ethyl 4-[(diethylamino)methyl]benzoate | 128982-36-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-[(diethylamino)methyl]benzoate
• 英文别名: 4-diethylaminomethyl-benzoic acid ethyl ester；4-Diaethylaminomethyl-benzoesaeure-aethylester；Ethyl 4-(diethylaminomethyl)benzoate
• CAS: 128982-36-5
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: ZGFXGJKXYRUVKG-UHFFFAOYSA-N

物化性质

• 沸点：
  311.4±25.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 4-[(diethylamino)methyl]benzoate 在 乙醇 、 sodium 作用下， 生成 (4-((diethylamino)methyl)phenyl)methanol
  参考文献：
  名称：

  Determination of Macronutrients, by Chemical Analysis, of Home-Prepared Milk Feeding Bottles and their Contribution to the Energy and Protein Requirements of Infants from High and Low Socioeconomic Classes

  摘要：

  Objectives: To determine the macronutrients composition of home-prepared milk feeding bottles, by chemical analysis, and assess their contribution to the energy and protein requirements of children under two years of age from high (HSE) and low (LSE) socioeconomic classes.Methods: 72 samples were analyzed for energy density and protein, fat and carbohydrate content: 41 from the LSE group and 31 from the HSE group. The assessment of the percentages of the energy and protein requirements met by the consumption of the milk bottles was calculated as follows: the energy and protein per 100 mL obtained through chemical analysis were multiplied by the volume consumed at each feeding, then by the number of feedings per day, the results divided by the energy and protein requirements and multiplied by 100. Energy and protein requirements were those recommended by the FAO/WHO/UNU Committee and the Food and Nutrition Board. The children's weight-for-age index was assessed.Results: Unmodified cow's milk was largely consumed by both groups. The addition of sugar and other ingredients to the milk was significantly higher in the LSE group. Moisture, protein and fat content were lower in the LSE group. whereas carbohydrate and energy content were higher. The percentages of energy and protein requirements provided by feeding bottles were higher in the LSE group. Children in the LSE group had lower z-scores for weight-for-age.Conclusions: Differences in the preparation practices led to differences in the chemical results. The feeding bottles in the LSE group were high in energy, due to the addition of sugar and cereals to the milk in the bottle. The milk feeding bottles were an important weaning food providing more than 50% and 100% of the children's energy and protein requirements, respectively. The children's weight-for-age index was within the normal Lb-aits.

  DOI：

  10.1080/07315724.2002.10719222
• 作为产物：
  描述：

  对氯甲基苯甲酸 在 盐酸 、 乙醇 作用下， 生成 ethyl 4-[(diethylamino)methyl]benzoate
  参考文献：
  名称：

  Einhorn; Papastavros, Justus Liebigs Annalen der Chemie, 1900, vol. 310, p. 205

  摘要：

  DOI：

文献信息

• An Expedient Three-Component Synthesis of Tertiary Benzylamines
  作者：Erwan Le Gall、Alexandre Decompte、Thierry Martens、Michel Troupel

  DOI：10.1055/s-0029-1217108

  日期：2010.1

  A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde is described. This procedure, which involves the in situ formation of arylzinc reagents, allows the straightforward synthesis of a range of functionalized tertiary benzylamines.

  描述了一种类似于曼尼希反应的锌介导的三组分反应，涉及芳香卤化物、胺和派拉甲醛。该过程通过原位生成芳基锌试剂，使得合成多种功能化的三级苄胺变得简便。
• US4910206A
  申请人：——

  公开号：US4910206A

  公开（公告）日：1990-03-20