3-(4-Methoxy-3,5-dimethylpyridin-2-yl)propanal | 212779-06-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-Methoxy-3,5-dimethylpyridin-2-yl)propanal
• CAS: 212779-06-1
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: SIZBTTMMZCGEDW-UHFFFAOYSA-N

物化性质

• 沸点：
  294.423±35.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.040±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  L-半胱氨酸乙酯盐酸盐 、 3-(4-Methoxy-3,5-dimethylpyridin-2-yl)propanal 以 苯 为溶剂， 反应 6.0h， 以69%的产率得到ethyl (4R)-2-[2-(4-methoxy-3,5-dimethylpyridin-2-yl)ethyl]-1,3-thiazolidine-4-carboxylate
  参考文献：
  名称：

  Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric inhibitor

  摘要：

  A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/H+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00334-5
• 作为产物：
  描述：

  3-甲氧基-3,5-二甲基吡啶-2-甲醛 在 palladium on activated charcoal sodium hydroxide 、 氢气 作用下， 以 甲醇 为溶剂， 25.0 ℃ 、96.53 kPa 条件下， 反应 1.03h， 生成 3-(4-Methoxy-3,5-dimethylpyridin-2-yl)propanal
  参考文献：
  名称：

  Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric inhibitor

  摘要：

  A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/H+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00334-5

文献信息

• Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric inhibitor
  作者：Sung-Hwa Yoon、SeungKi Seo、YoungHee Lee、SungKwan Hwang、Dong Yeon Kim

  DOI：10.1016/s0960-894x(98)00334-5

  日期：1998.7

  A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/H+-ATPase. Compound 4d exhibited potent in vitro inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.