3-Pentylthiopropanoic acid | 59358-12-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Pentylthiopropanoic acid
• 英文别名: 3-Amylthiopropionsaeure；3-(Pentylsulfanyl)propanoic acid；3-pentylsulfanylpropanoic acid
• CAS: 59358-12-2
• 化学式: C₈H₁₆O₂S
• 分子量: 176.28
• InChiKey: GHSWLGUUCRYSIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Pentylthiopropanoic acid 在 双氧水 作用下， 以 乙酸酐 、 溶剂黄146 为溶剂， 生成 3-Amylsulfonylpropionsaeure
  参考文献：
  名称：

  Lapkin,I.I.; Fotin,V.V., Journal of Organic Chemistry USSR (English Translation), 1976, vol. 12, p. 529 - 532

  摘要：

  DOI：
• 作为产物：
  描述：

  (chloromethyl)(pentyl)sulfane 生成 3-Pentylthiopropanoic acid
  参考文献：
  名称：

  Lapkin,I.I.; Fotin,V.V., Journal of Organic Chemistry USSR (English Translation), 1976, vol. 12, p. 529 - 532

  摘要：

  DOI：

文献信息

• Carbothiolation of Styrenes by Visible‐Light‐Induced Thiyl Radicals: C3‐Functionalization of Benzofuran‐2(3 <i>H</i> )‐ones
  作者：Dailin Xi、Cong Lu、Dong Jing、Ke Zheng

  DOI：10.1002/ejoc.202200688

  日期：2022.8.12

  A three-component coupling reaction based on the novel precursor of thiyl radical was developed for constructing structurally valuable sulfur-containing 3,3-disubstituted benzofuran-2(3H)-one derivatives. The system is driven by EDA complex assembled between substrates, which means thiyl radical can be generated without external assistance, significantly highlighting the efficiency of this methodology

  开发了一种基于新型硫自由基前体的三组分偶联反应，用于构建具有结构价值的含硫 3,3-二取代苯并呋喃-2(3 H )-酮衍生物。该系统由组装在基板之间的 EDA 复合物驱动，这意味着可以在没有外部帮助的情况下生成硫自由基，显着突出了该方法的效率。
• Guaiacol esters of alpha- and beta-mercaptopropionylalanine and alpha- and beta-mercaptopropionylglycine, process for their preparation and pharmaceutical compositions containing same
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0013261A1

  公开（公告）日：1980-07-09

  Gualacol esters of alpha- and beta-mercaptopropionyl alanine and of alpha- and beta-mercaptopropionyl glycine having formulae: wherein R is hydrogen or methyl and Y is hydrogen or an acyl radical (acetyl, benzoyl or methoxycarbonyl). Pharmaceutical compositions containing these guaiacol esters have mucolytic activity. The process for manufacturing these guaiacol esters comprises preparing in a known per se manner a sulhydryl group-containing intermediate wherein the sulfhydryl is protected by a trityl or p-methoxybenzyl group, and removing the protective group under acid conditions.

  α-和β-巯基丙酰基丙氨酸以及α-和β-巯基丙酰基甘氨酸的愈创木酚酯，其化学式为 其中 R 是氢或甲基，Y 是氢或酰基（乙酰基、苯甲酰基或甲氧基羰基）。 含有这些愈创木酚酯的药物组合物具有粘液溶解活性。 制造这些愈创木酚酯的工艺包括以已知的本身方式制备含巯基的中间体，其中的巯基被三苯甲基或对甲氧基苄基保护，然后在酸性条件下去除保护基。
• Effect of heteroatoms in the side chains of disklike molecules on the formation of discotic liquid crystalline phases
  作者：David M. Collard、C. Peter Lillya

  DOI：10.1021/jo00021a020

  日期：1991.10

  Incorportion of oxygen and sulfur atoms into the side chains of discotic liquid crystals generally results in a depression of both the crystal to discotic and discotic to isotropic transition temperatures relative to the n-alkyl analogue. In contrast, replacement of the methylenes in side-chain positions 4 of 2,3,6,7,10,11-hexakis(alkanoyloxy)triphenylenes increases the clearing (M-I) temperature from 120 to 200-degrees-C. This effect is specific for sulfur substitution, to the triphenylene series, and to the 4-position. It is not expected, based on a simple model for discotic-phase formation.
• Synthesis and biological activity of ammonium alkylthiopropionates
  作者：Yu. B. Pisarskii、T. V. Nefedova、N. M. Boiko、L. T. Moskvitina、L. A. Mansurova、A. B. Skornyakova、T. Ya. Pushechkina、A. N. Vavilova、V. B. Kazimirovskaya、B. A. Trofimov

  DOI：10.1007/bf00768983

  日期：1991.10
• METHODS AND COMPOSITIONS FOR TARGETING GC1QR/P32
  申请人：Burnham Institute for Medical Research

  公开号：EP2043696A2

  公开（公告）日：2009-04-08