(4-((diethylamino)methyl)phenyl)methanol | 91271-57-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-((diethylamino)methyl)phenyl)methanol
• 英文别名: p-Diethylaminomethylbenzyl alcohol；4-diethylaminomethyl-benzyl alcohol；4-Diaethylaminomethyl-benzylalkohol；{4-[(diethylamino)methyl]phenyl}methanol；[4-(diethylaminomethyl)phenyl]methanol
• CAS: 91271-57-7
• 化学式: C₁₂H₁₉NO
• 分子量: 193.289
• InChiKey: BCTQOKMMSCGSIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-((diethylamino)methyl)phenyl)methanol 在 盐酸 、 乙醇 作用下， 生成 diethyl-(4-chloromethyl-benzyl)-amine; hydrochloride
  参考文献：
  名称：

  Determination of Macronutrients, by Chemical Analysis, of Home-Prepared Milk Feeding Bottles and their Contribution to the Energy and Protein Requirements of Infants from High and Low Socioeconomic Classes

  摘要：

  Objectives: To determine the macronutrients composition of home-prepared milk feeding bottles, by chemical analysis, and assess their contribution to the energy and protein requirements of children under two years of age from high (HSE) and low (LSE) socioeconomic classes.Methods: 72 samples were analyzed for energy density and protein, fat and carbohydrate content: 41 from the LSE group and 31 from the HSE group. The assessment of the percentages of the energy and protein requirements met by the consumption of the milk bottles was calculated as follows: the energy and protein per 100 mL obtained through chemical analysis were multiplied by the volume consumed at each feeding, then by the number of feedings per day, the results divided by the energy and protein requirements and multiplied by 100. Energy and protein requirements were those recommended by the FAO/WHO/UNU Committee and the Food and Nutrition Board. The children's weight-for-age index was assessed.Results: Unmodified cow's milk was largely consumed by both groups. The addition of sugar and other ingredients to the milk was significantly higher in the LSE group. Moisture, protein and fat content were lower in the LSE group. whereas carbohydrate and energy content were higher. The percentages of energy and protein requirements provided by feeding bottles were higher in the LSE group. Children in the LSE group had lower z-scores for weight-for-age.Conclusions: Differences in the preparation practices led to differences in the chemical results. The feeding bottles in the LSE group were high in energy, due to the addition of sugar and cereals to the milk in the bottle. The milk feeding bottles were an important weaning food providing more than 50% and 100% of the children's energy and protein requirements, respectively. The children's weight-for-age index was within the normal Lb-aits.

  DOI：

  10.1080/07315724.2002.10719222
• 作为产物：
  描述：

  diethyl-(4-bromomethyl-benzyl)-amine 在 potassium acetate 、 溶剂黄146 作用下， 生成 (4-((diethylamino)methyl)phenyl)methanol
  参考文献：
  名称：

  Determination of Macronutrients, by Chemical Analysis, of Home-Prepared Milk Feeding Bottles and their Contribution to the Energy and Protein Requirements of Infants from High and Low Socioeconomic Classes

  摘要：

  Objectives: To determine the macronutrients composition of home-prepared milk feeding bottles, by chemical analysis, and assess their contribution to the energy and protein requirements of children under two years of age from high (HSE) and low (LSE) socioeconomic classes.Methods: 72 samples were analyzed for energy density and protein, fat and carbohydrate content: 41 from the LSE group and 31 from the HSE group. The assessment of the percentages of the energy and protein requirements met by the consumption of the milk bottles was calculated as follows: the energy and protein per 100 mL obtained through chemical analysis were multiplied by the volume consumed at each feeding, then by the number of feedings per day, the results divided by the energy and protein requirements and multiplied by 100. Energy and protein requirements were those recommended by the FAO/WHO/UNU Committee and the Food and Nutrition Board. The children's weight-for-age index was assessed.Results: Unmodified cow's milk was largely consumed by both groups. The addition of sugar and other ingredients to the milk was significantly higher in the LSE group. Moisture, protein and fat content were lower in the LSE group. whereas carbohydrate and energy content were higher. The percentages of energy and protein requirements provided by feeding bottles were higher in the LSE group. Children in the LSE group had lower z-scores for weight-for-age.Conclusions: Differences in the preparation practices led to differences in the chemical results. The feeding bottles in the LSE group were high in energy, due to the addition of sugar and cereals to the milk in the bottle. The milk feeding bottles were an important weaning food providing more than 50% and 100% of the children's energy and protein requirements, respectively. The children's weight-for-age index was within the normal Lb-aits.

  DOI：

  10.1080/07315724.2002.10719222

文献信息

• Cyclovinylogues of some Antimuscarinic Drugs
  作者：Piero Valenti、Paola Montanari、Giuseppina Fabbri、Luca Giovannini、Aduo Giacomelli

  DOI：10.1002/ardp.19853180308

  日期：——

  Syntheses of some cyclovinylogues of antimuscarinic drugs, in which a benzene ring is interposed between the methylene groups of the basic chain, are reported. The pharmacological properties of the products were investigated.

  报道了一些抗毒蕈碱药物的环乙烯基化合物的合成，其中苯环插入在基本链的亚甲基之间。对产物的药理性质进行了研究。
• NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
  申请人：Mani Neelakandha S.

  公开号：US20120029191A1

  公开（公告）日：2012-02-02

  The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

  本发明涉及一种新型的环丙基酰胺衍生物制备方法，用于治疗由组胺受体介导的疾病和病症。
• Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains
  作者：Sandra Gemma、Gagan Kukreja、Caterina Fattorusso、Marco Persico、Maria P. Romano、Maria Altarelli、Luisa Savini、Giuseppe Campiani、Ernesto Fattorusso、Nicoletta Basilico、Donatella Taramelli、Vanessa Yardley、Stefania Butini

  DOI：10.1016/j.bmcl.2006.07.060

  日期：2006.10

  A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs. (c) 2006 Elsevier Ltd. All rights reserved.
• 3,4-Dihydro-1,3,5-triazin-2(1<i>H</i>)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease
  作者：Federica Prati、Angela De Simone、Andrea Armirotti、Maria Summa、Daniela Pizzirani、Rita Scarpelli、Sine Mandrup Bertozzi、Daniel I. Perez、Vincenza Andrisano、Ana Perez-Castillo、Barbara Monti、Francesca Massenzio、Letizia Polito、Marco Racchi、Piera Sabatino、Giovanni Bottegoni、Ana Martinez、Andrea Cavalli、Maria L. Bolognesi

  DOI：10.1021/acschemneuro.5b00121

  日期：2015.10.21

  One of the main obstacles toward the discovery of effective anti-Alzheimer drugs is the multifactorial nature of its etiopathology. Therefore, the use of multitarget-directed ligands has emerged as particularly suitable. Such ligands, able to modulate different neurodegenerative pathways, for example, amyloid and tau cascades, as well as cognitive and neurogenic functions, are fostered to come. In this respect, we report herein on the first class of BACE-1/GSK-3 beta dual inhibitors based on a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton, whose hit compound 1 showed interesting properties in a preliminary investigation. Notably, compound 2, endowed with well-balanced potencies against the two isolated enzymes (IC50 of 16 and 7 mu M against BACE-1 and GSK-3 beta, respectively), displayed effective neuroprotective and neurogenic activities and no neurotoxicity in cell-based assays. It also showed good brain permeability in a pharmacokinetic assessment in mice. Overall, triazinone derivatives, thanks to the simultaneous modulation of multiple points of the diseased network, might emerge as suitable candidates to be tested in in vivo Alzheimer's disease models.
• [EN] QUINOLIN-4-YLHYDRAZINE DERIVATIVES AS ANTIMALARIAL AGENT<br/>[FR] DÉRIVÉS DE QUINOLIN-4-YLHYDRAZINE EN TANT QU'AGENTS ANTIMALARIAUX
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2007104695A1

  公开（公告）日：2007-09-20

  [EN] Novel quinolyl and acridinylhydrazone compounds of formula (I), which present remarkable biological activity especially against the choloroquine-resistant Plasmodium falciparum strains, useful for the treatment and prevention of malaria infection are described herein.
  [FR] La présente invention concerne des quinolinyl- et des acridinyl-hydrazones de formule (I) dont l'activité biologique est remarquable, en particulier contre les souches de Plasmodium falciparum résistantes à la chloroquine, et qui peuvent être employées dans le traitement prophylactique et thérapeutique d'une infection de malaria.