cis-2,3-dihydrospiro[2-benzoyl-3-phenyl-cyclopropane]-1,2'-indane-1',3'-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis-2,3-dihydrospiro[2-benzoyl-3-phenyl-cyclopropane]-1,2'-indane-1',3'-dione
• 英文别名: (2SR,3SR)-2-benzoyl-3-phenylspiro[cyclopropane-1,2'-indene]-1',3'-dione；(2R,3R)-2-benzoyl-3-phenylspiro[cyclopropane-1,2'-indene]-1',3'-dione
• 化学式: C₂₄H₁₆O₃
• 分子量: 352.389
• InChiKey: SVOUPMSMZUFSJA-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-2,3-dihydrospiro[2-benzoyl-3-phenyl-cyclopropane]-1,2'-indane-1',3'-dione 、 sodium methylate 生成 cis-1-Phenyl-2-benzoyl-3-phthaloyl-propen-(1)
  参考文献：
  名称：

  ZAVRAZHNOV V. I.; MOISEEVA L. V.; EROFEEVA M. R., EHLEKTRON. I XIMIYA V KARDIOL., (VORONEZH), 1978, HO 10, 93-96

  摘要：

  DOI：
• 作为产物：
  描述：

  2-bromo-2-[(1R,2S)-2-bromo-3-oxo-1,3-diphenylpropyl]indene-1,3-dione 、 碘化钾 生成 cis-2,3-dihydrospiro[2-benzoyl-3-phenyl-cyclopropane]-1,2'-indane-1',3'-dione
  参考文献：
  名称：

  ZAVRAZHNOV V. I.; MOISEEVA L. V.; EROFEEVA M. R., EHLEKTRON. I XIMIYA V KARDIOL., (VORONEZH), 1978, HO 10, 93-96

  摘要：

  DOI：

文献信息

• Highly diastereoselective spiro-cyclopropanation of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides
  作者：Jie Huang、Shaofa Sun、Ping Ma、Jian Wang、Kevin Lee、Yalan Xing、Yang Wu、Gangqiang Wang

  DOI：10.1039/d1nj02886c

  日期：——

  This efficient and simple protocol features simple operations, mild conditions and excellent functional group compatibility. A variety of structurally interesting spiro-cyclopropanes were prepared in excellent yields and diastereomeric ratios (up to 97% yield and 20 : 1 dr). Also, ring expansion of the cyclopropanation product to quickly deliver a complex indeno[1,2-c]pyridazine structure showcased

  2-亚芳基-1,3-茚二酮和二甲基锍叶立德的高度非对映选择性螺环丙烷化反应已通过碱诱导环化开发。这种高效简单的方案具有操作简单、条件温和、功能组兼容性好等特点。以优异的产率和非对映体比率（高达 97% 的产率和 20:1 dr）制备了各种结构有趣的螺环丙烷。此外，环丙烷化产物的扩环以快速提供复杂的茚并[1,2- c ]哒嗪结构展示了该方法的有趣应用。
• Triphenylarsine-Catalyzed Cyclopropanation: Highly Stereoselective Synthesis of <b> <i>Trans</i> </b>-2,3-Dihydro-Spiro[Cyclopropane-1,2′-Indan-1′,3′-dione] from Alkene and Phenacyl Bromide
  作者：Zhongjiao Ren、Weiguo Cao、Weiqi Tong、Jie Chen、Hongmei Deng、Danyi Wu

  DOI：10.1080/00397910802029406

  日期：2008.6.20

  The triphenylarsine-catalyzed approach for the highly stereoselective synthesis of trans-2,3-dihydro-spiro[cyclopropane-1,2'-indan-1',3'-dione] with alkenes and phenacyl bromide in organic solvent is described. The triphenylarsine-catalyzed cyclopropanation in water was investigated. The mixture of cis/trans isomers is provided with water as a solvent. The cis isomer is formed using water as a solvent. The reactivity of the reaction in water is higher than that in the organic solvent.
• BELYX S. I.; KUDRYAVTSEVA G. A.; LOJM N. M.; ZALUKAEV L. P.; PARNES Z. N.+, IZV. AN CCCP. CEP. XIM., 1978, HO 10, 2343-2347
  作者：BELYX S. I.、 KUDRYAVTSEVA G. A.、 LOJM N. M.、 ZALUKAEV L. P.、 PARNES Z. N.+

  DOI：——

  日期：——
• ZAVRAZHNOV V. I.; MOISEEVA L. V.; EROFEEVA M. R., EHLEKTRON. I XIMIYA V KARDIOL., (VORONEZH), 1978, HO 10, 93-96
  作者：ZAVRAZHNOV V. I.、 MOISEEVA L. V.、 EROFEEVA M. R.

  DOI：——

  日期：——