro-2H-1,4-oxazin-2-one, has been prepared by in situ aminomethylation-elimination of a chiral glycine-derived precursor. This oxazin-2-one acts as a reactive dienophile ire highly diastereoselective Diels-Alder reactions with cyclopenta- and cyclohexadiene. The major cycloadducts have been isolated and hydrolyzed to afford enantiomerically pure (-)-endo-2-aminobicyclo[2.2.1]heptane-2- and exo-2-aminobicyclo[2.2.2]octane-2-carboxylic acids. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Bimane cyclic esters, possible stereologues of trypanothione as antitrypanosomal agents. Bimanes 29
  作者：EM Kosower、AE Radkowsky、AH Fairlamb、SL Croft、RA Neal

  DOI：10.1016/0223-5234(96)88283-3

  日期：1995.1

  Tricyclic esters derived from bimanes have been synthesized with ring sizes near or equal to that of trypanothione disulfide (T(S)(2)), a bis-glutathionylspermidine that is involved in regulating the thiol status of Leishmania and other trypanosomatids. Modest activity for many of the compounds against Leishmania donovani with a maximum at the T(S)(2) ring size suggests that the esters act as T(S)(2) surrogates. However, no inhibition of T(S)(2)-reductase is observed for a number of the compounds. A series of tricyclic bimane amides with structures more closely analogous to T(S)2 are inactive in biological tests, New approaches were developed for the synthesis of the amides. The surprising effectiveness of the cyclic ester synthesis is explained. Acid chloride formation catalyzed by sulfides is briefly described.
• Synthesis and pharmacological activity of 21-esters of prednisolone with glycine and glutamic acid
  作者：M. I. Ryakhovskaya、G. S. Grinenko、L. M. Alekseeva、G. N. Engalycheva、V. B. Nikitin、M. É. Kaminka、R. G. Glushkov

  DOI：10.1007/bf00772101

  日期：1991.4