((2R,3R,4S,5R,6S)-6-(((2R,3S,4R,5R,6R)-5-acetamido-6-(3-aminopropoxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl hydrogen sulfate | 788819-14-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((2R,3R,4S,5R,6S)-6-(((2R,3S,4R,5R,6R)-5-acetamido-6-(3-aminopropoxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl hydrogen sulfate
• CAS: 788819-14-7
• 化学式: C₁₇H₃₂N₂O₁₄S
• 分子量: 520.512
• InChiKey: JLXRDTOCXCONEW-FKUDBFNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.05
• 重原子数：
  34.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  256.79
• 氢给体数：
  8.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  ((2R,3R,4S,5R,6S)-6-(((2R,3S,4R,5R,6R)-5-acetamido-6-(3-aminopropoxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl hydrogen sulfate 、 乙酸酐 在 水 作用下， 以 异丙醇 为溶剂， 生成
  参考文献：
  名称：

  Identification of a new carbohydrate-binding site of influenza virus

  摘要：

  It has recently been shown that the influenza virus can specifically bind the residue of a nonsialylated sulfated oligosaccharide Gal(6SO(3)H)beta 1-4GlcNAc beta (6 ' SLacNAc). To identify by photoaffinity labeling the virion component that binds 6 ' SLacNAc, we synthesized a carbohydrate probe containing a I-125 labeled diazocyclopentadien-2-yl carbonyl group as an aglycone. According to the electrophoretic data, the labeled areas corresponded to a large hemagglutinin subunit, a nucleocapsid protein, and neuraminidase (NA). Probing in the presence of an excess of 6 ' SLacNAc beta-OCH2CH2NHAc glycoside resulted in redistribution of the labeling intensity, with the maximum inhibition being observed for NA. The data obtained indicate that NA is a viral 6 ' SLacNAc-binding protein.

  DOI：

  10.1134/s1068162008050154