N-cyano-4,4'-acetamidodiphenyl sulfoximine | 1420294-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyano-4,4'-acetamidodiphenyl sulfoximine
• 英文别名: N-[4-[S-(4-acetamidophenyl)-N-cyanosulfonimidoyl]phenyl]acetamide
• CAS: 1420294-95-6
• 化学式: C₁₇H₁₆N₄O₃S
• 分子量: 356.405
• InChiKey: MVNDMKLEUOPANT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-cyano-4,4'-acetamidodiphenyl sulfoximine 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以85%的产率得到4,4'-diaminodiphenyl sulfoximine
  参考文献：
  名称：

  Sulfoximine- and Sulfilimine-Based DAPSON Analogues; Syntheses and Bioactivities

  摘要：

  Sulfoximine- and sulfilimine-based diamino-diphenyl sulfone (DAPSON) analogues have been prepared and their COX-1 and COX-2 inhibition potencies as well as LTB4 and TNF binding properties were studied. Furthermore, their antiproliferative activities on cancer cell growth were investigated. Neither compounds showed significant bioactivities.

  DOI：

  10.1055/s-0032-1317493
• 作为产物：
  描述：

  4,4-二氨基二苯硫醚 在 碘苯二乙酸 、 potassium carbonate 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 N-cyano-4,4'-acetamidodiphenyl sulfoximine
  参考文献：
  名称：

  Sulfoximine- and Sulfilimine-Based DAPSON Analogues; Syntheses and Bioactivities

  摘要：

  Sulfoximine- and sulfilimine-based diamino-diphenyl sulfone (DAPSON) analogues have been prepared and their COX-1 and COX-2 inhibition potencies as well as LTB4 and TNF binding properties were studied. Furthermore, their antiproliferative activities on cancer cell growth were investigated. Neither compounds showed significant bioactivities.

  DOI：

  10.1055/s-0032-1317493